Troponin I and C-Reactive Protein Are Commonly Detected in Patients with Breast Cancer Treated with Dose-Dense Chemotherapy Incorporating Trastuzumab and Lapatinib

There are no validated methods of early detection of cardiotoxicity from trastuzumab (T) following anthracycline-based chemotherapy. Currently changes in left ventricular ejection fraction (LVEF) are assessed but this approach has limited sensitivity and specificity. Within a prospective feasibility...

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Veröffentlicht in:	Clinical cancer research 2011-05, Vol.17 (10), p.3490-3499
Hauptverfasser:	MORRIS, Patrick G, CHEN, Carol, PATIL, Sujata, DICKLER, Maura, MCARTHUR, Heather L, WINER, Eric, NORTON, Larry, HUDIS, Clifford A, DANG, Chau T, STEINGART, Richard, FLEISHER, Martin, LIN, Nancy, MOY, Beverly, COME, Steven, SUGARMAN, Steven, ABBRUZZI, Alyson, LEHMAN, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal, Humanized Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Biological and medical sciences Biomarkers, Pharmacological - metabolism Biomarkers, Tumor - metabolism Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - physiopathology C-Reactive Protein - metabolism Carcinoma - drug therapy Carcinoma - metabolism Carcinoma - physiopathology Dose-Response Relationship, Drug Feasibility Studies Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Middle Aged Pharmacology. Drug treatments Quinazolines - administration & dosage Quinazolines - adverse effects Stroke Volume - drug effects Trastuzumab Troponin I - metabolism Tumors
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