Oleate Blocks Palmitate-Induced Abnormal Lipid Distribution, Endoplasmic Reticulum Expansion and Stress, and Insulin Resistance in Skeletal Muscle

Oleate competes with palmitate in its negative regulation of insulin sensitivity via governing palmitate-derived lipid composition and localization and relieving palmitate-induced endoplasmic reticulum (ER) expansion and ER stress. Pathological elevation of plasma fatty acids reduces insulin sensiti...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2011-06, Vol.152 (6), p.2206-2218
Hauptverfasser:	Peng, Gong, Li, Linghai, Liu, Yanbo, Pu, Jing, Zhang, Shuyan, Yu, Jinhai, Zhao, Junjie, Liu, Pingsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid resistance AKT protein Animals Biological and medical sciences Butyric acid Cell differentiation Cell Line Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diglycerides Down-Regulation Endoplasmic reticulum Endoplasmic Reticulum - metabolism Fatty acids Fundamental and applied biological sciences. Psychology Humans Insulin Insulin - metabolism Insulin Resistance Kinases Lipid composition Lipid Metabolism Lipids Localization Male Mice Molecular modelling Muscle, Skeletal - metabolism Muscles Musculoskeletal system Oleic acid Oleic Acid - metabolism Oxidative Stress Palmitates - metabolism Palmitic acid Phospholipids Phosphorylation Protein kinase R Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Sensitivity Signal Transduction Skeletal muscle Striated muscle. Tendons Triglycerides Vertebrates: endocrinology Vertebrates: osteoarticular system, musculoskeletal system
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