IL-1beta in the trigeminal subnucleus caudalis contributes to extra-territorial allodynia/hyperalgesia following a trigeminal nerve injury

Abstract It has been reported that the whisker pad (WP) area, which is innervated by the second branch of the trigeminal nerve, shows allodynia/hyperalgesia following transection of the mental nerve (MN: the third branch of the trigeminal nerve). However, the mechanisms of this extra-territorial pai...

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Veröffentlicht in:	European journal of pain 2011-05, Vol.15 (5), p.467.e1-467.e14
Hauptverfasser:	Takahashi, Kouji, Watanabe, Mineo, Suekawa, Yohei, Ito, Goshi, Inubushi, Toshihiro, Hirose, Naoto, Murasaki, Kyoko, Hiyama, Shinji, Uchida, Takashi, Tanne, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Allodynia/hyperalgesia Anesthesia & Perioperative Care Animals Antirheumatic Agents - pharmacology Astrocytes - metabolism Astrocytes - pathology Disease Models, Animal Dizocilpine Maleate - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fos Hyperalgesia - drug therapy Hyperalgesia - metabolism Hyperalgesia - pathology Injections, Spinal Interleukin 1 Receptor Antagonist Protein - pharmacology Interleukin-1beta Interleukin-1beta - metabolism Mandible - innervation Mental nerve Microglia - metabolism Microglia - pathology Nerve injury Pain Medicine Rats Trigeminal Caudal Nucleus - metabolism Trigeminal Caudal Nucleus - pathology Trigeminal Nerve Injuries Up-Regulation - physiology Vibrissae - innervation
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