A new technique for spectrophotometric determination of Pseudoephedrine and Guaifenesin in syrup and synthetic mixture
The accuracy in predicting different chemometric methods was compared when applied on ordinary UV spectra and first order derivative spectra. Principal component regression (PCR) and partial least squares with one dependent variable (PLS1) and two dependent variables (PLS2) were applied on spectral...
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| Veröffentlicht in: | Drug testing and analysis 2011-05, Vol.3 (5), p.319-324 |
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| creator | Riahi, Siavash Hadiloo, Farshad Milani, Seyed Mohammad R. Davarkhah, Nazila Ganjali, Mohammad R. Norouzi, Parviz Seyfi, Payam |
| description | The accuracy in predicting different chemometric methods was compared when applied on ordinary UV spectra and first order derivative spectra. Principal component regression (PCR) and partial least squares with one dependent variable (PLS1) and two dependent variables (PLS2) were applied on spectral data of pharmaceutical formula containing Pseudoephedrine (PDP) and Guaifenesin (GFN). The ability to derivitize in resolved overlapping spectra chloropheniramine maleate was evaluated when multivariate methods are adopted for analysis of two component mixtures without using any chemical pretreatment. The chemometrics models were tested on an external validation dataset and finally applied to the analysis of pharmaceuticals. Significant advantages were found in analysis of the real samples when the calibration models from derivative spectra were used. It should also be mentioned that the proposed method is a simple and rapid way requiring no preliminary separation steps and can be used easily for the analysis of these compounds, especially in quality control laboratories. Copyright © 2011 John Wiley & Sons, Ltd.
The accuracy in predicting different chemometric methods were compared when applied on ordinary UV spectra and first order derivative spectra. Principal component regression (PCR) and partial least squares with one dependent variable (PLS‐1) and two dependent variables (PLS2) were applied on spectral data of pharmaceutical formula containing Pseudoephedrine (PDP) and Guaifenesin (GFN). The ability to derivitize in resolved overlapping spectra chloropheniramine maleate was evaluated when the multivariate methods are adopted for analysis of two component mixtures without using any chemical pre‐treatment. |
| doi_str_mv | 10.1002/dta.235 |
| format | Article |
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The accuracy in predicting different chemometric methods were compared when applied on ordinary UV spectra and first order derivative spectra. Principal component regression (PCR) and partial least squares with one dependent variable (PLS‐1) and two dependent variables (PLS2) were applied on spectral data of pharmaceutical formula containing Pseudoephedrine (PDP) and Guaifenesin (GFN). The ability to derivitize in resolved overlapping spectra chloropheniramine maleate was evaluated when the multivariate methods are adopted for analysis of two component mixtures without using any chemical pre‐treatment.</description><identifier>ISSN: 1942-7603</identifier><identifier>EISSN: 1942-7611</identifier><identifier>DOI: 10.1002/dta.235</identifier><identifier>PMID: 21598410</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Bronchodilator Agents - administration & dosage ; Bronchodilator Agents - analysis ; Bronchodilator Agents - chemistry ; chemometrics ; derivative ; Drug Combinations ; Drug Stability ; Expectorants - administration & dosage ; Expectorants - analysis ; Expectorants - chemistry ; Guaifenesin - administration & dosage ; Guaifenesin - analysis ; Guaifenesin - chemistry ; Least-Squares Analysis ; partial least squares (PLS) ; Principal Component Analysis ; principal component regression (PCR) ; Pseudoephedrine - administration & dosage ; Pseudoephedrine - analysis ; Pseudoephedrine - chemistry ; Pseudoephedrine and Guaifenesin ; spectrophotometer ; Spectrophotometry, Ultraviolet - methods</subject><ispartof>Drug testing and analysis, 2011-05, Vol.3 (5), p.319-324</ispartof><rights>Copyright © 2011 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3545-4ecbc91b22b592bd868238dd6a0516cd18b270752fa3d945fe9cce08be7cddba3</citedby><cites>FETCH-LOGICAL-c3545-4ecbc91b22b592bd868238dd6a0516cd18b270752fa3d945fe9cce08be7cddba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdta.235$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdta.235$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21598410$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riahi, Siavash</creatorcontrib><creatorcontrib>Hadiloo, Farshad</creatorcontrib><creatorcontrib>Milani, Seyed Mohammad R.</creatorcontrib><creatorcontrib>Davarkhah, Nazila</creatorcontrib><creatorcontrib>Ganjali, Mohammad R.</creatorcontrib><creatorcontrib>Norouzi, Parviz</creatorcontrib><creatorcontrib>Seyfi, Payam</creatorcontrib><title>A new technique for spectrophotometric determination of Pseudoephedrine and Guaifenesin in syrup and synthetic mixture</title><title>Drug testing and analysis</title><addtitle>Drug Test Analysis</addtitle><description>The accuracy in predicting different chemometric methods was compared when applied on ordinary UV spectra and first order derivative spectra. Principal component regression (PCR) and partial least squares with one dependent variable (PLS1) and two dependent variables (PLS2) were applied on spectral data of pharmaceutical formula containing Pseudoephedrine (PDP) and Guaifenesin (GFN). The ability to derivitize in resolved overlapping spectra chloropheniramine maleate was evaluated when multivariate methods are adopted for analysis of two component mixtures without using any chemical pretreatment. The chemometrics models were tested on an external validation dataset and finally applied to the analysis of pharmaceuticals. Significant advantages were found in analysis of the real samples when the calibration models from derivative spectra were used. It should also be mentioned that the proposed method is a simple and rapid way requiring no preliminary separation steps and can be used easily for the analysis of these compounds, especially in quality control laboratories. Copyright © 2011 John Wiley & Sons, Ltd.
The accuracy in predicting different chemometric methods were compared when applied on ordinary UV spectra and first order derivative spectra. Principal component regression (PCR) and partial least squares with one dependent variable (PLS‐1) and two dependent variables (PLS2) were applied on spectral data of pharmaceutical formula containing Pseudoephedrine (PDP) and Guaifenesin (GFN). The ability to derivitize in resolved overlapping spectra chloropheniramine maleate was evaluated when the multivariate methods are adopted for analysis of two component mixtures without using any chemical pre‐treatment.</description><subject>Bronchodilator Agents - administration & dosage</subject><subject>Bronchodilator Agents - analysis</subject><subject>Bronchodilator Agents - chemistry</subject><subject>chemometrics</subject><subject>derivative</subject><subject>Drug Combinations</subject><subject>Drug Stability</subject><subject>Expectorants - administration & dosage</subject><subject>Expectorants - analysis</subject><subject>Expectorants - chemistry</subject><subject>Guaifenesin - administration & dosage</subject><subject>Guaifenesin - analysis</subject><subject>Guaifenesin - chemistry</subject><subject>Least-Squares Analysis</subject><subject>partial least squares (PLS)</subject><subject>Principal Component Analysis</subject><subject>principal component regression (PCR)</subject><subject>Pseudoephedrine - administration & dosage</subject><subject>Pseudoephedrine - analysis</subject><subject>Pseudoephedrine - chemistry</subject><subject>Pseudoephedrine and Guaifenesin</subject><subject>spectrophotometer</subject><subject>Spectrophotometry, Ultraviolet - methods</subject><issn>1942-7603</issn><issn>1942-7611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kFtLHDEUgINYvFX8B5I3H8rYXCZzeVy0rrbSC2zxMWSSM2x0JxmTjLr_3ti126dC4ATOxwfnQ-iEknNKCPtskjpnXOygA9qWrKgrSne3f8L30WGM94RUZYb20D6jom1KSg7Q0ww7eMYJ9NLZxwlw7wOOI-gU_Lj0yQ-QgtXYQIIwWKeS9Q77Hv-MMBkP4xJMsA6wcgbPJ2V7cBCtw_nFdZjGP4u4dmkJKXsG-5KmAB_Rh16tIhy_zyP0--rL4uK6uP0xv7mY3Raai1IUJehOt7RjrBMt60xTNYw3xlSKCFppQ5uO1aQWrFfctKXoodUaSNNBrY3pFD9CZxvvGHy-LiY52KhhtVIO_BRlFhJOWir-kTr4GAP0cgx2UGEtKZFvjWVuLHO-TJ6-O6duALPl_kbNwKcN8GxXsP6fR14uZhtdsaFtTPCypVV4kFXNayHvvs_lYtE2X39dE_mNvwLCkZdb</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Riahi, Siavash</creator><creator>Hadiloo, Farshad</creator><creator>Milani, Seyed Mohammad R.</creator><creator>Davarkhah, Nazila</creator><creator>Ganjali, Mohammad R.</creator><creator>Norouzi, Parviz</creator><creator>Seyfi, Payam</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201105</creationdate><title>A new technique for spectrophotometric determination of Pseudoephedrine and Guaifenesin in syrup and synthetic mixture</title><author>Riahi, Siavash ; Hadiloo, Farshad ; Milani, Seyed Mohammad R. ; Davarkhah, Nazila ; Ganjali, Mohammad R. ; Norouzi, Parviz ; Seyfi, Payam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3545-4ecbc91b22b592bd868238dd6a0516cd18b270752fa3d945fe9cce08be7cddba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Bronchodilator Agents - administration & dosage</topic><topic>Bronchodilator Agents - analysis</topic><topic>Bronchodilator Agents - chemistry</topic><topic>chemometrics</topic><topic>derivative</topic><topic>Drug Combinations</topic><topic>Drug Stability</topic><topic>Expectorants - administration & dosage</topic><topic>Expectorants - analysis</topic><topic>Expectorants - chemistry</topic><topic>Guaifenesin - administration & dosage</topic><topic>Guaifenesin - analysis</topic><topic>Guaifenesin - chemistry</topic><topic>Least-Squares Analysis</topic><topic>partial least squares (PLS)</topic><topic>Principal Component Analysis</topic><topic>principal component regression (PCR)</topic><topic>Pseudoephedrine - administration & dosage</topic><topic>Pseudoephedrine - analysis</topic><topic>Pseudoephedrine - chemistry</topic><topic>Pseudoephedrine and Guaifenesin</topic><topic>spectrophotometer</topic><topic>Spectrophotometry, Ultraviolet - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riahi, Siavash</creatorcontrib><creatorcontrib>Hadiloo, Farshad</creatorcontrib><creatorcontrib>Milani, Seyed Mohammad R.</creatorcontrib><creatorcontrib>Davarkhah, Nazila</creatorcontrib><creatorcontrib>Ganjali, Mohammad R.</creatorcontrib><creatorcontrib>Norouzi, Parviz</creatorcontrib><creatorcontrib>Seyfi, Payam</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug testing and analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riahi, Siavash</au><au>Hadiloo, Farshad</au><au>Milani, Seyed Mohammad R.</au><au>Davarkhah, Nazila</au><au>Ganjali, Mohammad R.</au><au>Norouzi, Parviz</au><au>Seyfi, Payam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new technique for spectrophotometric determination of Pseudoephedrine and Guaifenesin in syrup and synthetic mixture</atitle><jtitle>Drug testing and analysis</jtitle><addtitle>Drug Test Analysis</addtitle><date>2011-05</date><risdate>2011</risdate><volume>3</volume><issue>5</issue><spage>319</spage><epage>324</epage><pages>319-324</pages><issn>1942-7603</issn><eissn>1942-7611</eissn><abstract>The accuracy in predicting different chemometric methods was compared when applied on ordinary UV spectra and first order derivative spectra. Principal component regression (PCR) and partial least squares with one dependent variable (PLS1) and two dependent variables (PLS2) were applied on spectral data of pharmaceutical formula containing Pseudoephedrine (PDP) and Guaifenesin (GFN). The ability to derivitize in resolved overlapping spectra chloropheniramine maleate was evaluated when multivariate methods are adopted for analysis of two component mixtures without using any chemical pretreatment. The chemometrics models were tested on an external validation dataset and finally applied to the analysis of pharmaceuticals. Significant advantages were found in analysis of the real samples when the calibration models from derivative spectra were used. It should also be mentioned that the proposed method is a simple and rapid way requiring no preliminary separation steps and can be used easily for the analysis of these compounds, especially in quality control laboratories. Copyright © 2011 John Wiley & Sons, Ltd.
The accuracy in predicting different chemometric methods were compared when applied on ordinary UV spectra and first order derivative spectra. Principal component regression (PCR) and partial least squares with one dependent variable (PLS‐1) and two dependent variables (PLS2) were applied on spectral data of pharmaceutical formula containing Pseudoephedrine (PDP) and Guaifenesin (GFN). The ability to derivitize in resolved overlapping spectra chloropheniramine maleate was evaluated when the multivariate methods are adopted for analysis of two component mixtures without using any chemical pre‐treatment.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>21598410</pmid><doi>10.1002/dta.235</doi><tpages>6</tpages></addata></record> |
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| ispartof | Drug testing and analysis, 2011-05, Vol.3 (5), p.319-324 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Bronchodilator Agents - administration & dosage Bronchodilator Agents - analysis Bronchodilator Agents - chemistry chemometrics derivative Drug Combinations Drug Stability Expectorants - administration & dosage Expectorants - analysis Expectorants - chemistry Guaifenesin - administration & dosage Guaifenesin - analysis Guaifenesin - chemistry Least-Squares Analysis partial least squares (PLS) Principal Component Analysis principal component regression (PCR) Pseudoephedrine - administration & dosage Pseudoephedrine - analysis Pseudoephedrine - chemistry Pseudoephedrine and Guaifenesin spectrophotometer Spectrophotometry, Ultraviolet - methods |
| title | A new technique for spectrophotometric determination of Pseudoephedrine and Guaifenesin in syrup and synthetic mixture |
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