Dietary l-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle
Obesity is a major health crisis worldwide and new treatments are needed to fight this epidemic. Using the swine model, we recently reported that dietary l-arginine (Arg) supplementation promotes muscle gain and reduces body-fat accretion. The present study tested the hypothesis that Arg regulates e...
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| Veröffentlicht in: | The Journal of nutritional biochemistry 2011-05, Vol.22 (5), p.441-445 |
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| creator | Tan, Bie Yin, Yulong Liu, Zhiqiang Tang, Wenjie Xu, Haijun Kong, Xiangfeng Li, Xinguo Yao, Kang Gu, Wanting Smith, Stephen B Wu, Guoyao |
| description | Obesity is a major health crisis worldwide and new treatments are needed to fight this epidemic. Using the swine model, we recently reported that dietary l-arginine (Arg) supplementation promotes muscle gain and reduces body-fat accretion. The present study tested the hypothesis that Arg regulates expression of key genes involved in lipid metabolism in skeletal muscle and white adipose tissue. Sixteen 110-day-old barrows were fed for 60 days a corn- and soybean-meal-based diet supplemented with 1.0% Arg or 2.05% l-alanine (isonitrogenous control). Blood samples, longissimus dorsi muscle and overlying subcutaneous adipose tissue were obtained from 170-day-old pigs for biochemical studies. Serum concentrations of leptin, alanine and glutamine were lower, but those for Arg and proline were higher in Arg-supplemented pigs than in control pigs. The percentage of oleic acid was higher but that of stearic acid and linoleic acid was lower in muscle of Arg-supplemented pigs, compared with control pigs. Dietary Arg supplementation increased mRNA levels for fatty acid synthase in muscle, while decreasing those for lipoprotein lipase, glucose transporter-4, and acetyl-coenzyme A carboxylase-α in adipose tissue. Additionally, mRNA levels for hormone sensitive lipase were higher in adipose tissue of Arg-supplemented pigs compared with control pigs. These results indicate that Arg differentially regulates expression of fat-metabolic genes in skeletal muscle and white adipose tissue, therefore favoring lipogenesis in muscle but lipolysis in adipose tissue. Our novel findings provide a biochemical basis for explaining the beneficial effect of Arg in improving the metabolic profile in mammals (including obese humans). |
| doi_str_mv | 10.1016/j.jnutbio.2010.03.012 |
| format | Article |
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Using the swine model, we recently reported that dietary l-arginine (Arg) supplementation promotes muscle gain and reduces body-fat accretion. The present study tested the hypothesis that Arg regulates expression of key genes involved in lipid metabolism in skeletal muscle and white adipose tissue. Sixteen 110-day-old barrows were fed for 60 days a corn- and soybean-meal-based diet supplemented with 1.0% Arg or 2.05% l-alanine (isonitrogenous control). Blood samples, longissimus dorsi muscle and overlying subcutaneous adipose tissue were obtained from 170-day-old pigs for biochemical studies. Serum concentrations of leptin, alanine and glutamine were lower, but those for Arg and proline were higher in Arg-supplemented pigs than in control pigs. The percentage of oleic acid was higher but that of stearic acid and linoleic acid was lower in muscle of Arg-supplemented pigs, compared with control pigs. Dietary Arg supplementation increased mRNA levels for fatty acid synthase in muscle, while decreasing those for lipoprotein lipase, glucose transporter-4, and acetyl-coenzyme A carboxylase-α in adipose tissue. Additionally, mRNA levels for hormone sensitive lipase were higher in adipose tissue of Arg-supplemented pigs compared with control pigs. These results indicate that Arg differentially regulates expression of fat-metabolic genes in skeletal muscle and white adipose tissue, therefore favoring lipogenesis in muscle but lipolysis in adipose tissue. Our novel findings provide a biochemical basis for explaining the beneficial effect of Arg in improving the metabolic profile in mammals (including obese humans).</description><identifier>ISSN: 0955-2863</identifier><identifier>EISSN: 1873-4847</identifier><identifier>DOI: 10.1016/j.jnutbio.2010.03.012</identifier><identifier>PMID: 20619625</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acetyl-CoA Carboxylase - analysis ; Adipose tissue ; Adipose Tissue, White - drug effects ; Adipose Tissue, White - metabolism ; alanine ; Alanine - blood ; Animals ; Arginine ; Arginine - administration & dosage ; Arginine - metabolism ; barrows ; Biological and medical sciences ; blood ; Chemical Phenomena ; diet ; Dietary Supplements ; Fat metabolism ; fatty-acid synthase ; Feeding. Feeding behavior ; fighting (behavior) ; Fundamental and applied biological sciences. Psychology ; Gene expression ; genes ; Glucose Transporter Type 4 - analysis ; glucose transporters ; glutamine ; Glutamine - blood ; humans ; leptin ; Leptin - blood ; linoleic acid ; Linoleic Acid - analysis ; Lipid Metabolism ; Lipogenesis - drug effects ; Lipolysis ; lipoprotein lipase ; Lipoprotein Lipase - analysis ; longissimus muscle ; Male ; messenger RNA ; Muscle ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - metabolism ; obesity ; Obesity - metabolism ; oleic acid ; Pig ; proline ; RNA, Messenger - analysis ; skeletal muscle ; stearic acid ; Stearic Acids - analysis ; Swine ; triacylglycerol lipase ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; white adipose tissue</subject><ispartof>The Journal of nutritional biochemistry, 2011-05, Vol.22 (5), p.441-445</ispartof><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-d568532cdf3cf296d72f91924e5d685c7ffedada410cd4ef917f6e13280ce5ea3</citedby><cites>FETCH-LOGICAL-c474t-d568532cdf3cf296d72f91924e5d685c7ffedada410cd4ef917f6e13280ce5ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0955286310000859$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24134648$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20619625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Bie</creatorcontrib><creatorcontrib>Yin, Yulong</creatorcontrib><creatorcontrib>Liu, Zhiqiang</creatorcontrib><creatorcontrib>Tang, Wenjie</creatorcontrib><creatorcontrib>Xu, Haijun</creatorcontrib><creatorcontrib>Kong, Xiangfeng</creatorcontrib><creatorcontrib>Li, Xinguo</creatorcontrib><creatorcontrib>Yao, Kang</creatorcontrib><creatorcontrib>Gu, Wanting</creatorcontrib><creatorcontrib>Smith, Stephen B</creatorcontrib><creatorcontrib>Wu, Guoyao</creatorcontrib><title>Dietary l-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle</title><title>The Journal of nutritional biochemistry</title><addtitle>J Nutr Biochem</addtitle><description>Obesity is a major health crisis worldwide and new treatments are needed to fight this epidemic. Using the swine model, we recently reported that dietary l-arginine (Arg) supplementation promotes muscle gain and reduces body-fat accretion. The present study tested the hypothesis that Arg regulates expression of key genes involved in lipid metabolism in skeletal muscle and white adipose tissue. Sixteen 110-day-old barrows were fed for 60 days a corn- and soybean-meal-based diet supplemented with 1.0% Arg or 2.05% l-alanine (isonitrogenous control). Blood samples, longissimus dorsi muscle and overlying subcutaneous adipose tissue were obtained from 170-day-old pigs for biochemical studies. Serum concentrations of leptin, alanine and glutamine were lower, but those for Arg and proline were higher in Arg-supplemented pigs than in control pigs. The percentage of oleic acid was higher but that of stearic acid and linoleic acid was lower in muscle of Arg-supplemented pigs, compared with control pigs. Dietary Arg supplementation increased mRNA levels for fatty acid synthase in muscle, while decreasing those for lipoprotein lipase, glucose transporter-4, and acetyl-coenzyme A carboxylase-α in adipose tissue. Additionally, mRNA levels for hormone sensitive lipase were higher in adipose tissue of Arg-supplemented pigs compared with control pigs. These results indicate that Arg differentially regulates expression of fat-metabolic genes in skeletal muscle and white adipose tissue, therefore favoring lipogenesis in muscle but lipolysis in adipose tissue. Our novel findings provide a biochemical basis for explaining the beneficial effect of Arg in improving the metabolic profile in mammals (including obese humans).</description><subject>Acetyl-CoA Carboxylase - analysis</subject><subject>Adipose tissue</subject><subject>Adipose Tissue, White - drug effects</subject><subject>Adipose Tissue, White - metabolism</subject><subject>alanine</subject><subject>Alanine - blood</subject><subject>Animals</subject><subject>Arginine</subject><subject>Arginine - administration & dosage</subject><subject>Arginine - metabolism</subject><subject>barrows</subject><subject>Biological and medical sciences</subject><subject>blood</subject><subject>Chemical Phenomena</subject><subject>diet</subject><subject>Dietary Supplements</subject><subject>Fat metabolism</subject><subject>fatty-acid synthase</subject><subject>Feeding. Feeding behavior</subject><subject>fighting (behavior)</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>genes</subject><subject>Glucose Transporter Type 4 - analysis</subject><subject>glucose transporters</subject><subject>glutamine</subject><subject>Glutamine - blood</subject><subject>humans</subject><subject>leptin</subject><subject>Leptin - blood</subject><subject>linoleic acid</subject><subject>Linoleic Acid - analysis</subject><subject>Lipid Metabolism</subject><subject>Lipogenesis - drug effects</subject><subject>Lipolysis</subject><subject>lipoprotein lipase</subject><subject>Lipoprotein Lipase - analysis</subject><subject>longissimus muscle</subject><subject>Male</subject><subject>messenger RNA</subject><subject>Muscle</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - metabolism</subject><subject>obesity</subject><subject>Obesity - metabolism</subject><subject>oleic acid</subject><subject>Pig</subject><subject>proline</subject><subject>RNA, Messenger - analysis</subject><subject>skeletal muscle</subject><subject>stearic acid</subject><subject>Stearic Acids - analysis</subject><subject>Swine</subject><subject>triacylglycerol lipase</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>white adipose tissue</subject><issn>0955-2863</issn><issn>1873-4847</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcuO1DAQRSMEYpqBTwC8QazS-BUnWSE0PKWRWMCsLbddblXj2MFOEPMR_DNudQM7YGWV69wq-96meczollGmXhy2h7guO0xbTusdFVvK-J1mw4ZetHKQ_d1mQ8eua_mgxEXzoJQDpZTLTt1vLjhVbFS82zQ_XiMsJt-S0Jq8x4gRSFnnOcAEcTELpkgceg-5lmhCuCUZ9mswCxQC3-cMpRyZ5EnAGV071XG7FNCSPcTKYCRzyvY41zicUwGyYClrLaMj5QuEKghkWosN8LC5500o8Oh8XjY3b998vnrfXn989-Hq1XVrZS-X1nVq6AS3zgvr-ahcz_3IRi6hc7Vj-_peZ5yRjFonofZ6r4AJPlALHRhx2Tw_zZ1z-rpCWfSExUIIJkJaix5U38uRcf4fJFfVfzVWsjuRNqdSMng9Z5yqtZpRfYxMH_Q5Mn2MTFOha2RV9-S8Yd1N4H6rfmVUgWdnwBRrgs8mWix_OMmEVHKo3NMT503SZp8rc_OpbpI1dyEY_zvBFGNH4uWJgOr-N4Ssi0WIFhxmsIt2Cf_xnZ_U5c3Z</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Tan, Bie</creator><creator>Yin, Yulong</creator><creator>Liu, Zhiqiang</creator><creator>Tang, Wenjie</creator><creator>Xu, Haijun</creator><creator>Kong, Xiangfeng</creator><creator>Li, Xinguo</creator><creator>Yao, Kang</creator><creator>Gu, Wanting</creator><creator>Smith, Stephen B</creator><creator>Wu, Guoyao</creator><general>Elsevier Inc</general><general>New York, NY: Elsevier Science</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20110501</creationdate><title>Dietary l-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle</title><author>Tan, Bie ; Yin, Yulong ; Liu, Zhiqiang ; Tang, Wenjie ; Xu, Haijun ; Kong, Xiangfeng ; Li, Xinguo ; Yao, Kang ; Gu, Wanting ; Smith, Stephen B ; Wu, Guoyao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-d568532cdf3cf296d72f91924e5d685c7ffedada410cd4ef917f6e13280ce5ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetyl-CoA Carboxylase - analysis</topic><topic>Adipose tissue</topic><topic>Adipose Tissue, White - drug effects</topic><topic>Adipose Tissue, White - metabolism</topic><topic>alanine</topic><topic>Alanine - blood</topic><topic>Animals</topic><topic>Arginine</topic><topic>Arginine - administration & dosage</topic><topic>Arginine - metabolism</topic><topic>barrows</topic><topic>Biological and medical sciences</topic><topic>blood</topic><topic>Chemical Phenomena</topic><topic>diet</topic><topic>Dietary Supplements</topic><topic>Fat metabolism</topic><topic>fatty-acid synthase</topic><topic>Feeding. Feeding behavior</topic><topic>fighting (behavior)</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>genes</topic><topic>Glucose Transporter Type 4 - analysis</topic><topic>glucose transporters</topic><topic>glutamine</topic><topic>Glutamine - blood</topic><topic>humans</topic><topic>leptin</topic><topic>Leptin - blood</topic><topic>linoleic acid</topic><topic>Linoleic Acid - analysis</topic><topic>Lipid Metabolism</topic><topic>Lipogenesis - drug effects</topic><topic>Lipolysis</topic><topic>lipoprotein lipase</topic><topic>Lipoprotein Lipase - analysis</topic><topic>longissimus muscle</topic><topic>Male</topic><topic>messenger RNA</topic><topic>Muscle</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - metabolism</topic><topic>obesity</topic><topic>Obesity - metabolism</topic><topic>oleic acid</topic><topic>Pig</topic><topic>proline</topic><topic>RNA, Messenger - analysis</topic><topic>skeletal muscle</topic><topic>stearic acid</topic><topic>Stearic Acids - analysis</topic><topic>Swine</topic><topic>triacylglycerol lipase</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>white adipose tissue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Bie</creatorcontrib><creatorcontrib>Yin, Yulong</creatorcontrib><creatorcontrib>Liu, Zhiqiang</creatorcontrib><creatorcontrib>Tang, Wenjie</creatorcontrib><creatorcontrib>Xu, Haijun</creatorcontrib><creatorcontrib>Kong, Xiangfeng</creatorcontrib><creatorcontrib>Li, Xinguo</creatorcontrib><creatorcontrib>Yao, Kang</creatorcontrib><creatorcontrib>Gu, Wanting</creatorcontrib><creatorcontrib>Smith, Stephen B</creatorcontrib><creatorcontrib>Wu, Guoyao</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>The Journal of nutritional biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Bie</au><au>Yin, Yulong</au><au>Liu, Zhiqiang</au><au>Tang, Wenjie</au><au>Xu, Haijun</au><au>Kong, Xiangfeng</au><au>Li, Xinguo</au><au>Yao, Kang</au><au>Gu, Wanting</au><au>Smith, Stephen B</au><au>Wu, Guoyao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary l-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle</atitle><jtitle>The Journal of nutritional biochemistry</jtitle><addtitle>J Nutr Biochem</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>22</volume><issue>5</issue><spage>441</spage><epage>445</epage><pages>441-445</pages><issn>0955-2863</issn><eissn>1873-4847</eissn><abstract>Obesity is a major health crisis worldwide and new treatments are needed to fight this epidemic. Using the swine model, we recently reported that dietary l-arginine (Arg) supplementation promotes muscle gain and reduces body-fat accretion. The present study tested the hypothesis that Arg regulates expression of key genes involved in lipid metabolism in skeletal muscle and white adipose tissue. Sixteen 110-day-old barrows were fed for 60 days a corn- and soybean-meal-based diet supplemented with 1.0% Arg or 2.05% l-alanine (isonitrogenous control). Blood samples, longissimus dorsi muscle and overlying subcutaneous adipose tissue were obtained from 170-day-old pigs for biochemical studies. Serum concentrations of leptin, alanine and glutamine were lower, but those for Arg and proline were higher in Arg-supplemented pigs than in control pigs. The percentage of oleic acid was higher but that of stearic acid and linoleic acid was lower in muscle of Arg-supplemented pigs, compared with control pigs. Dietary Arg supplementation increased mRNA levels for fatty acid synthase in muscle, while decreasing those for lipoprotein lipase, glucose transporter-4, and acetyl-coenzyme A carboxylase-α in adipose tissue. Additionally, mRNA levels for hormone sensitive lipase were higher in adipose tissue of Arg-supplemented pigs compared with control pigs. These results indicate that Arg differentially regulates expression of fat-metabolic genes in skeletal muscle and white adipose tissue, therefore favoring lipogenesis in muscle but lipolysis in adipose tissue. Our novel findings provide a biochemical basis for explaining the beneficial effect of Arg in improving the metabolic profile in mammals (including obese humans).</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20619625</pmid><doi>10.1016/j.jnutbio.2010.03.012</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of nutritional biochemistry, 2011-05, Vol.22 (5), p.441-445 |
| issn | 0955-2863 1873-4847 |
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| subjects | Acetyl-CoA Carboxylase - analysis Adipose tissue Adipose Tissue, White - drug effects Adipose Tissue, White - metabolism alanine Alanine - blood Animals Arginine Arginine - administration & dosage Arginine - metabolism barrows Biological and medical sciences blood Chemical Phenomena diet Dietary Supplements Fat metabolism fatty-acid synthase Feeding. Feeding behavior fighting (behavior) Fundamental and applied biological sciences. Psychology Gene expression genes Glucose Transporter Type 4 - analysis glucose transporters glutamine Glutamine - blood humans leptin Leptin - blood linoleic acid Linoleic Acid - analysis Lipid Metabolism Lipogenesis - drug effects Lipolysis lipoprotein lipase Lipoprotein Lipase - analysis longissimus muscle Male messenger RNA Muscle Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism obesity Obesity - metabolism oleic acid Pig proline RNA, Messenger - analysis skeletal muscle stearic acid Stearic Acids - analysis Swine triacylglycerol lipase Vertebrates: anatomy and physiology, studies on body, several organs or systems white adipose tissue |
| title | Dietary l-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle |
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