Biomarkers of oxidative damage in cigarette smokers: Which biomarkers might reflect acute versus chronic oxidative stress?
Cigarette smoking predisposes to the development of multiple diseases involving oxidative damage. We measured a range of oxidative damage biomarkers to understand which differ between smokers and nonsmokers and if the levels of these biomarkers change further during the act of smoking itself. Despit...
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| Veröffentlicht in: | Free radical biology & medicine 2011-06, Vol.50 (12), p.1787-1793 |
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| creator | Seet, Raymond C.S. Lee, Chung-Yung J. Loke, Wai Mun Huang, Shan Hong Huang, Huiwen Looi, Woan Foon Chew, Eng Soh Quek, Amy M.L. Lim, Erle C.H. Halliwell, Barry |
| description | Cigarette smoking predisposes to the development of multiple diseases involving oxidative damage. We measured a range of oxidative damage biomarkers to understand which differ between smokers and nonsmokers and if the levels of these biomarkers change further during the act of smoking itself. Despite overnight abstinence from smoking, smokers had higher levels of plasma total and esterified F2-isoprostanes, hydroxyeicosatetraenoic acid products (HETEs), F4-neuroprostanes, 7-ketocholesterol, and 24- and 27-hydroxycholesterol. Levels of urinary F2-isoprostanes, HETEs, and 8-hydroxy-2′-deoxyguanosine were also increased compared with age-matched nonsmokers. Several biomarkers (plasma free F2-isoprostanes, allantoin, and 7β-hydroxycholesterol and urinary F2-isoprostane metabolites) were not elevated. The smokers were then asked to smoke a cigarette; this acute smoking elevated plasma and urinary F2-isoprostanes, plasma allantoin, and certain cholesterol oxidation products compared to presmoking levels, but not plasma HETEs or urinary 8-hydroxy-2′-deoxyguanosine. Smokers showed differences in plasma fatty acid composition. Our findings confirm that certain oxidative damage biomarkers are elevated in smokers even after a period of abstinence from smoking, whereas these plus some others are elevated after acute smoking. Thus, different biomarkers do not measure identical aspects of oxidative stress. |
| doi_str_mv | 10.1016/j.freeradbiomed.2011.03.019 |
| format | Article |
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We measured a range of oxidative damage biomarkers to understand which differ between smokers and nonsmokers and if the levels of these biomarkers change further during the act of smoking itself. Despite overnight abstinence from smoking, smokers had higher levels of plasma total and esterified F2-isoprostanes, hydroxyeicosatetraenoic acid products (HETEs), F4-neuroprostanes, 7-ketocholesterol, and 24- and 27-hydroxycholesterol. Levels of urinary F2-isoprostanes, HETEs, and 8-hydroxy-2′-deoxyguanosine were also increased compared with age-matched nonsmokers. Several biomarkers (plasma free F2-isoprostanes, allantoin, and 7β-hydroxycholesterol and urinary F2-isoprostane metabolites) were not elevated. The smokers were then asked to smoke a cigarette; this acute smoking elevated plasma and urinary F2-isoprostanes, plasma allantoin, and certain cholesterol oxidation products compared to presmoking levels, but not plasma HETEs or urinary 8-hydroxy-2′-deoxyguanosine. Smokers showed differences in plasma fatty acid composition. Our findings confirm that certain oxidative damage biomarkers are elevated in smokers even after a period of abstinence from smoking, whereas these plus some others are elevated after acute smoking. Thus, different biomarkers do not measure identical aspects of oxidative stress.</description><identifier>ISSN: 0891-5849</identifier><identifier>EISSN: 1873-4596</identifier><identifier>DOI: 10.1016/j.freeradbiomed.2011.03.019</identifier><identifier>PMID: 21420490</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; allantoin ; Allantoin - blood ; biomarkers ; Biomarkers - blood ; Biomarkers - urine ; cholesterol ; Cholesterol oxidation products ; Cigarette smoking ; cigarettes ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - metabolism ; Deoxyguanosine - urine ; esterification ; F2-Isoprostanes - blood ; F2-Isoprostanes - metabolism ; F2-Isoprostanes - urine ; fatty acid composition ; Free Radicals ; Humans ; Hydroxycholesterols - blood ; Hydroxycholesterols - metabolism ; Hydroxyeicosatetraenoic acid products ; Hydroxyeicosatetraenoic Acids - blood ; Hydroxyeicosatetraenoic Acids - metabolism ; Hydroxyeicosatetraenoic Acids - urine ; Isoprostanes ; Ketocholesterols - blood ; Ketocholesterols - metabolism ; Male ; metabolites ; Middle Aged ; oxidation ; Oxidative Stress ; smoking (habit) ; Smoking - blood ; Smoking - metabolism ; Smoking - urine</subject><ispartof>Free radical biology & medicine, 2011-06, Vol.50 (12), p.1787-1793</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-ebd69beeaa476e64bb698762f1bff6ced589f32f9ac479e083cffdae9f5b2b3e3</citedby><cites>FETCH-LOGICAL-c439t-ebd69beeaa476e64bb698762f1bff6ced589f32f9ac479e083cffdae9f5b2b3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0891584911001766$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21420490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seet, Raymond C.S.</creatorcontrib><creatorcontrib>Lee, Chung-Yung J.</creatorcontrib><creatorcontrib>Loke, Wai Mun</creatorcontrib><creatorcontrib>Huang, Shan Hong</creatorcontrib><creatorcontrib>Huang, Huiwen</creatorcontrib><creatorcontrib>Looi, Woan Foon</creatorcontrib><creatorcontrib>Chew, Eng Soh</creatorcontrib><creatorcontrib>Quek, Amy M.L.</creatorcontrib><creatorcontrib>Lim, Erle C.H.</creatorcontrib><creatorcontrib>Halliwell, Barry</creatorcontrib><title>Biomarkers of oxidative damage in cigarette smokers: Which biomarkers might reflect acute versus chronic oxidative stress?</title><title>Free radical biology & medicine</title><addtitle>Free Radic Biol Med</addtitle><description>Cigarette smoking predisposes to the development of multiple diseases involving oxidative damage. We measured a range of oxidative damage biomarkers to understand which differ between smokers and nonsmokers and if the levels of these biomarkers change further during the act of smoking itself. Despite overnight abstinence from smoking, smokers had higher levels of plasma total and esterified F2-isoprostanes, hydroxyeicosatetraenoic acid products (HETEs), F4-neuroprostanes, 7-ketocholesterol, and 24- and 27-hydroxycholesterol. Levels of urinary F2-isoprostanes, HETEs, and 8-hydroxy-2′-deoxyguanosine were also increased compared with age-matched nonsmokers. Several biomarkers (plasma free F2-isoprostanes, allantoin, and 7β-hydroxycholesterol and urinary F2-isoprostane metabolites) were not elevated. The smokers were then asked to smoke a cigarette; this acute smoking elevated plasma and urinary F2-isoprostanes, plasma allantoin, and certain cholesterol oxidation products compared to presmoking levels, but not plasma HETEs or urinary 8-hydroxy-2′-deoxyguanosine. Smokers showed differences in plasma fatty acid composition. Our findings confirm that certain oxidative damage biomarkers are elevated in smokers even after a period of abstinence from smoking, whereas these plus some others are elevated after acute smoking. Thus, different biomarkers do not measure identical aspects of oxidative stress.</description><subject>Adult</subject><subject>Aged</subject><subject>allantoin</subject><subject>Allantoin - blood</subject><subject>biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>cholesterol</subject><subject>Cholesterol oxidation products</subject><subject>Cigarette smoking</subject><subject>cigarettes</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - metabolism</subject><subject>Deoxyguanosine - urine</subject><subject>esterification</subject><subject>F2-Isoprostanes - blood</subject><subject>F2-Isoprostanes - metabolism</subject><subject>F2-Isoprostanes - urine</subject><subject>fatty acid composition</subject><subject>Free Radicals</subject><subject>Humans</subject><subject>Hydroxycholesterols - blood</subject><subject>Hydroxycholesterols - metabolism</subject><subject>Hydroxyeicosatetraenoic acid products</subject><subject>Hydroxyeicosatetraenoic Acids - blood</subject><subject>Hydroxyeicosatetraenoic Acids - metabolism</subject><subject>Hydroxyeicosatetraenoic Acids - urine</subject><subject>Isoprostanes</subject><subject>Ketocholesterols - blood</subject><subject>Ketocholesterols - metabolism</subject><subject>Male</subject><subject>metabolites</subject><subject>Middle Aged</subject><subject>oxidation</subject><subject>Oxidative Stress</subject><subject>smoking (habit)</subject><subject>Smoking - blood</subject><subject>Smoking - metabolism</subject><subject>Smoking - urine</subject><issn>0891-5849</issn><issn>1873-4596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EokvhK4AlDnBJGMeOE8MBQVX-SJU4QMXRsp3xrpfNutjJCvj0OGwr4II4-TC_98bzHiGPGdQMmHy2rX1CTGawIY441A0wVgOvgalbZMX6jleiVfI2WUGvWNX2Qp2QezlvAUC0vL9LThomGhAKVuTH62Ji0hdMmUZP47cwmCkckA5mNGukYU9dWJuE04Q0j3EBn9PPm-A21P6WjmG9mWhCv0M3UePmQh_KYM7UbVLcB_eHdZ4S5vzyPrnjzS7jg-v3lFy-Of909q66-PD2_dmri8oJrqYK7SCVRTRGdBKlsFaqvpONZ9Z76XBoe-V545VxolMIPXfeDwaVb21jOfJT8uToe5Xi1xnzpMeQHe52Zo9xzrqXnehZA6qQT_9JMlkWSwG_0BdH1KWYczlcX6VQ0viuGeilJr3Vf9Wkl5o0cF1qKuqH14tmu8xutDe9FODREfAmarNOIevLj8WhBWBcCrVYnB8JLNEdAiadXcB9ySOk0oEeYvivr_wEp8C4eA</recordid><startdate>20110615</startdate><enddate>20110615</enddate><creator>Seet, Raymond C.S.</creator><creator>Lee, Chung-Yung J.</creator><creator>Loke, Wai Mun</creator><creator>Huang, Shan Hong</creator><creator>Huang, Huiwen</creator><creator>Looi, Woan Foon</creator><creator>Chew, Eng Soh</creator><creator>Quek, Amy M.L.</creator><creator>Lim, Erle C.H.</creator><creator>Halliwell, Barry</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20110615</creationdate><title>Biomarkers of oxidative damage in cigarette smokers: Which biomarkers might reflect acute versus chronic oxidative stress?</title><author>Seet, Raymond C.S. ; Lee, Chung-Yung J. ; Loke, Wai Mun ; Huang, Shan Hong ; Huang, Huiwen ; Looi, Woan Foon ; Chew, Eng Soh ; Quek, Amy M.L. ; Lim, Erle C.H. ; Halliwell, Barry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-ebd69beeaa476e64bb698762f1bff6ced589f32f9ac479e083cffdae9f5b2b3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>allantoin</topic><topic>Allantoin - blood</topic><topic>biomarkers</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>cholesterol</topic><topic>Cholesterol oxidation products</topic><topic>Cigarette smoking</topic><topic>cigarettes</topic><topic>Deoxyguanosine - analogs & derivatives</topic><topic>Deoxyguanosine - metabolism</topic><topic>Deoxyguanosine - urine</topic><topic>esterification</topic><topic>F2-Isoprostanes - blood</topic><topic>F2-Isoprostanes - metabolism</topic><topic>F2-Isoprostanes - urine</topic><topic>fatty acid composition</topic><topic>Free Radicals</topic><topic>Humans</topic><topic>Hydroxycholesterols - blood</topic><topic>Hydroxycholesterols - metabolism</topic><topic>Hydroxyeicosatetraenoic acid products</topic><topic>Hydroxyeicosatetraenoic Acids - blood</topic><topic>Hydroxyeicosatetraenoic Acids - metabolism</topic><topic>Hydroxyeicosatetraenoic Acids - urine</topic><topic>Isoprostanes</topic><topic>Ketocholesterols - blood</topic><topic>Ketocholesterols - metabolism</topic><topic>Male</topic><topic>metabolites</topic><topic>Middle Aged</topic><topic>oxidation</topic><topic>Oxidative Stress</topic><topic>smoking (habit)</topic><topic>Smoking - blood</topic><topic>Smoking - metabolism</topic><topic>Smoking - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seet, Raymond C.S.</creatorcontrib><creatorcontrib>Lee, Chung-Yung J.</creatorcontrib><creatorcontrib>Loke, Wai Mun</creatorcontrib><creatorcontrib>Huang, Shan Hong</creatorcontrib><creatorcontrib>Huang, Huiwen</creatorcontrib><creatorcontrib>Looi, Woan Foon</creatorcontrib><creatorcontrib>Chew, Eng Soh</creatorcontrib><creatorcontrib>Quek, Amy M.L.</creatorcontrib><creatorcontrib>Lim, Erle C.H.</creatorcontrib><creatorcontrib>Halliwell, Barry</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Free radical biology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seet, Raymond C.S.</au><au>Lee, Chung-Yung J.</au><au>Loke, Wai Mun</au><au>Huang, Shan Hong</au><au>Huang, Huiwen</au><au>Looi, Woan Foon</au><au>Chew, Eng Soh</au><au>Quek, Amy M.L.</au><au>Lim, Erle C.H.</au><au>Halliwell, Barry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers of oxidative damage in cigarette smokers: Which biomarkers might reflect acute versus chronic oxidative stress?</atitle><jtitle>Free radical biology & medicine</jtitle><addtitle>Free Radic Biol Med</addtitle><date>2011-06-15</date><risdate>2011</risdate><volume>50</volume><issue>12</issue><spage>1787</spage><epage>1793</epage><pages>1787-1793</pages><issn>0891-5849</issn><eissn>1873-4596</eissn><abstract>Cigarette smoking predisposes to the development of multiple diseases involving oxidative damage. We measured a range of oxidative damage biomarkers to understand which differ between smokers and nonsmokers and if the levels of these biomarkers change further during the act of smoking itself. Despite overnight abstinence from smoking, smokers had higher levels of plasma total and esterified F2-isoprostanes, hydroxyeicosatetraenoic acid products (HETEs), F4-neuroprostanes, 7-ketocholesterol, and 24- and 27-hydroxycholesterol. Levels of urinary F2-isoprostanes, HETEs, and 8-hydroxy-2′-deoxyguanosine were also increased compared with age-matched nonsmokers. Several biomarkers (plasma free F2-isoprostanes, allantoin, and 7β-hydroxycholesterol and urinary F2-isoprostane metabolites) were not elevated. The smokers were then asked to smoke a cigarette; this acute smoking elevated plasma and urinary F2-isoprostanes, plasma allantoin, and certain cholesterol oxidation products compared to presmoking levels, but not plasma HETEs or urinary 8-hydroxy-2′-deoxyguanosine. Smokers showed differences in plasma fatty acid composition. Our findings confirm that certain oxidative damage biomarkers are elevated in smokers even after a period of abstinence from smoking, whereas these plus some others are elevated after acute smoking. Thus, different biomarkers do not measure identical aspects of oxidative stress.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21420490</pmid><doi>10.1016/j.freeradbiomed.2011.03.019</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| subjects | Adult Aged allantoin Allantoin - blood biomarkers Biomarkers - blood Biomarkers - urine cholesterol Cholesterol oxidation products Cigarette smoking cigarettes Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Deoxyguanosine - urine esterification F2-Isoprostanes - blood F2-Isoprostanes - metabolism F2-Isoprostanes - urine fatty acid composition Free Radicals Humans Hydroxycholesterols - blood Hydroxycholesterols - metabolism Hydroxyeicosatetraenoic acid products Hydroxyeicosatetraenoic Acids - blood Hydroxyeicosatetraenoic Acids - metabolism Hydroxyeicosatetraenoic Acids - urine Isoprostanes Ketocholesterols - blood Ketocholesterols - metabolism Male metabolites Middle Aged oxidation Oxidative Stress smoking (habit) Smoking - blood Smoking - metabolism Smoking - urine |
| title | Biomarkers of oxidative damage in cigarette smokers: Which biomarkers might reflect acute versus chronic oxidative stress? |
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