Carcinogenic effect of nickel compounds

Nickel is a widely distributed metal that is industrially applied in many forms. Accumulated epidemiological evidence confirms that exposures to nickel compounds are associated with increased nasal and lung cancer incidence, both in mostly occupational exposures. Although the molecular mechanisms by...

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Veröffentlicht in:	Molecular and cellular biochemistry 2005-11, Vol.279 (1-2), p.45-67
Hauptverfasser:	Lu, Haitian, Shi, Xianglin, Costa, Max, Huang, Chuanshu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis Carcinogens, Environmental - toxicity Cell Transformation, Neoplastic - metabolism DNA Damage Epigenesis, Genetic Humans Lung cancer Mitogen-Activated Protein Kinase 1 - metabolism NF-kappa B - metabolism NFATC Transcription Factors - metabolism Nickel Nickel - toxicity Oxidative stress Reactive Oxygen Species - metabolism Signal Transduction Tumor Suppressor Proteins - metabolism
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