Granulocyte-colony stimulating factor ameliorates irradiation-induced suppression of hippocampal neurogenesis in adult mice

▶ Granulocyte-colony stimulating factor (G-csf) demonstrates neuroprotective functions in neurodegenerative diseases. ▶ Cranial irradiation induces neural apoptosis and inhibits neurogenesis in the dentate gyrus of the adult mouse hippocampus. ▶ Pretreatment with G-csf attenuated neural apoptosis an...

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Veröffentlicht in:	Neuroscience letters 2010-12, Vol.486 (1), p.43-46
Hauptverfasser:	Kim, Joong-Sun, Yang, Miyoung, Jang, Hyosun, Oui, Heejin, Kim, Sung-Ho, Shin, Taekyun, Jang, Won-Suk, Lee, Seung-Sook, Moon, Changjong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - radiation effects Biological and medical sciences Cranial Irradiation - adverse effects Dentate Gyrus - drug effects Dentate Gyrus - metabolism Dentate Gyrus - radiation effects Fundamental and applied biological sciences. Psychology G-csf Granulocyte Colony-Stimulating Factor - pharmacology Hippocampus Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Hippocampus - radiation effects Irradiation Ki-67 Antigen - metabolism Male Mice Mice, Inbred C3H Microtubule-Associated Proteins - metabolism Neurogenesis Neurogenesis - drug effects Neuropeptides - metabolism Neuroprotective Agents - pharmacology Radiation-Protective Agents - pharmacology Recombinant Proteins Vertebrates: nervous system and sense organs
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