Lipids and Age-related Macular Degeneration
Abstract Given the considerable public health burden imposed by age-related macular degeneration (AMD), much effort has been directed towards elucidating principles of pathogenesis in order to identify risk factors and develop preventive measures and treatments. Together with epidemiological evidenc...
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| Veröffentlicht in: | Survey of ophthalmology 2011-05, Vol.56 (3), p.195-213 |
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| creator | Kishan, Amar U., BA Modjtahedi, Bobeck S., MD Martins, Elisabeth N., MD Modjtahedi, Sara P., MD Morse, Lawrence S., MD, PhD |
| description | Abstract Given the considerable public health burden imposed by age-related macular degeneration (AMD), much effort has been directed towards elucidating principles of pathogenesis in order to identify risk factors and develop preventive measures and treatments. Together with epidemiological evidence linking cardiovascular risk factors with AMD risk and basic science work examining the role of lipid metabolism in AMD, numerous human studies have assayed a potential relationship between dietary lipids and the development of AMD. We examine the evidence for a role for lipid metabolism in AMD, highlighting key basic biochemical principles, work in animal models, and relevant human studies. The topics of lipoprotein modulation and omega-3 fatty acid intake receive special attention from both a basic science and clinical study standpoint. The evidence suggests that consumption of omega-3 fatty acids, perhaps in concert with antioxidants, may constitute a rational preventative strategy against AMD development, though, absent an appropriately developed double-blind, randomized control trial, insufficient data exist to recommend implementation in the clinical setting at this time. |
| doi_str_mv | 10.1016/j.survophthal.2010.08.008 |
| format | Article |
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Together with epidemiological evidence linking cardiovascular risk factors with AMD risk and basic science work examining the role of lipid metabolism in AMD, numerous human studies have assayed a potential relationship between dietary lipids and the development of AMD. We examine the evidence for a role for lipid metabolism in AMD, highlighting key basic biochemical principles, work in animal models, and relevant human studies. The topics of lipoprotein modulation and omega-3 fatty acid intake receive special attention from both a basic science and clinical study standpoint. The evidence suggests that consumption of omega-3 fatty acids, perhaps in concert with antioxidants, may constitute a rational preventative strategy against AMD development, though, absent an appropriately developed double-blind, randomized control trial, insufficient data exist to recommend implementation in the clinical setting at this time.</description><identifier>ISSN: 0039-6257</identifier><identifier>EISSN: 1879-3304</identifier><identifier>DOI: 10.1016/j.survophthal.2010.08.008</identifier><identifier>PMID: 21439604</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age-related macular degeneration ; Animals ; cholesterol ; diet ; Dietary Fats - administration & dosage ; docosahexaenoic acid ; eicosapentaenoic acid ; human ; Humans ; Lipid Metabolism - physiology ; lipids ; Macular Degeneration - metabolism ; Macular Degeneration - prevention & control ; metabolism ; omega-3 ; Ophthalmology ; Risk Factors ; statin</subject><ispartof>Survey of ophthalmology, 2011-05, Vol.56 (3), p.195-213</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. 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Together with epidemiological evidence linking cardiovascular risk factors with AMD risk and basic science work examining the role of lipid metabolism in AMD, numerous human studies have assayed a potential relationship between dietary lipids and the development of AMD. We examine the evidence for a role for lipid metabolism in AMD, highlighting key basic biochemical principles, work in animal models, and relevant human studies. The topics of lipoprotein modulation and omega-3 fatty acid intake receive special attention from both a basic science and clinical study standpoint. The evidence suggests that consumption of omega-3 fatty acids, perhaps in concert with antioxidants, may constitute a rational preventative strategy against AMD development, though, absent an appropriately developed double-blind, randomized control trial, insufficient data exist to recommend implementation in the clinical setting at this time.</description><subject>Age-related macular degeneration</subject><subject>Animals</subject><subject>cholesterol</subject><subject>diet</subject><subject>Dietary Fats - administration & dosage</subject><subject>docosahexaenoic acid</subject><subject>eicosapentaenoic acid</subject><subject>human</subject><subject>Humans</subject><subject>Lipid Metabolism - physiology</subject><subject>lipids</subject><subject>Macular Degeneration - metabolism</subject><subject>Macular Degeneration - prevention & control</subject><subject>metabolism</subject><subject>omega-3</subject><subject>Ophthalmology</subject><subject>Risk Factors</subject><subject>statin</subject><issn>0039-6257</issn><issn>1879-3304</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1LxDAQhoMoun78BVlPHqTrJGnT9CLI-gkrHtRzSJOJZu22a9IK_nuzrIp48jTD8MwMPC8hRxQmFKg4nU_iEN675Uv_opsJgzQHOQGQG2REZVllnEO-SUYAvMoEK8odshvjHAByXpXbZIfR1AjIR-Rk5pfexrFu7fj8GbOAje7Rju-0GRodxhf4jC0G3fuu3SdbTjcRD77qHnm6unyc3mSz--vb6fksM7ngfSaMcbXRjgpqa1HkgDXkhRNOMCsM01w7KXVd1Q5Kic5Q4JTXWjMmbVHbnO-R4_XdZejeBoy9WvhosGl0i90QlRRlyYuKyn-QrKygYiKR1Zo0oYsxoFPL4Bc6fCgKaiVVzdUvqWolVYFUSWraPfz6MtQLtD-b3xYTMF0DmKy8ewwqGo-tQesDml7Zzv_rzdmfK6bxrTe6ecUPjPNuCG3SrqiKTIF6WKW7CpemXGnSwT8Bz7Wi-A</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Kishan, Amar U., BA</creator><creator>Modjtahedi, Bobeck S., MD</creator><creator>Martins, Elisabeth N., MD</creator><creator>Modjtahedi, Sara P., MD</creator><creator>Morse, Lawrence S., MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20110501</creationdate><title>Lipids and Age-related Macular Degeneration</title><author>Kishan, Amar U., BA ; Modjtahedi, Bobeck S., MD ; Martins, Elisabeth N., MD ; Modjtahedi, Sara P., MD ; Morse, Lawrence S., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-6ccfbcaf161db6540eb045f6f62d6c2a3af88ab9bf078efc10313baa228d5bd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age-related macular degeneration</topic><topic>Animals</topic><topic>cholesterol</topic><topic>diet</topic><topic>Dietary Fats - administration & dosage</topic><topic>docosahexaenoic acid</topic><topic>eicosapentaenoic acid</topic><topic>human</topic><topic>Humans</topic><topic>Lipid Metabolism - physiology</topic><topic>lipids</topic><topic>Macular Degeneration - metabolism</topic><topic>Macular Degeneration - prevention & control</topic><topic>metabolism</topic><topic>omega-3</topic><topic>Ophthalmology</topic><topic>Risk Factors</topic><topic>statin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kishan, Amar U., BA</creatorcontrib><creatorcontrib>Modjtahedi, Bobeck S., MD</creatorcontrib><creatorcontrib>Martins, Elisabeth N., MD</creatorcontrib><creatorcontrib>Modjtahedi, Sara P., MD</creatorcontrib><creatorcontrib>Morse, Lawrence S., MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Survey of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kishan, Amar U., BA</au><au>Modjtahedi, Bobeck S., MD</au><au>Martins, Elisabeth N., MD</au><au>Modjtahedi, Sara P., MD</au><au>Morse, Lawrence S., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipids and Age-related Macular Degeneration</atitle><jtitle>Survey of ophthalmology</jtitle><addtitle>Surv Ophthalmol</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>56</volume><issue>3</issue><spage>195</spage><epage>213</epage><pages>195-213</pages><issn>0039-6257</issn><eissn>1879-3304</eissn><abstract>Abstract Given the considerable public health burden imposed by age-related macular degeneration (AMD), much effort has been directed towards elucidating principles of pathogenesis in order to identify risk factors and develop preventive measures and treatments. Together with epidemiological evidence linking cardiovascular risk factors with AMD risk and basic science work examining the role of lipid metabolism in AMD, numerous human studies have assayed a potential relationship between dietary lipids and the development of AMD. We examine the evidence for a role for lipid metabolism in AMD, highlighting key basic biochemical principles, work in animal models, and relevant human studies. The topics of lipoprotein modulation and omega-3 fatty acid intake receive special attention from both a basic science and clinical study standpoint. The evidence suggests that consumption of omega-3 fatty acids, perhaps in concert with antioxidants, may constitute a rational preventative strategy against AMD development, though, absent an appropriately developed double-blind, randomized control trial, insufficient data exist to recommend implementation in the clinical setting at this time.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21439604</pmid><doi>10.1016/j.survophthal.2010.08.008</doi><tpages>19</tpages></addata></record> |
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| ispartof | Survey of ophthalmology, 2011-05, Vol.56 (3), p.195-213 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Age-related macular degeneration Animals cholesterol diet Dietary Fats - administration & dosage docosahexaenoic acid eicosapentaenoic acid human Humans Lipid Metabolism - physiology lipids Macular Degeneration - metabolism Macular Degeneration - prevention & control metabolism omega-3 Ophthalmology Risk Factors statin |
| title | Lipids and Age-related Macular Degeneration |
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