The combined effects of BDE47 and BaP on oxidatively generated DNA damage in L02 cells and the possible molecular mechanism

Polybrominated diphenyl ethers (PBDEs) and polycyclic aromatic hydrocarbons (PAHs) coexist widely in the environment and have generated adverse effects on the environment and human health. The purpose of this study was to investigate the combined toxic effects of these chemicals and the related mech...

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Veröffentlicht in:	Mutation research 2011-04, Vol.721 (2), p.192-198
Hauptverfasser:	An, Jing, Yin, Lingling, Shang, Yu, Zhong, Yufang, Zhang, Xinyu, Wu, Minghong, Yu, Zhiqiang, Sheng, Guoying, Fu, Jiamo, Huang, Yuecheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Aryl Hydrocarbon Hydroxylases - metabolism BaP BDE47 Benzo(a)pyrene - administration & dosage Benzo(a)pyrene - toxicity Biological and medical sciences Cell growth Cell Line, Transformed Cell Proliferation - drug effects Cell Survival - drug effects CYP1 Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1B1 DNA Damage DNA strand break Environmental impact Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Halogenated Diphenyl Ethers - administration & dosage Halogenated Diphenyl Ethers - toxicity Human exposure Humans Hydro-Lyases - metabolism Medical sciences Metabolism Mutagens - toxicity Oxidative stress Oxidative Stress - drug effects Polycyclic aromatic hydrocarbons Toxicity Toxicology
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