General Movements in Full-Term Infants with Perinatal Asphyxia Are Related to Basal Ganglia and Thalamic Lesions
Objective To correlate the site and severity of brain lesions seen on magnetic resonance imaging (MRI) with the quality of general movements in term infants with hypoxic-ischemic encephalopathy (HIE) and compare the prognostic value of general movements and MRI for motor outcome. Study design Early...
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| Veröffentlicht in: | The Journal of pediatrics 2011-06, Vol.158 (6), p.904-911 |
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| creator | Ferrari, Fabrizio, MD Todeschini, Alessandra, MD Guidotti, Isotta, MD Martinez-Biarge, Miriam, MD Roversi, Maria Federica, MD Berardi, Alberto, MD Ranzi, Andrea, PhD Cowan, Frances M., MRCPCH, PhD Rutherford, Mary A., MD, FRCR |
| description | Objective To correlate the site and severity of brain lesions seen on magnetic resonance imaging (MRI) with the quality of general movements in term infants with hypoxic-ischemic encephalopathy (HIE) and compare the prognostic value of general movements and MRI for motor outcome. Study design Early brain MRI scans in 34 term infants with HIE not treated with hypothermia were reviewed and scored for site of injury and lesion pattern by an experienced neuroradiologist. General movement quality and trajectories at 1 and 3 postnatal months were evaluated. Motor outcome was assessed at 24 months. Results MRI scores for the basal ganglia and thalami, posterior limb of the internal capsule, white matter, and cortex and lesion patterns were correlated with 1-month and 3-month general movements and general movement trajectories; central gray matter scores were correlated most strongly with cramped-synchronized general movements and abnormal motor outcome. MRI scores were 100% sensitive and 72.2% specific for motor outcome, and cramped-synchronized general movements were 100% specific and 68.7% sensitive for motor outcome. Conclusions In term infants with HIE, the site and severity of brain lesions seen on early MRI are highly correlated with general movements. Central gray matter damage leads to cramped-synchronized general movements and poor motor outcome. Early MRI scans and general movements are complementary tools for predicting motor outcome. |
| doi_str_mv | 10.1016/j.jpeds.2010.11.037 |
| format | Article |
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Study design Early brain MRI scans in 34 term infants with HIE not treated with hypothermia were reviewed and scored for site of injury and lesion pattern by an experienced neuroradiologist. General movement quality and trajectories at 1 and 3 postnatal months were evaluated. Motor outcome was assessed at 24 months. Results MRI scores for the basal ganglia and thalami, posterior limb of the internal capsule, white matter, and cortex and lesion patterns were correlated with 1-month and 3-month general movements and general movement trajectories; central gray matter scores were correlated most strongly with cramped-synchronized general movements and abnormal motor outcome. MRI scores were 100% sensitive and 72.2% specific for motor outcome, and cramped-synchronized general movements were 100% specific and 68.7% sensitive for motor outcome. Conclusions In term infants with HIE, the site and severity of brain lesions seen on early MRI are highly correlated with general movements. Central gray matter damage leads to cramped-synchronized general movements and poor motor outcome. Early MRI scans and general movements are complementary tools for predicting motor outcome.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2010.11.037</identifier><identifier>PMID: 21232764</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>Maryland Heights, MO: Mosby, Inc</publisher><subject>asphyxia ; Asphyxia - pathology ; Basal Ganglia - injuries ; Basal Ganglia - pathology ; Biological and medical sciences ; brain ; Cerebral Palsy - pathology ; cortex ; encephalopathy ; Female ; ganglia ; General aspects ; Gestational Age ; Humans ; hypothermia ; Infant, Newborn ; infants ; magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Motor Skills ; Movement ; Neurology - methods ; Pediatrics ; prediction ; Prognosis ; Thalamus - injuries ; Thalamus - pathology</subject><ispartof>The Journal of pediatrics, 2011-06, Vol.158 (6), p.904-911</ispartof><rights>Mosby, Inc.</rights><rights>2011 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-f6dbb3dfd15d00f65d1ea521df36f5a3cb481b8c42f1cd2b322ef438454fb3313</citedby><cites>FETCH-LOGICAL-c467t-f6dbb3dfd15d00f65d1ea521df36f5a3cb481b8c42f1cd2b322ef438454fb3313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2010.11.037$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24220286$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21232764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferrari, Fabrizio, MD</creatorcontrib><creatorcontrib>Todeschini, Alessandra, MD</creatorcontrib><creatorcontrib>Guidotti, Isotta, MD</creatorcontrib><creatorcontrib>Martinez-Biarge, Miriam, MD</creatorcontrib><creatorcontrib>Roversi, Maria Federica, MD</creatorcontrib><creatorcontrib>Berardi, Alberto, MD</creatorcontrib><creatorcontrib>Ranzi, Andrea, PhD</creatorcontrib><creatorcontrib>Cowan, Frances M., MRCPCH, PhD</creatorcontrib><creatorcontrib>Rutherford, Mary A., MD, FRCR</creatorcontrib><title>General Movements in Full-Term Infants with Perinatal Asphyxia Are Related to Basal Ganglia and Thalamic Lesions</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective To correlate the site and severity of brain lesions seen on magnetic resonance imaging (MRI) with the quality of general movements in term infants with hypoxic-ischemic encephalopathy (HIE) and compare the prognostic value of general movements and MRI for motor outcome. Study design Early brain MRI scans in 34 term infants with HIE not treated with hypothermia were reviewed and scored for site of injury and lesion pattern by an experienced neuroradiologist. General movement quality and trajectories at 1 and 3 postnatal months were evaluated. Motor outcome was assessed at 24 months. Results MRI scores for the basal ganglia and thalami, posterior limb of the internal capsule, white matter, and cortex and lesion patterns were correlated with 1-month and 3-month general movements and general movement trajectories; central gray matter scores were correlated most strongly with cramped-synchronized general movements and abnormal motor outcome. MRI scores were 100% sensitive and 72.2% specific for motor outcome, and cramped-synchronized general movements were 100% specific and 68.7% sensitive for motor outcome. Conclusions In term infants with HIE, the site and severity of brain lesions seen on early MRI are highly correlated with general movements. Central gray matter damage leads to cramped-synchronized general movements and poor motor outcome. Early MRI scans and general movements are complementary tools for predicting motor outcome.</description><subject>asphyxia</subject><subject>Asphyxia - pathology</subject><subject>Basal Ganglia - injuries</subject><subject>Basal Ganglia - pathology</subject><subject>Biological and medical sciences</subject><subject>brain</subject><subject>Cerebral Palsy - pathology</subject><subject>cortex</subject><subject>encephalopathy</subject><subject>Female</subject><subject>ganglia</subject><subject>General aspects</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>hypothermia</subject><subject>Infant, Newborn</subject><subject>infants</subject><subject>magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Skills</subject><subject>Movement</subject><subject>Neurology - methods</subject><subject>Pediatrics</subject><subject>prediction</subject><subject>Prognosis</subject><subject>Thalamus - injuries</subject><subject>Thalamus - pathology</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEotvCL0ACXxCnLP7Ih3ug0lLRpdIiEN2eLccedx0cJ9hJy_57HHYBiQsnSzPP-3r0zmTZC4KXBJPqbbtsB9BxSfFcIUvM6kfZguDzOq84Y4-zBcaU5qyoq5PsNMYWY3xeYPw0O6GEMlpXxSIb1uAhSIc-9ffQgR8jsh5dTc7lWwgduvZGzsUHO-7QFwjWyzHRqzjs9j-sRKsA6Cs4OYJGY4_ey5i6a-nvXGpKr9F2J53srEIbiLb38Vn2xEgX4fnxPcturz5sLz_mm8_r68vVJldFVY-5qXTTMG00KTXGpio1AVlSog2rTCmZagpOGq4KaojStGGUgikYL8rCNIwRdpa9OfgOof8-QRxFZ6MC56SHfoqCVzWjJeE8kexAqtDHGMCIIdhOhr0gWMxJi1b8SlrMSQtCREo6qV4e_aemA_1H8zvaBLw-AjIq6UyQXtn4lysoxZRXiXt14IzshbwLibm9ST-VaV28ppQm4t2BgJTXvYUgorLgFWgbQI1C9_Y_o178o1fOepuG-gZ7iG0_BZ9WIYiIVGBxM5_NfDUEJxPMS_YT3mu7SQ</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Ferrari, Fabrizio, MD</creator><creator>Todeschini, Alessandra, MD</creator><creator>Guidotti, Isotta, MD</creator><creator>Martinez-Biarge, Miriam, MD</creator><creator>Roversi, Maria Federica, MD</creator><creator>Berardi, Alberto, MD</creator><creator>Ranzi, Andrea, PhD</creator><creator>Cowan, Frances M., MRCPCH, PhD</creator><creator>Rutherford, Mary A., MD, FRCR</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>General Movements in Full-Term Infants with Perinatal Asphyxia Are Related to Basal Ganglia and Thalamic Lesions</title><author>Ferrari, Fabrizio, MD ; Todeschini, Alessandra, MD ; Guidotti, Isotta, MD ; Martinez-Biarge, Miriam, MD ; Roversi, Maria Federica, MD ; Berardi, Alberto, MD ; Ranzi, Andrea, PhD ; Cowan, Frances M., MRCPCH, PhD ; Rutherford, Mary A., MD, FRCR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-f6dbb3dfd15d00f65d1ea521df36f5a3cb481b8c42f1cd2b322ef438454fb3313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>asphyxia</topic><topic>Asphyxia - pathology</topic><topic>Basal Ganglia - injuries</topic><topic>Basal Ganglia - pathology</topic><topic>Biological and medical sciences</topic><topic>brain</topic><topic>Cerebral Palsy - pathology</topic><topic>cortex</topic><topic>encephalopathy</topic><topic>Female</topic><topic>ganglia</topic><topic>General aspects</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>hypothermia</topic><topic>Infant, Newborn</topic><topic>infants</topic><topic>magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Skills</topic><topic>Movement</topic><topic>Neurology - methods</topic><topic>Pediatrics</topic><topic>prediction</topic><topic>Prognosis</topic><topic>Thalamus - injuries</topic><topic>Thalamus - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferrari, Fabrizio, MD</creatorcontrib><creatorcontrib>Todeschini, Alessandra, MD</creatorcontrib><creatorcontrib>Guidotti, Isotta, MD</creatorcontrib><creatorcontrib>Martinez-Biarge, Miriam, MD</creatorcontrib><creatorcontrib>Roversi, Maria Federica, MD</creatorcontrib><creatorcontrib>Berardi, Alberto, MD</creatorcontrib><creatorcontrib>Ranzi, Andrea, PhD</creatorcontrib><creatorcontrib>Cowan, Frances M., MRCPCH, PhD</creatorcontrib><creatorcontrib>Rutherford, Mary A., MD, FRCR</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferrari, Fabrizio, MD</au><au>Todeschini, Alessandra, MD</au><au>Guidotti, Isotta, MD</au><au>Martinez-Biarge, Miriam, MD</au><au>Roversi, Maria Federica, MD</au><au>Berardi, Alberto, MD</au><au>Ranzi, Andrea, PhD</au><au>Cowan, Frances M., MRCPCH, PhD</au><au>Rutherford, Mary A., MD, FRCR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>General Movements in Full-Term Infants with Perinatal Asphyxia Are Related to Basal Ganglia and Thalamic Lesions</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>158</volume><issue>6</issue><spage>904</spage><epage>911</epage><pages>904-911</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Objective To correlate the site and severity of brain lesions seen on magnetic resonance imaging (MRI) with the quality of general movements in term infants with hypoxic-ischemic encephalopathy (HIE) and compare the prognostic value of general movements and MRI for motor outcome. Study design Early brain MRI scans in 34 term infants with HIE not treated with hypothermia were reviewed and scored for site of injury and lesion pattern by an experienced neuroradiologist. General movement quality and trajectories at 1 and 3 postnatal months were evaluated. Motor outcome was assessed at 24 months. Results MRI scores for the basal ganglia and thalami, posterior limb of the internal capsule, white matter, and cortex and lesion patterns were correlated with 1-month and 3-month general movements and general movement trajectories; central gray matter scores were correlated most strongly with cramped-synchronized general movements and abnormal motor outcome. MRI scores were 100% sensitive and 72.2% specific for motor outcome, and cramped-synchronized general movements were 100% specific and 68.7% sensitive for motor outcome. Conclusions In term infants with HIE, the site and severity of brain lesions seen on early MRI are highly correlated with general movements. Central gray matter damage leads to cramped-synchronized general movements and poor motor outcome. Early MRI scans and general movements are complementary tools for predicting motor outcome.</abstract><cop>Maryland Heights, MO</cop><pub>Mosby, Inc</pub><pmid>21232764</pmid><doi>10.1016/j.jpeds.2010.11.037</doi><tpages>8</tpages></addata></record> |
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| subjects | asphyxia Asphyxia - pathology Basal Ganglia - injuries Basal Ganglia - pathology Biological and medical sciences brain Cerebral Palsy - pathology cortex encephalopathy Female ganglia General aspects Gestational Age Humans hypothermia Infant, Newborn infants magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical sciences Motor Skills Movement Neurology - methods Pediatrics prediction Prognosis Thalamus - injuries Thalamus - pathology |
| title | General Movements in Full-Term Infants with Perinatal Asphyxia Are Related to Basal Ganglia and Thalamic Lesions |
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