2-(2-Fluorobenzamido)benzoate ethyl ester (EFB-1) inhibits superoxide production by human neutrophils and attenuates hemorrhagic shock-induced organ dysfunction in rats

Neutrophil activation after trauma–hemorrhagic shock (T/H) has been implicated in the development of multiple organ dysfunction (MOD). In this study, we report that a small chemical compound, 2-(2-fluorobenzamido)benzoic acid ethyl ester (EFB-1), exhibited a potent inhibitory effect on the formyl-l-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Free radical biology & medicine 2011-06, Vol.50 (12), p.1737-1748
Hauptverfasser:	Yu, Huang-Ping, Hsieh, Pei-Wen, Chang, Yi-Ju, Chung, Pei-Jen, Kuo, Liang-Mou, Hwang, Tsong-Long
Format:	Artikel
Sprache:	eng
Schlagworte:	2-(2-Fluorobenzamido)benzoic acid ethyl ester 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors adenylate cyclase Adenylyl Cyclases - drug effects Adenylyl Cyclases - metabolism alanine transaminase Animals aspartate transaminase Benzamides - pharmacology Benzoates - pharmacology benzoic acid calcium cAMP-dependent protein kinase CD11b Antigen - drug effects CD11b Antigen - metabolism Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - drug effects Cyclic AMP-Dependent Protein Kinases - metabolism Free Radicals Humans intestines Intestines - drug effects Intestines - injuries Leukocyte Elastase - drug effects Leukocyte Elastase - metabolism liver Liver - drug effects Liver - injuries Lung Injury - etiology Lung Injury - prevention & control lungs Multiple organ dysfunction Multiple Organ Failure - etiology Multiple Organ Failure - prevention & control myeloperoxidase Neutrophil Activation - drug effects Neutrophils Neutrophils - drug effects Neutrophils - metabolism Phosphodiesterase protein phosphorylation Proto-Oncogene Proteins c-akt - drug effects Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Shock, Hemorrhagic - complications Shock, Hemorrhagic - metabolism Superoxide anion Superoxides - antagonists & inhibitors Trauma–hemorrhagic shock
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!