Local application of VEGF compensates callus deficiency after acute soft tissue trauma-results using a limb-shortening distraction procedure in rabbit tibia

Acute soft tissue trauma influences callus formation and fracture healing. Several studies showed a relationship between angiogenesis and bone formation during distraction osteogenesis. The purpose of this study was to investigate the influence of controlled release of vascular endothelial growth fa...

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Veröffentlicht in:	Journal of orthopaedic research 2011-07, Vol.29 (7), p.1093-1098
Hauptverfasser:	Ochman, Sabine, Frey, Sönke, Raschke, Michael J., Deventer, Jehan N., Meffert, Rainer H.
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Biomechanical Phenomena - drug effects Biomechanical Phenomena - physiology Bony Callus - drug effects Bony Callus - physiology distraction osteogenesis fracture healing Fracture Healing - drug effects Fracture Healing - physiology Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology ossification Osteogenesis, Distraction Rabbits Soft Tissue Injuries - drug therapy Soft Tissue Injuries - physiopathology Tibia - blood supply Tibia - injuries Tibia - surgery Tibial Fractures - drug therapy Tibial Fractures - physiopathology Torsion, Mechanical Vascular Endothelial Growth Factor A - pharmacology VEGF
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