Glycyrrhiza flavescens subsp. antalyensis exerts antiproliferative effects on melanoma cells via altering TNF-α and IFN-α levels
Glycyrrhiza species possess preventive and therapeutic potentials against various cancers. In the present study, we have evaluated regulation of apoptotic cell death by aqueous extracts of leaf and flower of an endemic Glycyrrhiza species; Glycyrrhiza flavescens subsp. antalyensis, in mouse melanoma...
Gespeichert in:
| Veröffentlicht in: | Food and chemical toxicology 2011-04, Vol.49 (4), p.820-828 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 828 |
|---|---|
| container_issue | 4 |
| container_start_page | 820 |
| container_title | Food and chemical toxicology |
| container_volume | 49 |
| creator | Aydemir, Esra Arslan Oz, Ece Simsek Göktürk, Ramazan Süleyman Ozkan, Gülcan Fiskin, Kayahan |
| description | Glycyrrhiza species possess preventive and therapeutic potentials against various cancers. In the present study, we have evaluated regulation of apoptotic cell death by aqueous extracts of leaf and flower of an endemic
Glycyrrhiza species;
Glycyrrhiza flavescens subsp.
antalyensis, in mouse melanoma cell lines. Both leaf and flower extracts induced apoptosis in terms of induction of caspase-3 activity, TNF-α and IFN-γ release. Concentrations of both TNF-α and IFN-γ in extract-treated groups were significantly and dose dependently exalted as compared to their relative controls. The effects of extracts on caspase-3, TNF-α and IFN-γ processes mediate the plausible mechanism of apoptosis induction of
G. flavescens subsp.
antalyensis. |
| doi_str_mv | 10.1016/j.fct.2010.12.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_867739587</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0278691510007088</els_id><sourcerecordid>856406665</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-f582aec99e8af5718516f99601b33e4f5c494d42581647b0f034c060dd3195c23</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhS0EokPhAdiAN4hVgh3_xBYrVDGlUlUWtGvL41wXj5xksDMRw5I34kV4JhzNADtY2b7-zr1H9yD0nJKaEirfbGvvprohy7upCWEP0IqqllWSCfoQrUjTqkpqKs7Qk5y3hJCWtvIxOmso5UIzsULfL-PBHVL6HL5Z7KOdITsYMs77Td7V2A6TjYdSCBnDV0hTXkphl8YYPCQ7hRkweA-u_IwD7iHaYewtdhBjxnOw2MYJUhju8e3Nuvr5o-g7fLW-Wa4RZoj5KXrkbczw7HSeo7v1-9uLD9X1x8uri3fXleNMTZUXqrHgtAZlvWipElR6rSWhG8aAe-G45h1vhKKStxviCeOOSNJ1jGrhGnaOXh_7Fvdf9pAn04e8-LQDjPtslGxbpkXZ339JITmRUopC0iPp0phzAm92KfQ2HQwlZsnIbE3JyCwZGdqYklHRvDh132966P4ofodSgFcnwGZno092cCH_5ZjmSnFeuJdHztvR2PtUmLtPZZIghLacMlKIt0eirBnmAMlkF2Bw0IVUIjPdGP5h9BcVSrnF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>856406665</pqid></control><display><type>article</type><title>Glycyrrhiza flavescens subsp. antalyensis exerts antiproliferative effects on melanoma cells via altering TNF-α and IFN-α levels</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Aydemir, Esra Arslan ; Oz, Ece Simsek ; Göktürk, Ramazan Süleyman ; Ozkan, Gülcan ; Fiskin, Kayahan</creator><creatorcontrib>Aydemir, Esra Arslan ; Oz, Ece Simsek ; Göktürk, Ramazan Süleyman ; Ozkan, Gülcan ; Fiskin, Kayahan</creatorcontrib><description>Glycyrrhiza species possess preventive and therapeutic potentials against various cancers. In the present study, we have evaluated regulation of apoptotic cell death by aqueous extracts of leaf and flower of an endemic
Glycyrrhiza species;
Glycyrrhiza flavescens subsp.
antalyensis, in mouse melanoma cell lines. Both leaf and flower extracts induced apoptosis in terms of induction of caspase-3 activity, TNF-α and IFN-γ release. Concentrations of both TNF-α and IFN-γ in extract-treated groups were significantly and dose dependently exalted as compared to their relative controls. The effects of extracts on caspase-3, TNF-α and IFN-γ processes mediate the plausible mechanism of apoptosis induction of
G. flavescens subsp.
antalyensis.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2010.12.003</identifier><identifier>PMID: 21145935</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Apoptosis ; Biological and medical sciences ; Caspase ; caspase-3 ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Dermatology ; flowers ; General pharmacology ; Glycyrrhiza ; Glycyrrhiza - chemistry ; interferon-alpha ; Interferon-alpha - metabolism ; Interferon-gamma ; leaf extracts ; leaves ; Medical sciences ; Melanoma ; Melanoma, Experimental - metabolism ; Melanoma, Experimental - pathology ; Mice ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - pharmacology ; toxicology ; Tumor necrosis factor ; tumor necrosis factor-alpha ; Tumor Necrosis Factor-alpha - metabolism ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Food and chemical toxicology, 2011-04, Vol.49 (4), p.820-828</ispartof><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-f582aec99e8af5718516f99601b33e4f5c494d42581647b0f034c060dd3195c23</citedby><cites>FETCH-LOGICAL-c438t-f582aec99e8af5718516f99601b33e4f5c494d42581647b0f034c060dd3195c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278691510007088$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23948844$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21145935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aydemir, Esra Arslan</creatorcontrib><creatorcontrib>Oz, Ece Simsek</creatorcontrib><creatorcontrib>Göktürk, Ramazan Süleyman</creatorcontrib><creatorcontrib>Ozkan, Gülcan</creatorcontrib><creatorcontrib>Fiskin, Kayahan</creatorcontrib><title>Glycyrrhiza flavescens subsp. antalyensis exerts antiproliferative effects on melanoma cells via altering TNF-α and IFN-α levels</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Glycyrrhiza species possess preventive and therapeutic potentials against various cancers. In the present study, we have evaluated regulation of apoptotic cell death by aqueous extracts of leaf and flower of an endemic
Glycyrrhiza species;
Glycyrrhiza flavescens subsp.
antalyensis, in mouse melanoma cell lines. Both leaf and flower extracts induced apoptosis in terms of induction of caspase-3 activity, TNF-α and IFN-γ release. Concentrations of both TNF-α and IFN-γ in extract-treated groups were significantly and dose dependently exalted as compared to their relative controls. The effects of extracts on caspase-3, TNF-α and IFN-γ processes mediate the plausible mechanism of apoptosis induction of
G. flavescens subsp.
antalyensis.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Caspase</subject><subject>caspase-3</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Dermatology</subject><subject>flowers</subject><subject>General pharmacology</subject><subject>Glycyrrhiza</subject><subject>Glycyrrhiza - chemistry</subject><subject>interferon-alpha</subject><subject>Interferon-alpha - metabolism</subject><subject>Interferon-gamma</subject><subject>leaf extracts</subject><subject>leaves</subject><subject>Medical sciences</subject><subject>Melanoma</subject><subject>Melanoma, Experimental - metabolism</subject><subject>Melanoma, Experimental - pathology</subject><subject>Mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - pharmacology</subject><subject>toxicology</subject><subject>Tumor necrosis factor</subject><subject>tumor necrosis factor-alpha</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EokPhAdiAN4hVgh3_xBYrVDGlUlUWtGvL41wXj5xksDMRw5I34kV4JhzNADtY2b7-zr1H9yD0nJKaEirfbGvvprohy7upCWEP0IqqllWSCfoQrUjTqkpqKs7Qk5y3hJCWtvIxOmso5UIzsULfL-PBHVL6HL5Z7KOdITsYMs77Td7V2A6TjYdSCBnDV0hTXkphl8YYPCQ7hRkweA-u_IwD7iHaYewtdhBjxnOw2MYJUhju8e3Nuvr5o-g7fLW-Wa4RZoj5KXrkbczw7HSeo7v1-9uLD9X1x8uri3fXleNMTZUXqrHgtAZlvWipElR6rSWhG8aAe-G45h1vhKKStxviCeOOSNJ1jGrhGnaOXh_7Fvdf9pAn04e8-LQDjPtslGxbpkXZ339JITmRUopC0iPp0phzAm92KfQ2HQwlZsnIbE3JyCwZGdqYklHRvDh132966P4ofodSgFcnwGZno092cCH_5ZjmSnFeuJdHztvR2PtUmLtPZZIghLacMlKIt0eirBnmAMlkF2Bw0IVUIjPdGP5h9BcVSrnF</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Aydemir, Esra Arslan</creator><creator>Oz, Ece Simsek</creator><creator>Göktürk, Ramazan Süleyman</creator><creator>Ozkan, Gülcan</creator><creator>Fiskin, Kayahan</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20110401</creationdate><title>Glycyrrhiza flavescens subsp. antalyensis exerts antiproliferative effects on melanoma cells via altering TNF-α and IFN-α levels</title><author>Aydemir, Esra Arslan ; Oz, Ece Simsek ; Göktürk, Ramazan Süleyman ; Ozkan, Gülcan ; Fiskin, Kayahan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-f582aec99e8af5718516f99601b33e4f5c494d42581647b0f034c060dd3195c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Caspase</topic><topic>caspase-3</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Dermatology</topic><topic>flowers</topic><topic>General pharmacology</topic><topic>Glycyrrhiza</topic><topic>Glycyrrhiza - chemistry</topic><topic>interferon-alpha</topic><topic>Interferon-alpha - metabolism</topic><topic>Interferon-gamma</topic><topic>leaf extracts</topic><topic>leaves</topic><topic>Medical sciences</topic><topic>Melanoma</topic><topic>Melanoma, Experimental - metabolism</topic><topic>Melanoma, Experimental - pathology</topic><topic>Mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - pharmacology</topic><topic>toxicology</topic><topic>Tumor necrosis factor</topic><topic>tumor necrosis factor-alpha</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aydemir, Esra Arslan</creatorcontrib><creatorcontrib>Oz, Ece Simsek</creatorcontrib><creatorcontrib>Göktürk, Ramazan Süleyman</creatorcontrib><creatorcontrib>Ozkan, Gülcan</creatorcontrib><creatorcontrib>Fiskin, Kayahan</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aydemir, Esra Arslan</au><au>Oz, Ece Simsek</au><au>Göktürk, Ramazan Süleyman</au><au>Ozkan, Gülcan</au><au>Fiskin, Kayahan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycyrrhiza flavescens subsp. antalyensis exerts antiproliferative effects on melanoma cells via altering TNF-α and IFN-α levels</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>49</volume><issue>4</issue><spage>820</spage><epage>828</epage><pages>820-828</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>Glycyrrhiza species possess preventive and therapeutic potentials against various cancers. In the present study, we have evaluated regulation of apoptotic cell death by aqueous extracts of leaf and flower of an endemic
Glycyrrhiza species;
Glycyrrhiza flavescens subsp.
antalyensis, in mouse melanoma cell lines. Both leaf and flower extracts induced apoptosis in terms of induction of caspase-3 activity, TNF-α and IFN-γ release. Concentrations of both TNF-α and IFN-γ in extract-treated groups were significantly and dose dependently exalted as compared to their relative controls. The effects of extracts on caspase-3, TNF-α and IFN-γ processes mediate the plausible mechanism of apoptosis induction of
G. flavescens subsp.
antalyensis.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>21145935</pmid><doi>10.1016/j.fct.2010.12.003</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 2011-04, Vol.49 (4), p.820-828 |
| issn | 0278-6915 1873-6351 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_867739587 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Apoptosis Biological and medical sciences Caspase caspase-3 Cell Line, Tumor Cell Proliferation - drug effects Dermatology flowers General pharmacology Glycyrrhiza Glycyrrhiza - chemistry interferon-alpha Interferon-alpha - metabolism Interferon-gamma leaf extracts leaves Medical sciences Melanoma Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology toxicology Tumor necrosis factor tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - metabolism Tumors of the skin and soft tissue. Premalignant lesions |
| title | Glycyrrhiza flavescens subsp. antalyensis exerts antiproliferative effects on melanoma cells via altering TNF-α and IFN-α levels |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T15%3A48%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glycyrrhiza%20flavescens%20subsp.%20antalyensis%20exerts%20antiproliferative%20effects%20on%20melanoma%20cells%20via%20altering%20TNF-%CE%B1%20and%20IFN-%CE%B1%20levels&rft.jtitle=Food%20and%20chemical%20toxicology&rft.au=Aydemir,%20Esra%20Arslan&rft.date=2011-04-01&rft.volume=49&rft.issue=4&rft.spage=820&rft.epage=828&rft.pages=820-828&rft.issn=0278-6915&rft.eissn=1873-6351&rft.coden=FCTOD7&rft_id=info:doi/10.1016/j.fct.2010.12.003&rft_dat=%3Cproquest_cross%3E856406665%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=856406665&rft_id=info:pmid/21145935&rft_els_id=S0278691510007088&rfr_iscdi=true |