Differential metabolism of androst-5-ene-3β,17β-diol between rats, canines, monkeys and humans

► The majority of rat 5-AED metabolites contained three or more oxygen substituents. ► Human hepatocytes primarily metabolized 5-AED into DHEA. ► Very little 5-AED and DHEA were hydroxylated by human hepatocytes. ► Humans do not significantly metabolize DHEA into anti-inflammatory triols. The potent...

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Veröffentlicht in:	Steroids 2011-06, Vol.76 (7), p.669-674
Hauptverfasser:	Ahlem, Clarence N., White, Steven K., Page, Theodore M., Frincke, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-AED Androstene Androstenediol - metabolism Animals Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Biological and medical sciences Dehydroepiandrosterone - metabolism Dehydroepiandrosterone - pharmacology DHEA Differential metabolism Dogs Fundamental and applied biological sciences. Psychology Haplorhini Hepatocytes - drug effects Hepatocytes - metabolism Human Humans Rats Rodent Species Specificity Vertebrates: endocrinology
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