Bone structural changes in osteoarthritis as a result of mechanoregulated bone adaptation: a modeling approach

Summary Objective There are strong indications that subchondral bone may play an important role in osteoarthritis (OA), making it an interesting target for medical therapies. The subchondral bone structure changes markedly during OA, and it has long been assumed that this occurs secondary to cartila...

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Veröffentlicht in:	Osteoarthritis and cartilage 2011-06, Vol.19 (6), p.676-682
Hauptverfasser:	Cox, L.G.E, van Rietbergen, B, van Donkelaar, C.C, Ito, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Algorithms Biomechanical Phenomena Bone and Bones - pathology Bone architecture Bone Remodeling - physiology Cartilage, Articular - pathology Computer Simulation Humans Mechanoregulation Osteoarthritis Osteoarthritis - pathology Remodeling Rheumatology
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