Carnosic acid: A potent chemopreventive agent against oral carcinogenesis
The present study was aimed to investigate the chemopreventive potential of carnosic acid in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. The chemopreventive potential was assessed by analyzing the tumor incidence, tumor volume and burden as well as by measuring...
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| Veröffentlicht in: | Chemico-biological interactions 2010-12, Vol.188 (3), p.616-622 |
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| creator | Manoharan, Shanmugam VasanthaSelvan, MuthamizhSelvan Silvan, Simon Baskaran, Nagarethinam Kumar Singh, Arjun Vinoth Kumar, Veerasamy |
| description | The present study was aimed to investigate the chemopreventive potential of carnosic acid in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. The chemopreventive potential was assessed by analyzing the tumor incidence, tumor volume and burden as well as by measuring the status of lipid peroxidation, non-enzymatic and enzymatic antioxidants and phase I and phase II detoxification enzymes. Oral squamous cell carcinoma was developed in the buccal pouch of golden Syrian hamsters by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. In the present study, 100% tumor formation was observed in hamsters treated with DMBA alone. Also, the status of lipid peroxidation, antioxidants and phase I and phase II detoxification enzymes were significantly altered during DMBA-induced oral carcinogenesis. Oral administration of carnosic acid at a dose of 10
mg/kg body weight/day to DMBA-treated animals completely prevented the tumor formation in the hamsters’ buccal pouches. Also, carnosic acid exerted potent anti-lipid peroxidative function and stimulated the detoxification cascade during DMBA-induced hamster buccal pouch carcinogenesis. The results of the present study suggest that the chemopreventive potential of carnosic acid is probably due to its anti-lipid peroxidative potential and modulating effect on carcinogen detoxification enzymes during DMBA-induced oral carcinogenesis. |
| doi_str_mv | 10.1016/j.cbi.2010.08.009 |
| format | Article |
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mg/kg body weight/day to DMBA-treated animals completely prevented the tumor formation in the hamsters’ buccal pouches. Also, carnosic acid exerted potent anti-lipid peroxidative function and stimulated the detoxification cascade during DMBA-induced hamster buccal pouch carcinogenesis. The results of the present study suggest that the chemopreventive potential of carnosic acid is probably due to its anti-lipid peroxidative potential and modulating effect on carcinogen detoxification enzymes during DMBA-induced oral carcinogenesis.</description><identifier>ISSN: 0009-2797</identifier><identifier>EISSN: 1872-7786</identifier><identifier>DOI: 10.1016/j.cbi.2010.08.009</identifier><identifier>PMID: 20816777</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>9,10-Dimethyl-1,2-benzanthracene - toxicity ; Animals ; Anticarcinogenic Agents - pharmacology ; Antioxidants - metabolism ; Carnosic acid ; Chemoprevention ; Cricetinae ; Diterpenes, Abietane - pharmacology ; DMBA ; Hamsters ; Lipid Peroxidation - drug effects ; Male ; Metabolic Detoxication, Phase I ; Metabolic Detoxication, Phase II ; Mouth Mucosa - drug effects ; Mouth Mucosa - metabolism ; Mouth Neoplasms - chemically induced ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - pathology ; Mouth Neoplasms - prevention & control ; Oral cancer ; Plant Extracts - pharmacology ; Thiobarbituric Acid Reactive Substances - metabolism ; Tumor Burden - drug effects</subject><ispartof>Chemico-biological interactions, 2010-12, Vol.188 (3), p.616-622</ispartof><rights>2010 Elsevier Ireland Ltd</rights><rights>Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-b95856d7abeec9d1ba148666a145ec454f88f9feb25415998568d6e7e45e45b73</citedby><cites>FETCH-LOGICAL-c384t-b95856d7abeec9d1ba148666a145ec454f88f9feb25415998568d6e7e45e45b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cbi.2010.08.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20816777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manoharan, Shanmugam</creatorcontrib><creatorcontrib>VasanthaSelvan, MuthamizhSelvan</creatorcontrib><creatorcontrib>Silvan, Simon</creatorcontrib><creatorcontrib>Baskaran, Nagarethinam</creatorcontrib><creatorcontrib>Kumar Singh, Arjun</creatorcontrib><creatorcontrib>Vinoth Kumar, Veerasamy</creatorcontrib><title>Carnosic acid: A potent chemopreventive agent against oral carcinogenesis</title><title>Chemico-biological interactions</title><addtitle>Chem Biol Interact</addtitle><description>The present study was aimed to investigate the chemopreventive potential of carnosic acid in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. The chemopreventive potential was assessed by analyzing the tumor incidence, tumor volume and burden as well as by measuring the status of lipid peroxidation, non-enzymatic and enzymatic antioxidants and phase I and phase II detoxification enzymes. Oral squamous cell carcinoma was developed in the buccal pouch of golden Syrian hamsters by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. In the present study, 100% tumor formation was observed in hamsters treated with DMBA alone. Also, the status of lipid peroxidation, antioxidants and phase I and phase II detoxification enzymes were significantly altered during DMBA-induced oral carcinogenesis. Oral administration of carnosic acid at a dose of 10
mg/kg body weight/day to DMBA-treated animals completely prevented the tumor formation in the hamsters’ buccal pouches. Also, carnosic acid exerted potent anti-lipid peroxidative function and stimulated the detoxification cascade during DMBA-induced hamster buccal pouch carcinogenesis. The results of the present study suggest that the chemopreventive potential of carnosic acid is probably due to its anti-lipid peroxidative potential and modulating effect on carcinogen detoxification enzymes during DMBA-induced oral carcinogenesis.</description><subject>9,10-Dimethyl-1,2-benzanthracene - toxicity</subject><subject>Animals</subject><subject>Anticarcinogenic Agents - pharmacology</subject><subject>Antioxidants - metabolism</subject><subject>Carnosic acid</subject><subject>Chemoprevention</subject><subject>Cricetinae</subject><subject>Diterpenes, Abietane - pharmacology</subject><subject>DMBA</subject><subject>Hamsters</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Metabolic Detoxication, Phase I</subject><subject>Metabolic Detoxication, Phase II</subject><subject>Mouth Mucosa - drug effects</subject><subject>Mouth Mucosa - metabolism</subject><subject>Mouth Neoplasms - chemically induced</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - prevention & control</subject><subject>Oral cancer</subject><subject>Plant Extracts - pharmacology</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Tumor Burden - drug effects</subject><issn>0009-2797</issn><issn>1872-7786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0EoqXwA7ig3Dgl2KmfcEIVj0qVuMDZcpxNcZXEwU4r8e9x1cKR02p2vx1pBqFrgguCCb_bFLZyRYmTxrLAWJ2gKZGizIWQ_BRNcVrlpVBigi5i3CSJS4rP0aTEknAhxBQtFyb0PjqbGevq--wxG_wI_ZjZT-j8EGCXhNtBZtb7rVkb18cx88G0mTXBut6nA0QXL9FZY9oIV8c5Qx_PT--L13z19rJcPK5yO5d0zCvFJOO1MBWAVTWpDKGSc54GA0sZbaRsVANVyShhSiVY1hwEpDNllZjP0O3Bdwj-awtx1J2LFtrW9OC3UcsUjFLGVCLJgbTBxxig0UNwnQnfmmC9L1BvdCpQ7wvUWOrUVvq5Obpvqw7qv4_fxhLwcAAgZdw5CDpaB72F2gWwo669-8f-B0uMgMM</recordid><startdate>20101205</startdate><enddate>20101205</enddate><creator>Manoharan, Shanmugam</creator><creator>VasanthaSelvan, MuthamizhSelvan</creator><creator>Silvan, Simon</creator><creator>Baskaran, Nagarethinam</creator><creator>Kumar Singh, Arjun</creator><creator>Vinoth Kumar, Veerasamy</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20101205</creationdate><title>Carnosic acid: A potent chemopreventive agent against oral carcinogenesis</title><author>Manoharan, Shanmugam ; VasanthaSelvan, MuthamizhSelvan ; Silvan, Simon ; Baskaran, Nagarethinam ; Kumar Singh, Arjun ; Vinoth Kumar, Veerasamy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-b95856d7abeec9d1ba148666a145ec454f88f9feb25415998568d6e7e45e45b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>9,10-Dimethyl-1,2-benzanthracene - toxicity</topic><topic>Animals</topic><topic>Anticarcinogenic Agents - pharmacology</topic><topic>Antioxidants - metabolism</topic><topic>Carnosic acid</topic><topic>Chemoprevention</topic><topic>Cricetinae</topic><topic>Diterpenes, Abietane - pharmacology</topic><topic>DMBA</topic><topic>Hamsters</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Metabolic Detoxication, Phase I</topic><topic>Metabolic Detoxication, Phase II</topic><topic>Mouth Mucosa - drug effects</topic><topic>Mouth Mucosa - metabolism</topic><topic>Mouth Neoplasms - chemically induced</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mouth Neoplasms - prevention & control</topic><topic>Oral cancer</topic><topic>Plant Extracts - pharmacology</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Tumor Burden - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manoharan, Shanmugam</creatorcontrib><creatorcontrib>VasanthaSelvan, MuthamizhSelvan</creatorcontrib><creatorcontrib>Silvan, Simon</creatorcontrib><creatorcontrib>Baskaran, Nagarethinam</creatorcontrib><creatorcontrib>Kumar Singh, Arjun</creatorcontrib><creatorcontrib>Vinoth Kumar, Veerasamy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Chemico-biological interactions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manoharan, Shanmugam</au><au>VasanthaSelvan, MuthamizhSelvan</au><au>Silvan, Simon</au><au>Baskaran, Nagarethinam</au><au>Kumar Singh, Arjun</au><au>Vinoth Kumar, Veerasamy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carnosic acid: A potent chemopreventive agent against oral carcinogenesis</atitle><jtitle>Chemico-biological interactions</jtitle><addtitle>Chem Biol Interact</addtitle><date>2010-12-05</date><risdate>2010</risdate><volume>188</volume><issue>3</issue><spage>616</spage><epage>622</epage><pages>616-622</pages><issn>0009-2797</issn><eissn>1872-7786</eissn><abstract>The present study was aimed to investigate the chemopreventive potential of carnosic acid in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. The chemopreventive potential was assessed by analyzing the tumor incidence, tumor volume and burden as well as by measuring the status of lipid peroxidation, non-enzymatic and enzymatic antioxidants and phase I and phase II detoxification enzymes. Oral squamous cell carcinoma was developed in the buccal pouch of golden Syrian hamsters by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. In the present study, 100% tumor formation was observed in hamsters treated with DMBA alone. Also, the status of lipid peroxidation, antioxidants and phase I and phase II detoxification enzymes were significantly altered during DMBA-induced oral carcinogenesis. Oral administration of carnosic acid at a dose of 10
mg/kg body weight/day to DMBA-treated animals completely prevented the tumor formation in the hamsters’ buccal pouches. Also, carnosic acid exerted potent anti-lipid peroxidative function and stimulated the detoxification cascade during DMBA-induced hamster buccal pouch carcinogenesis. The results of the present study suggest that the chemopreventive potential of carnosic acid is probably due to its anti-lipid peroxidative potential and modulating effect on carcinogen detoxification enzymes during DMBA-induced oral carcinogenesis.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>20816777</pmid><doi>10.1016/j.cbi.2010.08.009</doi><tpages>7</tpages></addata></record> |
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| subjects | 9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Anticarcinogenic Agents - pharmacology Antioxidants - metabolism Carnosic acid Chemoprevention Cricetinae Diterpenes, Abietane - pharmacology DMBA Hamsters Lipid Peroxidation - drug effects Male Metabolic Detoxication, Phase I Metabolic Detoxication, Phase II Mouth Mucosa - drug effects Mouth Mucosa - metabolism Mouth Neoplasms - chemically induced Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Mouth Neoplasms - prevention & control Oral cancer Plant Extracts - pharmacology Thiobarbituric Acid Reactive Substances - metabolism Tumor Burden - drug effects |
| title | Carnosic acid: A potent chemopreventive agent against oral carcinogenesis |
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