First births after preimplantation genetic diagnosis of structural chromosome abnormalities using comparative genomic hybridization and microarray analysis

BACKGROUND Balanced chromosomal rearrangements represent one of the most frequent indications for preimplantation genetic diagnosis (PGD). Although fluorescence in situ hybridization (FISH) has been successfully employed for diagnosis in such cases, this approach usually restricts assessment of the...

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Veröffentlicht in:	Human reproduction (Oxford) 2011-06, Vol.26 (6), p.1560-1574
Hauptverfasser:	Alfarawati, S., Fragouli, E., Colls, P., Wells, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Birth Order Chromosome Aberrations Chromosome Inversion - genetics Comparative Genomic Hybridization Female Genetic Diseases, Inborn - diagnosis Gynecology. Andrology. Obstetrics Humans In Situ Hybridization, Fluorescence Medical sciences Microarray Analysis Pregnancy Preimplantation Diagnosis - methods Translocation, Genetic - genetics
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