The effect of feeding system in the expression of genes related with fat metabolism in semitendinous muscle in sheep
The effect of feeding system on the expression of LPL, ACACA, FASN, FABP4, DGAT1, SCD, CPT1B, PRKAA2, LEP, SREBP1, PPARG, PPARA and CEBPB genes in semitendinous muscle was studied. Forty-four single born male lambs of the Rasa Aragonesa breed, allocated to four different dietary treatments, were use...
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| Veröffentlicht in: | Meat science 2011-09, Vol.89 (1), p.91-97 |
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| creator | Dervishi, E. Serrano, C. Joy, M. Serrano, M. Rodellar, C. Calvo, J.H. |
| description | The effect of feeding system on the expression of
LPL, ACACA, FASN, FABP4, DGAT1, SCD, CPT1B, PRKAA2, LEP, SREBP1, PPARG, PPARA and
CEBPB genes in
semitendinous muscle was studied. Forty-four single born male lambs of the Rasa Aragonesa breed, allocated to four different dietary treatments, were used: grazing alfalfa, grazing alfalfa with supplement for lambs, indoor lambs with grazing ewes and drylot.
Significant differences were found in the expression of genes
LPL,
ACACA, FASN, FABP4,
CPT1B and
SCD. Genes related to adipogenesis (
LPL,
ACACA, FASN, FABP4, and
SCD) are up-regulated in the intensive groups. In grazing groups
CPT1B gene expression, related to β-oxidation process, is up-regulated
. The relative expression of
CPT1B was 1.54 fold higher in ALF
+
S, and 0.43 and 0.37 fold lower in IND- GRE and IND, respectively.
The results support the hypothesis that changes in fatty acid profile due to feeding system implicate changes in the mRNA expression level of genes related with fat metabolism. Feeding strategy is an important tool to manipulate intramuscular fatty acid profile in meat through altering gene expression of enzymes related with fat metabolism. |
| doi_str_mv | 10.1016/j.meatsci.2011.04.003 |
| format | Article |
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LPL, ACACA, FASN, FABP4, DGAT1, SCD, CPT1B, PRKAA2, LEP, SREBP1, PPARG, PPARA and
CEBPB genes in
semitendinous muscle was studied. Forty-four single born male lambs of the Rasa Aragonesa breed, allocated to four different dietary treatments, were used: grazing alfalfa, grazing alfalfa with supplement for lambs, indoor lambs with grazing ewes and drylot.
Significant differences were found in the expression of genes
LPL,
ACACA, FASN, FABP4,
CPT1B and
SCD. Genes related to adipogenesis (
LPL,
ACACA, FASN, FABP4, and
SCD) are up-regulated in the intensive groups. In grazing groups
CPT1B gene expression, related to β-oxidation process, is up-regulated
. The relative expression of
CPT1B was 1.54 fold higher in ALF
+
S, and 0.43 and 0.37 fold lower in IND- GRE and IND, respectively.
The results support the hypothesis that changes in fatty acid profile due to feeding system implicate changes in the mRNA expression level of genes related with fat metabolism. Feeding strategy is an important tool to manipulate intramuscular fatty acid profile in meat through altering gene expression of enzymes related with fat metabolism.</description><identifier>ISSN: 0309-1740</identifier><identifier>EISSN: 1873-4138</identifier><identifier>DOI: 10.1016/j.meatsci.2011.04.003</identifier><identifier>PMID: 21543161</identifier><identifier>CODEN: MESCDN</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Acetyl-CoA Carboxylase - genetics ; Acetyl-CoA Carboxylase - metabolism ; Adipogenesis - genetics ; alfalfa ; Animal Feed - analysis ; Animals ; Biological and medical sciences ; Carnitine O-Palmitoyltransferase - genetics ; Carnitine O-Palmitoyltransferase - metabolism ; Diacylglycerol O-Acyltransferase - genetics ; Diacylglycerol O-Acyltransferase - metabolism ; enzymes ; ewes ; Fat metabolism ; fatty acid composition ; Fatty Acids - analysis ; Fatty Acids - chemistry ; Feeding system ; Female ; Food industries ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression Regulation ; genes ; grazing ; lambs ; lipid metabolism ; Lipid Metabolism - genetics ; Male ; Meat ; Meat and meat product industries ; Medicago sativa - metabolism ; messenger RNA ; Muscle, Skeletal - metabolism ; PPAR alpha - genetics ; PPAR alpha - metabolism ; Rasa Aragonesa ; semitendinosus muscle ; Sheep ; Sheep, Domestic - genetics ; Sheep, Domestic - metabolism ; Up-Regulation</subject><ispartof>Meat science, 2011-09, Vol.89 (1), p.91-97</ispartof><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-6b52a0b70e8742b52021ed9d41512ba175858a6603c69c678386e90dbad9326c3</citedby><cites>FETCH-LOGICAL-c418t-6b52a0b70e8742b52021ed9d41512ba175858a6603c69c678386e90dbad9326c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0309174011001318$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24260481$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21543161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dervishi, E.</creatorcontrib><creatorcontrib>Serrano, C.</creatorcontrib><creatorcontrib>Joy, M.</creatorcontrib><creatorcontrib>Serrano, M.</creatorcontrib><creatorcontrib>Rodellar, C.</creatorcontrib><creatorcontrib>Calvo, J.H.</creatorcontrib><title>The effect of feeding system in the expression of genes related with fat metabolism in semitendinous muscle in sheep</title><title>Meat science</title><addtitle>Meat Sci</addtitle><description>The effect of feeding system on the expression of
LPL, ACACA, FASN, FABP4, DGAT1, SCD, CPT1B, PRKAA2, LEP, SREBP1, PPARG, PPARA and
CEBPB genes in
semitendinous muscle was studied. Forty-four single born male lambs of the Rasa Aragonesa breed, allocated to four different dietary treatments, were used: grazing alfalfa, grazing alfalfa with supplement for lambs, indoor lambs with grazing ewes and drylot.
Significant differences were found in the expression of genes
LPL,
ACACA, FASN, FABP4,
CPT1B and
SCD. Genes related to adipogenesis (
LPL,
ACACA, FASN, FABP4, and
SCD) are up-regulated in the intensive groups. In grazing groups
CPT1B gene expression, related to β-oxidation process, is up-regulated
. The relative expression of
CPT1B was 1.54 fold higher in ALF
+
S, and 0.43 and 0.37 fold lower in IND- GRE and IND, respectively.
The results support the hypothesis that changes in fatty acid profile due to feeding system implicate changes in the mRNA expression level of genes related with fat metabolism. Feeding strategy is an important tool to manipulate intramuscular fatty acid profile in meat through altering gene expression of enzymes related with fat metabolism.</description><subject>Acetyl-CoA Carboxylase - genetics</subject><subject>Acetyl-CoA Carboxylase - metabolism</subject><subject>Adipogenesis - genetics</subject><subject>alfalfa</subject><subject>Animal Feed - analysis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carnitine O-Palmitoyltransferase - genetics</subject><subject>Carnitine O-Palmitoyltransferase - metabolism</subject><subject>Diacylglycerol O-Acyltransferase - genetics</subject><subject>Diacylglycerol O-Acyltransferase - metabolism</subject><subject>enzymes</subject><subject>ewes</subject><subject>Fat metabolism</subject><subject>fatty acid composition</subject><subject>Fatty Acids - analysis</subject><subject>Fatty Acids - chemistry</subject><subject>Feeding system</subject><subject>Female</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>genes</subject><subject>grazing</subject><subject>lambs</subject><subject>lipid metabolism</subject><subject>Lipid Metabolism - genetics</subject><subject>Male</subject><subject>Meat</subject><subject>Meat and meat product industries</subject><subject>Medicago sativa - metabolism</subject><subject>messenger RNA</subject><subject>Muscle, Skeletal - metabolism</subject><subject>PPAR alpha - genetics</subject><subject>PPAR alpha - metabolism</subject><subject>Rasa Aragonesa</subject><subject>semitendinosus muscle</subject><subject>Sheep</subject><subject>Sheep, Domestic - genetics</subject><subject>Sheep, Domestic - metabolism</subject><subject>Up-Regulation</subject><issn>0309-1740</issn><issn>1873-4138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhJwC-IE4J49hxnBNCFV9SJQ60Z8txJrte5WPxeAv99zjdBY6cLHued-b1O4y9FFAKEPrdvpzQJfKhrECIElQJIB-xjTCNLJSQ5jHbgIS2EI2CC_aMaA8AQlbmKbuoRK2k0GLD0s0OOQ4D-sSXgQ-IfZi3nO4p4cTDzNNa_3WISBSWeWW2OCPxiKNL2POfIe344BKfMLluGQM9yAinkHDOzZYj8elIfsSH9x3i4Tl7MriR8MX5vGS3nz7eXH0prr99_nr14brwSphU6K6uHHQNoGlUlS9QCezbXolaVJ0TTW1q47QG6XXrdWOk0dhC37m-lZX28pK9PfU9xOXHESnZKZDHcXQzZlvWaCObRuomk_WJ9HEhijjYQwyTi_dWgF3ztnt7ztuueVtQNuedda_OE47dhP1f1Z-AM_DmDDjybhyim32gf5yqNCizcq9P3OAW67YxM7ff8ySVd2bq_OFMvD8RmBO7CxhtNoOzzwuLeXu2X8J_zP4GSeGqOg</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Dervishi, E.</creator><creator>Serrano, C.</creator><creator>Joy, M.</creator><creator>Serrano, M.</creator><creator>Rodellar, C.</creator><creator>Calvo, J.H.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>The effect of feeding system in the expression of genes related with fat metabolism in semitendinous muscle in sheep</title><author>Dervishi, E. ; Serrano, C. ; Joy, M. ; Serrano, M. ; Rodellar, C. ; Calvo, J.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-6b52a0b70e8742b52021ed9d41512ba175858a6603c69c678386e90dbad9326c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetyl-CoA Carboxylase - genetics</topic><topic>Acetyl-CoA Carboxylase - metabolism</topic><topic>Adipogenesis - genetics</topic><topic>alfalfa</topic><topic>Animal Feed - analysis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carnitine O-Palmitoyltransferase - genetics</topic><topic>Carnitine O-Palmitoyltransferase - metabolism</topic><topic>Diacylglycerol O-Acyltransferase - genetics</topic><topic>Diacylglycerol O-Acyltransferase - metabolism</topic><topic>enzymes</topic><topic>ewes</topic><topic>Fat metabolism</topic><topic>fatty acid composition</topic><topic>Fatty Acids - analysis</topic><topic>Fatty Acids - chemistry</topic><topic>Feeding system</topic><topic>Female</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>genes</topic><topic>grazing</topic><topic>lambs</topic><topic>lipid metabolism</topic><topic>Lipid Metabolism - genetics</topic><topic>Male</topic><topic>Meat</topic><topic>Meat and meat product industries</topic><topic>Medicago sativa - metabolism</topic><topic>messenger RNA</topic><topic>Muscle, Skeletal - metabolism</topic><topic>PPAR alpha - genetics</topic><topic>PPAR alpha - metabolism</topic><topic>Rasa Aragonesa</topic><topic>semitendinosus muscle</topic><topic>Sheep</topic><topic>Sheep, Domestic - genetics</topic><topic>Sheep, Domestic - metabolism</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dervishi, E.</creatorcontrib><creatorcontrib>Serrano, C.</creatorcontrib><creatorcontrib>Joy, M.</creatorcontrib><creatorcontrib>Serrano, M.</creatorcontrib><creatorcontrib>Rodellar, C.</creatorcontrib><creatorcontrib>Calvo, J.H.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Meat science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dervishi, E.</au><au>Serrano, C.</au><au>Joy, M.</au><au>Serrano, M.</au><au>Rodellar, C.</au><au>Calvo, J.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of feeding system in the expression of genes related with fat metabolism in semitendinous muscle in sheep</atitle><jtitle>Meat science</jtitle><addtitle>Meat Sci</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>89</volume><issue>1</issue><spage>91</spage><epage>97</epage><pages>91-97</pages><issn>0309-1740</issn><eissn>1873-4138</eissn><coden>MESCDN</coden><abstract>The effect of feeding system on the expression of
LPL, ACACA, FASN, FABP4, DGAT1, SCD, CPT1B, PRKAA2, LEP, SREBP1, PPARG, PPARA and
CEBPB genes in
semitendinous muscle was studied. Forty-four single born male lambs of the Rasa Aragonesa breed, allocated to four different dietary treatments, were used: grazing alfalfa, grazing alfalfa with supplement for lambs, indoor lambs with grazing ewes and drylot.
Significant differences were found in the expression of genes
LPL,
ACACA, FASN, FABP4,
CPT1B and
SCD. Genes related to adipogenesis (
LPL,
ACACA, FASN, FABP4, and
SCD) are up-regulated in the intensive groups. In grazing groups
CPT1B gene expression, related to β-oxidation process, is up-regulated
. The relative expression of
CPT1B was 1.54 fold higher in ALF
+
S, and 0.43 and 0.37 fold lower in IND- GRE and IND, respectively.
The results support the hypothesis that changes in fatty acid profile due to feeding system implicate changes in the mRNA expression level of genes related with fat metabolism. Feeding strategy is an important tool to manipulate intramuscular fatty acid profile in meat through altering gene expression of enzymes related with fat metabolism.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21543161</pmid><doi>10.1016/j.meatsci.2011.04.003</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Meat science, 2011-09, Vol.89 (1), p.91-97 |
| issn | 0309-1740 1873-4138 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetyl-CoA Carboxylase - genetics Acetyl-CoA Carboxylase - metabolism Adipogenesis - genetics alfalfa Animal Feed - analysis Animals Biological and medical sciences Carnitine O-Palmitoyltransferase - genetics Carnitine O-Palmitoyltransferase - metabolism Diacylglycerol O-Acyltransferase - genetics Diacylglycerol O-Acyltransferase - metabolism enzymes ewes Fat metabolism fatty acid composition Fatty Acids - analysis Fatty Acids - chemistry Feeding system Female Food industries Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation genes grazing lambs lipid metabolism Lipid Metabolism - genetics Male Meat Meat and meat product industries Medicago sativa - metabolism messenger RNA Muscle, Skeletal - metabolism PPAR alpha - genetics PPAR alpha - metabolism Rasa Aragonesa semitendinosus muscle Sheep Sheep, Domestic - genetics Sheep, Domestic - metabolism Up-Regulation |
| title | The effect of feeding system in the expression of genes related with fat metabolism in semitendinous muscle in sheep |
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