Endothelial origin of mesenchymal stem cells
Mesenchymal stem/stromal cells (MSCs) are fibroblastoid cells capable of long-term expansion and skeletogenic differentiation. While MSCs are known to originate from neural crest and mesoderm, immediate mesodermal precursors that give rise to MSCs have not been characterized. Recently, using human e...
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| Veröffentlicht in: | Cell cycle (Georgetown, Tex.) Tex.), 2011-05, Vol.10 (9), p.1370-1373 |
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| creator | Slukvin, Igor I. Vodyanik, Maxim |
| description | Mesenchymal stem/stromal cells (MSCs) are fibroblastoid cells capable of long-term expansion and skeletogenic differentiation. While MSCs are known to originate from neural crest and mesoderm, immediate mesodermal precursors that give rise to MSCs have not been characterized. Recently, using human embryonic stem cells (hESCs), we demonstrated that mesodermal MSCs arise from APLNR+ precursors with angiogenic potential, mesenchymoangioblasts, which can be identified by FGF2-dependent colony-forming assay in serum-free semisolid medium. In this overview we provide additional insights on cellular pathways leading to MSC establishment from mesoderm, with special emphasis on endothelial-mesenchymal transition as a critical step in MSC formation. In addition, we highlight an essential role of FGF2 in induction of angiogenic cells with potential to transform into MSCs (mesenchymoangioblasts) or hematopoietic cells (hemangioblasts) from mesoderm, and discuss correlations of our in vitro findings with the course of angioblast development during embryogenesis. |
| doi_str_mv | 10.4161/cc.10.9.15345 |
| format | Article |
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While MSCs are known to originate from neural crest and mesoderm, immediate mesodermal precursors that give rise to MSCs have not been characterized. Recently, using human embryonic stem cells (hESCs), we demonstrated that mesodermal MSCs arise from APLNR+ precursors with angiogenic potential, mesenchymoangioblasts, which can be identified by FGF2-dependent colony-forming assay in serum-free semisolid medium. In this overview we provide additional insights on cellular pathways leading to MSC establishment from mesoderm, with special emphasis on endothelial-mesenchymal transition as a critical step in MSC formation. In addition, we highlight an essential role of FGF2 in induction of angiogenic cells with potential to transform into MSCs (mesenchymoangioblasts) or hematopoietic cells (hemangioblasts) from mesoderm, and discuss correlations of our in vitro findings with the course of angioblast development during embryogenesis.</description><identifier>ISSN: 1538-4101</identifier><identifier>EISSN: 1551-4005</identifier><identifier>DOI: 10.4161/cc.10.9.15345</identifier><identifier>PMID: 21444996</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Binding ; Biology ; Bioscience ; Calcium ; Cancer ; Cell ; Cell Differentiation - physiology ; Cell Lineage - physiology ; Cycle ; Endothelial Cells - cytology ; Endothelial Cells - physiology ; Epithelial-Mesenchymal Transition - physiology ; Extra View ; Humans ; Landes ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - physiology ; Organogenesis ; Proteins</subject><ispartof>Cell cycle (Georgetown, Tex.), 2011-05, Vol.10 (9), p.1370-1373</ispartof><rights>Copyright © 2011 Landes Bioscience 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-12be292e63b8fec92d1ac423a4354186c6015ab4ed2981ebb999d112990932833</citedby><cites>FETCH-LOGICAL-c584t-12be292e63b8fec92d1ac423a4354186c6015ab4ed2981ebb999d112990932833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117041/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117041/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21444996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slukvin, Igor I.</creatorcontrib><creatorcontrib>Vodyanik, Maxim</creatorcontrib><title>Endothelial origin of mesenchymal stem cells</title><title>Cell cycle (Georgetown, Tex.)</title><addtitle>Cell Cycle</addtitle><description>Mesenchymal stem/stromal cells (MSCs) are fibroblastoid cells capable of long-term expansion and skeletogenic differentiation. 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In addition, we highlight an essential role of FGF2 in induction of angiogenic cells with potential to transform into MSCs (mesenchymoangioblasts) or hematopoietic cells (hemangioblasts) from mesoderm, and discuss correlations of our in vitro findings with the course of angioblast development during embryogenesis.</description><subject>Binding</subject><subject>Biology</subject><subject>Bioscience</subject><subject>Calcium</subject><subject>Cancer</subject><subject>Cell</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Lineage - physiology</subject><subject>Cycle</subject><subject>Endothelial Cells - cytology</subject><subject>Endothelial Cells - physiology</subject><subject>Epithelial-Mesenchymal Transition - physiology</subject><subject>Extra View</subject><subject>Humans</subject><subject>Landes</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - physiology</subject><subject>Organogenesis</subject><subject>Proteins</subject><issn>1538-4101</issn><issn>1551-4005</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1rGzEQxUVJaT7aY6_Ft1yyrkbSbqRLIZh8FAw5JD0LrXbWVqKVXGmd4P--cpyaFgI56aH5zZuZR8hXoFMBDXy3dlqkmkLNRf2BHEFdQyUorQ-2mstKAIVDcpzzA6VMniv4RA4ZCCGUao7I2WXo4rhE74yfxOQWLkxiPxkwY7DLzVB-84jDxKL3-TP52Buf8cvre0J-XV3ez26q-e31z9nFvLK1FGMFrEWmGDa8lT1axTowVjBuBK8FyMY2FGrTCuyYkoBtq5TqAJhSVHEmOT8hP3a-q3U7YGcxjMl4vUpuMGmjo3H6_0pwS72IT5oDnFMBxeD01SDF32vMox5c3p5gAsZ11rKRlDWKiUJWO9KmmHPCfj8FqN4GrK3dSqVfAi78t39X29N_Ey0A3QFlVoe5dTFbV7LEPVoMTRqd9bj3hHda7vz68cmF2exlk1XXlx6563Ghj2kwzzH5To9m42PqkwnW5ZLGmyf8AcRnrOw</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Slukvin, Igor I.</creator><creator>Vodyanik, Maxim</creator><general>Taylor & Francis</general><general>Landes Bioscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110501</creationdate><title>Endothelial origin of mesenchymal stem cells</title><author>Slukvin, Igor I. ; Vodyanik, Maxim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-12be292e63b8fec92d1ac423a4354186c6015ab4ed2981ebb999d112990932833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Binding</topic><topic>Biology</topic><topic>Bioscience</topic><topic>Calcium</topic><topic>Cancer</topic><topic>Cell</topic><topic>Cell Differentiation - physiology</topic><topic>Cell Lineage - physiology</topic><topic>Cycle</topic><topic>Endothelial Cells - cytology</topic><topic>Endothelial Cells - physiology</topic><topic>Epithelial-Mesenchymal Transition - physiology</topic><topic>Extra View</topic><topic>Humans</topic><topic>Landes</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Mesenchymal Stromal Cells - physiology</topic><topic>Organogenesis</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slukvin, Igor I.</creatorcontrib><creatorcontrib>Vodyanik, Maxim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell cycle (Georgetown, Tex.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slukvin, Igor I.</au><au>Vodyanik, Maxim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial origin of mesenchymal stem cells</atitle><jtitle>Cell cycle (Georgetown, Tex.)</jtitle><addtitle>Cell Cycle</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>10</volume><issue>9</issue><spage>1370</spage><epage>1373</epage><pages>1370-1373</pages><issn>1538-4101</issn><eissn>1551-4005</eissn><abstract>Mesenchymal stem/stromal cells (MSCs) are fibroblastoid cells capable of long-term expansion and skeletogenic differentiation. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Binding Biology Bioscience Calcium Cancer Cell Cell Differentiation - physiology Cell Lineage - physiology Cycle Endothelial Cells - cytology Endothelial Cells - physiology Epithelial-Mesenchymal Transition - physiology Extra View Humans Landes Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - physiology Organogenesis Proteins |
| title | Endothelial origin of mesenchymal stem cells |
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