The effects of lipoic acid and α-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial

Abstract Antioxidants probably play an important role in the etiology of type 2 diabetes (DM2). This study evaluated the effects of supplementation with lipoic acid (LA) and α-tocopherol on the lipid profile and insulin sensitivity of DM2 patients. A randomized, double-blind, placebo-controlled tria...

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Veröffentlicht in:Diabetes research and clinical practice 2011-05, Vol.92 (2), p.253-260
Hauptverfasser: de Oliveira, Andreia Madruga, Rondó, Patrícia Helen Carvalho, Luzia, Liania Alves, D’Abronzo, Francisco Homero, Illison, Vanessa Kristine
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container_end_page 260
container_issue 2
container_start_page 253
container_title Diabetes research and clinical practice
container_volume 92
creator de Oliveira, Andreia Madruga
Rondó, Patrícia Helen Carvalho
Luzia, Liania Alves
D’Abronzo, Francisco Homero
Illison, Vanessa Kristine
description Abstract Antioxidants probably play an important role in the etiology of type 2 diabetes (DM2). This study evaluated the effects of supplementation with lipoic acid (LA) and α-tocopherol on the lipid profile and insulin sensitivity of DM2 patients. A randomized, double-blind, placebo-controlled trial involving 102 DM2 patients divided into four groups to receive daily supplementation for 4 months with: 600 mg LA ( n = 26); 800 mg α-tocopherol ( n = 25); 800 mg α-tocopherol + 600 mg LA ( n = 25); placebo ( n = 26). Plasma α-tocopherol, lipid profile, glucose, insulin, and the HOMA index were determined before and after supplementation. Differences within and between groups were compared by ANOVA using Bonferroni correction. Student's t -test was used to compare means of two independent variables. The vitamin E/total cholesterol ratio improved significantly in patients supplemented with vitamin E + LA and vitamin E alone ( p ≤ 0.001). There were improvements of the lipid fractions in the groups receiving LA and vitamin E alone or in combination, and on the HOMA index in the LA group, but not significant. The results suggest that LA and vitamin E supplementation alone or in combination did not affect the lipid profile or insulin sensitivity of DM2 patients.
doi_str_mv 10.1016/j.diabres.2011.02.010
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This study evaluated the effects of supplementation with lipoic acid (LA) and α-tocopherol on the lipid profile and insulin sensitivity of DM2 patients. A randomized, double-blind, placebo-controlled trial involving 102 DM2 patients divided into four groups to receive daily supplementation for 4 months with: 600 mg LA ( n = 26); 800 mg α-tocopherol ( n = 25); 800 mg α-tocopherol + 600 mg LA ( n = 25); placebo ( n = 26). Plasma α-tocopherol, lipid profile, glucose, insulin, and the HOMA index were determined before and after supplementation. Differences within and between groups were compared by ANOVA using Bonferroni correction. Student's t -test was used to compare means of two independent variables. The vitamin E/total cholesterol ratio improved significantly in patients supplemented with vitamin E + LA and vitamin E alone ( p ≤ 0.001). There were improvements of the lipid fractions in the groups receiving LA and vitamin E alone or in combination, and on the HOMA index in the LA group, but not significant. 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subjects Adult
Aged
alpha-Tocopherol - therapeutic use
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Dietary Supplements
Double-Blind Method
Endocrinology & Metabolism
Female
Humans
Insulin - blood
Insulin resistance
Lipids - blood
Lipoic acid
Male
Metabolic syndrome
Middle Aged
Thioctic Acid - therapeutic use
Type 2 diabetes mellitus
Vitamin E
title The effects of lipoic acid and α-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial
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