Anaplastic sarcoma of the kidney with chromosomal abnormality: first report on cytogenetic findings
Summary We report a case of anaplastic sarcoma of the kidney (ASK) with cytogenetic findings. A 12-year-old Japanese girl presented with buttock pain and urinary incontinence. Radiological investigations revealed a right renal tumor with multiple distant metastases and multicystic thyroid tumor. She...
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| Veröffentlicht in: | Human pathology 2010-10, Vol.41 (10), p.1495-1499 |
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| creator | Gomi, Kiyoshi, MD, PhD Hamanoue, Satoshi, MD, PhD Tanaka, Mio, MD, PhD Matsumoto, Masae, MD, PhD Kitagawa, Norihiko, MD, PhD Niwa, Tetsu, MD, PhD Aida, Noriko, MD, PhD Kigasawa, Hisato, MD, PhD Tanaka, Yukichi, MD, PhD |
| description | Summary We report a case of anaplastic sarcoma of the kidney (ASK) with cytogenetic findings. A 12-year-old Japanese girl presented with buttock pain and urinary incontinence. Radiological investigations revealed a right renal tumor with multiple distant metastases and multicystic thyroid tumor. She underwent radical right nephrectomy and subsequently received chemotherapy and radiation therapy. Histologically, the renal tumor demonstrated admixture of various types of mesenchymal elements: cellular spindle cells with anaplastic features, cartilage, and rhabdomyoblastic cells consistent with ASK. Chromosomal analysis revealed the karyotype of the tumor cells to be 46, XX, +8, –10, der (18) t (10; 18) (q21; p11.2). The thyroid tumor was removed later and diagnosed as adenomatous goiter. To our knowledge, this is the first case of ASK with chromosomal abnormality and may provide new insight into the molecular biologic basis of this rare renal tumor. |
| doi_str_mv | 10.1016/j.humpath.2010.03.008 |
| format | Article |
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A 12-year-old Japanese girl presented with buttock pain and urinary incontinence. Radiological investigations revealed a right renal tumor with multiple distant metastases and multicystic thyroid tumor. She underwent radical right nephrectomy and subsequently received chemotherapy and radiation therapy. Histologically, the renal tumor demonstrated admixture of various types of mesenchymal elements: cellular spindle cells with anaplastic features, cartilage, and rhabdomyoblastic cells consistent with ASK. Chromosomal analysis revealed the karyotype of the tumor cells to be 46, XX, +8, –10, der (18) t (10; 18) (q21; p11.2). The thyroid tumor was removed later and diagnosed as adenomatous goiter. To our knowledge, this is the first case of ASK with chromosomal abnormality and may provide new insight into the molecular biologic basis of this rare renal tumor.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2010.03.008</identifier><identifier>PMID: 20656319</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Anaplastic sarcoma of kidney ; Biological and medical sciences ; Cancer ; Cartilage ; Chemotherapy ; Child ; Children ; Chromosomal abnormality ; Chromosome Aberrations ; Female ; Goiter - genetics ; Goiter - pathology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Kidney Neoplasms - genetics ; Kidney Neoplasms - pathology ; Kidneys ; Life sciences ; Medical sciences ; Neoplasm Metastasis ; Neoplasms, Multiple Primary - genetics ; Neoplasms, Multiple Primary - pathology ; Nephrology. Urinary tract diseases ; Pathogenesis ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Polymerase chain reaction ; Renal tumor ; Sarcoma - genetics ; Sarcoma - secondary ; Studies ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - pathology ; Tumors ; Tumors of the urinary system</subject><ispartof>Human pathology, 2010-10, Vol.41 (10), p.1495-1499</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-eb2afe8399a81c3a6d0a9256fd6fdf361face7cf5ac7547e8dc7854eb38f4a1b3</citedby><cites>FETCH-LOGICAL-c509t-eb2afe8399a81c3a6d0a9256fd6fdf361face7cf5ac7547e8dc7854eb38f4a1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humpath.2010.03.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23312168$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20656319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gomi, Kiyoshi, MD, PhD</creatorcontrib><creatorcontrib>Hamanoue, Satoshi, MD, PhD</creatorcontrib><creatorcontrib>Tanaka, Mio, MD, PhD</creatorcontrib><creatorcontrib>Matsumoto, Masae, MD, PhD</creatorcontrib><creatorcontrib>Kitagawa, Norihiko, MD, PhD</creatorcontrib><creatorcontrib>Niwa, Tetsu, MD, PhD</creatorcontrib><creatorcontrib>Aida, Noriko, MD, PhD</creatorcontrib><creatorcontrib>Kigasawa, Hisato, MD, PhD</creatorcontrib><creatorcontrib>Tanaka, Yukichi, MD, PhD</creatorcontrib><title>Anaplastic sarcoma of the kidney with chromosomal abnormality: first report on cytogenetic findings</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary We report a case of anaplastic sarcoma of the kidney (ASK) with cytogenetic findings. A 12-year-old Japanese girl presented with buttock pain and urinary incontinence. Radiological investigations revealed a right renal tumor with multiple distant metastases and multicystic thyroid tumor. She underwent radical right nephrectomy and subsequently received chemotherapy and radiation therapy. Histologically, the renal tumor demonstrated admixture of various types of mesenchymal elements: cellular spindle cells with anaplastic features, cartilage, and rhabdomyoblastic cells consistent with ASK. Chromosomal analysis revealed the karyotype of the tumor cells to be 46, XX, +8, –10, der (18) t (10; 18) (q21; p11.2). The thyroid tumor was removed later and diagnosed as adenomatous goiter. To our knowledge, this is the first case of ASK with chromosomal abnormality and may provide new insight into the molecular biologic basis of this rare renal tumor.</description><subject>Anaplastic sarcoma of kidney</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cartilage</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Children</subject><subject>Chromosomal abnormality</subject><subject>Chromosome Aberrations</subject><subject>Female</subject><subject>Goiter - genetics</subject><subject>Goiter - pathology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidneys</subject><subject>Life sciences</subject><subject>Medical sciences</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasms, Multiple Primary - genetics</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Pathogenesis</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Polymerase chain reaction</subject><subject>Renal tumor</subject><subject>Sarcoma - genetics</subject><subject>Sarcoma - secondary</subject><subject>Studies</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2L1TAQhoMo7nH1JygBEa96TJqkH16sLItfsOCFeh3SdLLN2TapSar035tyji7szUIgIXnmnZm8g9BLSvaU0OrdYT8s06zSsC9JviNsT0jzCO2oYGXRsLZ8jHaE8KpoaF2foWcxHgihVHDxFJ2VpBIVo-0O6Uun5lHFZDWOKmg_KewNTgPgW9s7WPEfmwash-AnH_PriFXnfMgHm9b32NgQEw4w-5Cwd1ivyd-Ag03PWNdbdxOfoydGjRFenPZz9PPTxx9XX4rrb5-_Xl1eF1qQNhXQlcpALr1VDdVMVT1RbSkq0-dlWEWN0lBrI5SuBa-h6XXdCA4dawxXtGPn6O1Rdw7-1wIxyclGDeOoHPglyqaqa54j2YNkLQQnouZtJl_fIw9-CS63ISlhvGkJJzRT4kjp4GMMYOQc7KTCmiG52SUP8mSX3OyShMlsV457dVJfugn6_1H__MnAmxOgolajCcppG-84xmhJq03ow5GD_L-_LQQZtQWnobcBdJK9tw-WcnFPQY_W2Zz0FlaId13LWEoiv2-ztY0WJXmsGOPsL51lzDI</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Gomi, Kiyoshi, MD, PhD</creator><creator>Hamanoue, Satoshi, MD, PhD</creator><creator>Tanaka, Mio, MD, PhD</creator><creator>Matsumoto, Masae, MD, PhD</creator><creator>Kitagawa, Norihiko, MD, PhD</creator><creator>Niwa, Tetsu, MD, PhD</creator><creator>Aida, Noriko, MD, PhD</creator><creator>Kigasawa, Hisato, MD, PhD</creator><creator>Tanaka, Yukichi, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20101001</creationdate><title>Anaplastic sarcoma of the kidney with chromosomal abnormality: first report on cytogenetic findings</title><author>Gomi, Kiyoshi, MD, PhD ; Hamanoue, Satoshi, MD, PhD ; Tanaka, Mio, MD, PhD ; Matsumoto, Masae, MD, PhD ; Kitagawa, Norihiko, MD, PhD ; Niwa, Tetsu, MD, PhD ; Aida, Noriko, MD, PhD ; Kigasawa, Hisato, MD, PhD ; Tanaka, Yukichi, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-eb2afe8399a81c3a6d0a9256fd6fdf361face7cf5ac7547e8dc7854eb38f4a1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Anaplastic sarcoma of kidney</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Cartilage</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Children</topic><topic>Chromosomal abnormality</topic><topic>Chromosome Aberrations</topic><topic>Female</topic><topic>Goiter - genetics</topic><topic>Goiter - pathology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidneys</topic><topic>Life sciences</topic><topic>Medical sciences</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasms, Multiple Primary - genetics</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Pathogenesis</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Polymerase chain reaction</topic><topic>Renal tumor</topic><topic>Sarcoma - genetics</topic><topic>Sarcoma - secondary</topic><topic>Studies</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomi, Kiyoshi, MD, PhD</creatorcontrib><creatorcontrib>Hamanoue, Satoshi, MD, PhD</creatorcontrib><creatorcontrib>Tanaka, Mio, MD, PhD</creatorcontrib><creatorcontrib>Matsumoto, Masae, MD, PhD</creatorcontrib><creatorcontrib>Kitagawa, Norihiko, MD, PhD</creatorcontrib><creatorcontrib>Niwa, Tetsu, MD, PhD</creatorcontrib><creatorcontrib>Aida, Noriko, MD, PhD</creatorcontrib><creatorcontrib>Kigasawa, Hisato, MD, PhD</creatorcontrib><creatorcontrib>Tanaka, Yukichi, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomi, Kiyoshi, MD, PhD</au><au>Hamanoue, Satoshi, MD, PhD</au><au>Tanaka, Mio, MD, PhD</au><au>Matsumoto, Masae, MD, PhD</au><au>Kitagawa, Norihiko, MD, PhD</au><au>Niwa, Tetsu, MD, PhD</au><au>Aida, Noriko, MD, PhD</au><au>Kigasawa, Hisato, MD, PhD</au><au>Tanaka, Yukichi, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anaplastic sarcoma of the kidney with chromosomal abnormality: first report on cytogenetic findings</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>41</volume><issue>10</issue><spage>1495</spage><epage>1499</epage><pages>1495-1499</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary We report a case of anaplastic sarcoma of the kidney (ASK) with cytogenetic findings. A 12-year-old Japanese girl presented with buttock pain and urinary incontinence. Radiological investigations revealed a right renal tumor with multiple distant metastases and multicystic thyroid tumor. She underwent radical right nephrectomy and subsequently received chemotherapy and radiation therapy. Histologically, the renal tumor demonstrated admixture of various types of mesenchymal elements: cellular spindle cells with anaplastic features, cartilage, and rhabdomyoblastic cells consistent with ASK. Chromosomal analysis revealed the karyotype of the tumor cells to be 46, XX, +8, –10, der (18) t (10; 18) (q21; p11.2). The thyroid tumor was removed later and diagnosed as adenomatous goiter. To our knowledge, this is the first case of ASK with chromosomal abnormality and may provide new insight into the molecular biologic basis of this rare renal tumor.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20656319</pmid><doi>10.1016/j.humpath.2010.03.008</doi><tpages>5</tpages></addata></record> |
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| subjects | Anaplastic sarcoma of kidney Biological and medical sciences Cancer Cartilage Chemotherapy Child Children Chromosomal abnormality Chromosome Aberrations Female Goiter - genetics Goiter - pathology Humans Investigative techniques, diagnostic techniques (general aspects) Kidney Neoplasms - genetics Kidney Neoplasms - pathology Kidneys Life sciences Medical sciences Neoplasm Metastasis Neoplasms, Multiple Primary - genetics Neoplasms, Multiple Primary - pathology Nephrology. Urinary tract diseases Pathogenesis Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polymerase chain reaction Renal tumor Sarcoma - genetics Sarcoma - secondary Studies Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Tumors Tumors of the urinary system |
| title | Anaplastic sarcoma of the kidney with chromosomal abnormality: first report on cytogenetic findings |
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