Protective effect of l -kynurenine and probenecid on 6-hydroxydopamine-induced striatal toxicity in rats: Implications of modulating kynurenate as a protective strategy

Abstract The neuroactive metabolite at the kynunerine pathway, kynurenic acid (KYNA), is a well-known competitive antagonist at the co-agonist glycine site of the n -methyl- d -aspartate receptor (NMDAr), and also decreases the extracellular levels of glutamate by blocking α7-nicotinic acetylcholine...

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Veröffentlicht in:	Neurotoxicology and teratology 2011-03, Vol.33 (2), p.303-312
Hauptverfasser:	Silva-Adaya, Daniela, Pérez-De La Cruz, Verónica, Villeda-Hernández, Juana, Carrillo-Mora, Paul, González-Herrera, Irma Gabriela, García, Esperanza, Colín-Barenque, Laura, Pedraza-Chaverrí, José, Santamaría, Abel
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Acetylcholine receptors Animals Behavior, Animal - drug effects Biological and medical sciences Brain Corpus Striatum - drug effects Corpus Striatum - metabolism Disease Models, Animal Dopamine Dose-Response Relationship, Drug Drug Therapy, Combination Emergency Extracellular levels Glial fibrillary acidic protein Gliosis Glutamatergic transmission Glutamic acid receptors Glycine Immunohistochemistry Kynurenic acid Kynurenic Acid - metabolism Kynurenine Kynurenine - administration & dosage Kynurenine - therapeutic use Kynurenine pathway Male Medical Education Medical sciences Metabolites Movement disorders N-Methyl-D-aspartic acid receptors Neostriatum Neurodegeneration Neurodegenerative diseases Neuroprotection Neuroprotective Agents - administration & dosage Neuroprotective Agents - therapeutic use Neurotoxicity Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - prevention & control Organic acids Oxidopamine - toxicity Parkinson's disease Parkinson's disease model Probenecid Probenecid - administration & dosage Probenecid - therapeutic use Proteins Rats Rats, Wistar rodents Toxicity Toxicology Toxins
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