Knockdown of FLOT1 Impairs Cell Proliferation and Tumorigenicity in Breast Cancer through Upregulation of FOXO3a

Lipid rafts, specialized domains in cell membranes, function as physical platforms for various molecules to coordinate a variety of signal transduction processes. Flotinllin-1 (FLOT1), a marker of lipid rafts, is involved in the progression of cancer, but the precise mechanism remains unclear. The a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2011-05, Vol.17 (10), p.3089-3099
Hauptverfasser:	Lin, Chuyong, Wu, Zhiqiang, Lin, Xi, Yu, Chunping, Shi, Tingting, Zeng, Yong, Wang, Xi, Li, Jun, Song, Libing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma - genetics Carcinoma - pathology Cell Line, Tumor Cell Proliferation - drug effects Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Female Forkhead Box Protein O3 Forkhead Transcription Factors - genetics Gene Expression Regulation, Neoplastic - drug effects Gene Knockdown Techniques Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Membrane Proteins - antagonists & inhibitors Membrane Proteins - genetics Mice Mice, Inbred BALB C Mice, Nude Pharmacology. Drug treatments RNA, Small Interfering - pharmacology Tumors Up-Regulation - drug effects Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!