Understanding the radical mechanism of lipoxygenases using 31P NMR spin trapping

In this paper, we use our quantitative 31P NMR spin trapping methods, already developed for simple oxygen- and carbon-centered radicals, to understand the radical intermediates generated by enzymatic systems and more specifically lipoxygenases. Our methodology rests on the fact that free radicals re...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2011-05, Vol.19 (9), p.3022-3028
Hauptverfasser:	Zoia, Luca, Perazzini, Raffaella, Crestini, Claudia, Argyropoulos, Dimitris S.
Format:	Artikel
Sprache:	eng
Schlagworte:	31P NMR Analytical, structural and metabolic biochemistry Biological and medical sciences Cyclic N-Oxides - chemistry Enzymes and enzyme inhibitors free radicals Free Radicals - chemistry Fundamental and applied biological sciences. Psychology Glycine max - enzymology linoleic acid Linoleic Acid - metabolism Lipoxygenase - chemistry Lipoxygenase - metabolism Lipoxygenases Magnetic Resonance Spectroscopy nuclear magnetic resonance spectroscopy Organophosphonates - chemistry oxidation Oxidoreductases phosphorus Phosphorus Isotopes - chemistry Radicals soybeans Spin Trapping
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