Effect of the synthetic coumarin, ethyl 2-oxo-2H-chromene-3-carboxylate, on activity of Crotalus durissus ruruima sPLA2 as well as on edema and platelet aggregation induced by this factor

We show that ethyl 2-oxo-2H-chromene-3-carboxylate (EOCC), a synthetic coumarin, irreversibly inhibits phospholipase A 2 (sPLA2) from Crotalus durissus ruruima venom (sPLA2r) with an IC 50 of 3.1 ± 0.06 nmol. EOCC strongly decreased the V max and K m, and it virtually abolished the enzyme activity o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicon (Oxford) 2010-07, Vol.55 (8), p.1527-1530
Hauptverfasser:	Fonseca, F.V., Baldissera, L., Camargo, E.A., Antunes, E., Diz-Filho, E.B.S., Corrêa, A.G., Beriam, L.O.S., Toyama, D.O., Cotrim, C.A., Toyama, M.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antivenins - pharmacology Coumarins - pharmacology Crotalid Venoms - enzymology Crotalus - physiology Crotalus durissus Crotalus durissus ruruima Edema Edema - chemically induced Edema - prevention & control Enzyme Inhibitors - pharmacology Male Myonecrosis Phospholipase A2 Inhibitors Phospholipases A2 - pharmacology Platelet Platelet Aggregation - drug effects Rats Rats, Wistar sPLA2 Synthetic coumarin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!