The value of FDG PET/CT in the initial staging and bone marrow involvement of patients with multiple myeloma
Objective The aim of this study was to describe the role of positron emission tomography/computed tomography (PET/CT) with fluorine-18 fluorodeoxyglucose (FDG) in the detection of skeletal and visceral involvement in patients with MM (multiple myeloma) at the initial diagnosis and to evaluate the re...
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| Veröffentlicht in: | Skeletal radiology 2011-07, Vol.40 (7), p.843-847 |
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| creator | Sager, Sait Ergül, Nurhan Ciftci, Hediye Cetin, Güven Güner, Sebnem İzmir Cermik, Teyfik Fikret |
| description | Objective
The aim of this study was to describe the role of positron emission tomography/computed tomography (PET/CT) with fluorine-18 fluorodeoxyglucose (FDG) in the detection of skeletal and visceral involvement in patients with MM (multiple myeloma) at the initial diagnosis and to evaluate the relation between maximum standardized uptake values (SUVmax) of FDG with bone marrow cellularity and plasma cell ratios.
Materials and methods
The study population consisted of 42 patients (15 F, 28 M; mean ± SD age; 47 ± 12 years). Thirty-two patients were referred for initial diagnosis and ten patients were referred for assessment of therapy response. PET/CT scan was obtained 60 min after the administration of 5.4 MBq/kg FDG. The SUVmax of FDG uptake was measured from the region of interest, which was placed at the site of most prominent lesion in bone marrow in PET/CT images.
Results
Thirty patients were positive (29 of 32 initially diagnosed, one of ten previously treated) and 12 patients were negative on PET/CT scan. Conventional radiological methods were negative in three of 30 FDG PET/CT-positive patients and these methods did not show any pathological finding in 12 FDG PET/CT-negative patients. The sensitivity of FDG PET in detecting bone marrow involvement at initial diagnosis was 90%. There was a significant correlation between SUVmax values and bone marrow biopsy cellularity and plasma cell ratios, (
r
= 0.54 and
r
= 0.74,
p
< 0.01).
Conclusions
The results of this study demonstrated that FDG-PET is a useful technique for the assessment of MM and the correlation between SUVmax and plasma cell ratios in bone marrow biopsy may avoid repeated bone marrow biopsies in the follow-up period. |
| doi_str_mv | 10.1007/s00256-010-1088-9 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_867728564</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A730893008</galeid><sourcerecordid>A730893008</sourcerecordid><originalsourceid>FETCH-LOGICAL-c467t-88ece0c719bad8e37009f28a1f6a4e17f398f4a32966bbb5d8bcec7985f985d13</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhiMEokvhB3BBFghxSjv-iO0cq6UtSJXgsJwtx7G3rhxniZ2t-u_xkoUKBLIsf8zzvh7PVNVrDGcYQJwnANLwGjDUGKSs2yfVCjNKaoI5flqtgHJWE8rkSfUipTsALETDn1cnBBPS0oatqrC5tWivw2zR6NDVx2v09XJzvt4gH1EuIR999jqglPXWxy3SsUfdGC0a9DSN9yW-H8PeDjbmg8FOZ1-2Cd37fIuGOWS_CwV-sGEc9MvqmdMh2VfH9bT6dnW5WX-qb75cf15f3NSGcZFrKa2xYARuO91LSwVA64jU2HHNLBaOttIxTUnLedd1TS87Y41oZePK7DE9rT4svrtp_D7blNXgk7Eh6GjHOSnJhSCy4ayQb_8i78Z5iiW5AwREYgYFerdAWx2s8tGNedLmYKkuBAXZUgBZqLN_UGX0dvCmlMz5cv-HAC8CM40pTdap3eRLWR8UBnXor1r6q-DnWUrVFs2bY75zN9j-t-JXQwvw_gjoZHRwk47Gp0eOEUIxJoUjC5dKKG7t9Pjx_7_-Azd8usM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>867028140</pqid></control><display><type>article</type><title>The value of FDG PET/CT in the initial staging and bone marrow involvement of patients with multiple myeloma</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Sager, Sait ; Ergül, Nurhan ; Ciftci, Hediye ; Cetin, Güven ; Güner, Sebnem İzmir ; Cermik, Teyfik Fikret</creator><creatorcontrib>Sager, Sait ; Ergül, Nurhan ; Ciftci, Hediye ; Cetin, Güven ; Güner, Sebnem İzmir ; Cermik, Teyfik Fikret</creatorcontrib><description>Objective
The aim of this study was to describe the role of positron emission tomography/computed tomography (PET/CT) with fluorine-18 fluorodeoxyglucose (FDG) in the detection of skeletal and visceral involvement in patients with MM (multiple myeloma) at the initial diagnosis and to evaluate the relation between maximum standardized uptake values (SUVmax) of FDG with bone marrow cellularity and plasma cell ratios.
Materials and methods
The study population consisted of 42 patients (15 F, 28 M; mean ± SD age; 47 ± 12 years). Thirty-two patients were referred for initial diagnosis and ten patients were referred for assessment of therapy response. PET/CT scan was obtained 60 min after the administration of 5.4 MBq/kg FDG. The SUVmax of FDG uptake was measured from the region of interest, which was placed at the site of most prominent lesion in bone marrow in PET/CT images.
Results
Thirty patients were positive (29 of 32 initially diagnosed, one of ten previously treated) and 12 patients were negative on PET/CT scan. Conventional radiological methods were negative in three of 30 FDG PET/CT-positive patients and these methods did not show any pathological finding in 12 FDG PET/CT-negative patients. The sensitivity of FDG PET in detecting bone marrow involvement at initial diagnosis was 90%. There was a significant correlation between SUVmax values and bone marrow biopsy cellularity and plasma cell ratios, (
r
= 0.54 and
r
= 0.74,
p
< 0.01).
Conclusions
The results of this study demonstrated that FDG-PET is a useful technique for the assessment of MM and the correlation between SUVmax and plasma cell ratios in bone marrow biopsy may avoid repeated bone marrow biopsies in the follow-up period.</description><identifier>ISSN: 0364-2348</identifier><identifier>EISSN: 1432-2161</identifier><identifier>DOI: 10.1007/s00256-010-1088-9</identifier><identifier>PMID: 21229354</identifier><identifier>CODEN: SKRADI</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Bone Marrow - diagnostic imaging ; Bone Marrow - pathology ; Care and treatment ; Female ; Fluorine compounds ; Fluorodeoxyglucose F18 ; Hematologic and hematopoietic diseases ; Humans ; Imaging ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulinopathies ; Immunopathology ; Investigative techniques, diagnostic techniques (general aspects) ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical research ; Medical sciences ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Multiple myeloma ; Multiple Myeloma - diagnostic imaging ; Multiple Myeloma - pathology ; Neoplasm Staging ; Nuclear Medicine ; Orthopedics ; Osteoarticular system. Muscles ; Pathology ; PET imaging ; Positron-Emission Tomography - methods ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Radiology ; Radiopharmaceuticals ; Reproducibility of Results ; Scientific Article ; Sensitivity and Specificity ; Tomography, X-Ray Computed - methods ; Young Adult</subject><ispartof>Skeletal radiology, 2011-07, Vol.40 (7), p.843-847</ispartof><rights>ISS 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-88ece0c719bad8e37009f28a1f6a4e17f398f4a32966bbb5d8bcec7985f985d13</citedby><cites>FETCH-LOGICAL-c467t-88ece0c719bad8e37009f28a1f6a4e17f398f4a32966bbb5d8bcec7985f985d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00256-010-1088-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00256-010-1088-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24223112$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21229354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sager, Sait</creatorcontrib><creatorcontrib>Ergül, Nurhan</creatorcontrib><creatorcontrib>Ciftci, Hediye</creatorcontrib><creatorcontrib>Cetin, Güven</creatorcontrib><creatorcontrib>Güner, Sebnem İzmir</creatorcontrib><creatorcontrib>Cermik, Teyfik Fikret</creatorcontrib><title>The value of FDG PET/CT in the initial staging and bone marrow involvement of patients with multiple myeloma</title><title>Skeletal radiology</title><addtitle>Skeletal Radiol</addtitle><addtitle>Skeletal Radiol</addtitle><description>Objective
The aim of this study was to describe the role of positron emission tomography/computed tomography (PET/CT) with fluorine-18 fluorodeoxyglucose (FDG) in the detection of skeletal and visceral involvement in patients with MM (multiple myeloma) at the initial diagnosis and to evaluate the relation between maximum standardized uptake values (SUVmax) of FDG with bone marrow cellularity and plasma cell ratios.
Materials and methods
The study population consisted of 42 patients (15 F, 28 M; mean ± SD age; 47 ± 12 years). Thirty-two patients were referred for initial diagnosis and ten patients were referred for assessment of therapy response. PET/CT scan was obtained 60 min after the administration of 5.4 MBq/kg FDG. The SUVmax of FDG uptake was measured from the region of interest, which was placed at the site of most prominent lesion in bone marrow in PET/CT images.
Results
Thirty patients were positive (29 of 32 initially diagnosed, one of ten previously treated) and 12 patients were negative on PET/CT scan. Conventional radiological methods were negative in three of 30 FDG PET/CT-positive patients and these methods did not show any pathological finding in 12 FDG PET/CT-negative patients. The sensitivity of FDG PET in detecting bone marrow involvement at initial diagnosis was 90%. There was a significant correlation between SUVmax values and bone marrow biopsy cellularity and plasma cell ratios, (
r
= 0.54 and
r
= 0.74,
p
< 0.01).
Conclusions
The results of this study demonstrated that FDG-PET is a useful technique for the assessment of MM and the correlation between SUVmax and plasma cell ratios in bone marrow biopsy may avoid repeated bone marrow biopsies in the follow-up period.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - diagnostic imaging</subject><subject>Bone Marrow - pathology</subject><subject>Care and treatment</subject><subject>Female</subject><subject>Fluorine compounds</subject><subject>Fluorodeoxyglucose F18</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Imaging</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - diagnostic imaging</subject><subject>Multiple Myeloma - pathology</subject><subject>Neoplasm Staging</subject><subject>Nuclear Medicine</subject><subject>Orthopedics</subject><subject>Osteoarticular system. Muscles</subject><subject>Pathology</subject><subject>PET imaging</subject><subject>Positron-Emission Tomography - methods</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Radiology</subject><subject>Radiopharmaceuticals</subject><subject>Reproducibility of Results</subject><subject>Scientific Article</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Young Adult</subject><issn>0364-2348</issn><issn>1432-2161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1v1DAQhiMEokvhB3BBFghxSjv-iO0cq6UtSJXgsJwtx7G3rhxniZ2t-u_xkoUKBLIsf8zzvh7PVNVrDGcYQJwnANLwGjDUGKSs2yfVCjNKaoI5flqtgHJWE8rkSfUipTsALETDn1cnBBPS0oatqrC5tWivw2zR6NDVx2v09XJzvt4gH1EuIR999jqglPXWxy3SsUfdGC0a9DSN9yW-H8PeDjbmg8FOZ1-2Cd37fIuGOWS_CwV-sGEc9MvqmdMh2VfH9bT6dnW5WX-qb75cf15f3NSGcZFrKa2xYARuO91LSwVA64jU2HHNLBaOttIxTUnLedd1TS87Y41oZePK7DE9rT4svrtp_D7blNXgk7Eh6GjHOSnJhSCy4ayQb_8i78Z5iiW5AwREYgYFerdAWx2s8tGNedLmYKkuBAXZUgBZqLN_UGX0dvCmlMz5cv-HAC8CM40pTdap3eRLWR8UBnXor1r6q-DnWUrVFs2bY75zN9j-t-JXQwvw_gjoZHRwk47Gp0eOEUIxJoUjC5dKKG7t9Pjx_7_-Azd8usM</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Sager, Sait</creator><creator>Ergül, Nurhan</creator><creator>Ciftci, Hediye</creator><creator>Cetin, Güven</creator><creator>Güner, Sebnem İzmir</creator><creator>Cermik, Teyfik Fikret</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>The value of FDG PET/CT in the initial staging and bone marrow involvement of patients with multiple myeloma</title><author>Sager, Sait ; Ergül, Nurhan ; Ciftci, Hediye ; Cetin, Güven ; Güner, Sebnem İzmir ; Cermik, Teyfik Fikret</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-88ece0c719bad8e37009f28a1f6a4e17f398f4a32966bbb5d8bcec7985f985d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - diagnostic imaging</topic><topic>Bone Marrow - pathology</topic><topic>Care and treatment</topic><topic>Female</topic><topic>Fluorine compounds</topic><topic>Fluorodeoxyglucose F18</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Imaging</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Multiple myeloma</topic><topic>Multiple Myeloma - diagnostic imaging</topic><topic>Multiple Myeloma - pathology</topic><topic>Neoplasm Staging</topic><topic>Nuclear Medicine</topic><topic>Orthopedics</topic><topic>Osteoarticular system. Muscles</topic><topic>Pathology</topic><topic>PET imaging</topic><topic>Positron-Emission Tomography - methods</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Radiology</topic><topic>Radiopharmaceuticals</topic><topic>Reproducibility of Results</topic><topic>Scientific Article</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sager, Sait</creatorcontrib><creatorcontrib>Ergül, Nurhan</creatorcontrib><creatorcontrib>Ciftci, Hediye</creatorcontrib><creatorcontrib>Cetin, Güven</creatorcontrib><creatorcontrib>Güner, Sebnem İzmir</creatorcontrib><creatorcontrib>Cermik, Teyfik Fikret</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Skeletal radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sager, Sait</au><au>Ergül, Nurhan</au><au>Ciftci, Hediye</au><au>Cetin, Güven</au><au>Güner, Sebnem İzmir</au><au>Cermik, Teyfik Fikret</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The value of FDG PET/CT in the initial staging and bone marrow involvement of patients with multiple myeloma</atitle><jtitle>Skeletal radiology</jtitle><stitle>Skeletal Radiol</stitle><addtitle>Skeletal Radiol</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>40</volume><issue>7</issue><spage>843</spage><epage>847</epage><pages>843-847</pages><issn>0364-2348</issn><eissn>1432-2161</eissn><coden>SKRADI</coden><abstract>Objective
The aim of this study was to describe the role of positron emission tomography/computed tomography (PET/CT) with fluorine-18 fluorodeoxyglucose (FDG) in the detection of skeletal and visceral involvement in patients with MM (multiple myeloma) at the initial diagnosis and to evaluate the relation between maximum standardized uptake values (SUVmax) of FDG with bone marrow cellularity and plasma cell ratios.
Materials and methods
The study population consisted of 42 patients (15 F, 28 M; mean ± SD age; 47 ± 12 years). Thirty-two patients were referred for initial diagnosis and ten patients were referred for assessment of therapy response. PET/CT scan was obtained 60 min after the administration of 5.4 MBq/kg FDG. The SUVmax of FDG uptake was measured from the region of interest, which was placed at the site of most prominent lesion in bone marrow in PET/CT images.
Results
Thirty patients were positive (29 of 32 initially diagnosed, one of ten previously treated) and 12 patients were negative on PET/CT scan. Conventional radiological methods were negative in three of 30 FDG PET/CT-positive patients and these methods did not show any pathological finding in 12 FDG PET/CT-negative patients. The sensitivity of FDG PET in detecting bone marrow involvement at initial diagnosis was 90%. There was a significant correlation between SUVmax values and bone marrow biopsy cellularity and plasma cell ratios, (
r
= 0.54 and
r
= 0.74,
p
< 0.01).
Conclusions
The results of this study demonstrated that FDG-PET is a useful technique for the assessment of MM and the correlation between SUVmax and plasma cell ratios in bone marrow biopsy may avoid repeated bone marrow biopsies in the follow-up period.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21229354</pmid><doi>10.1007/s00256-010-1088-9</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Skeletal radiology, 2011-07, Vol.40 (7), p.843-847 |
| issn | 0364-2348 1432-2161 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Bone Marrow - diagnostic imaging Bone Marrow - pathology Care and treatment Female Fluorine compounds Fluorodeoxyglucose F18 Hematologic and hematopoietic diseases Humans Imaging Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Investigative techniques, diagnostic techniques (general aspects) Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical research Medical sciences Medicine Medicine & Public Health Medicine, Experimental Middle Aged Multiple myeloma Multiple Myeloma - diagnostic imaging Multiple Myeloma - pathology Neoplasm Staging Nuclear Medicine Orthopedics Osteoarticular system. Muscles Pathology PET imaging Positron-Emission Tomography - methods Radiodiagnosis. Nmr imagery. Nmr spectrometry Radiology Radiopharmaceuticals Reproducibility of Results Scientific Article Sensitivity and Specificity Tomography, X-Ray Computed - methods Young Adult |
| title | The value of FDG PET/CT in the initial staging and bone marrow involvement of patients with multiple myeloma |
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