Association of Serum Cytokine Levels With Treatment Response to Pegylated Interferon and Ribavirin Therapy in Genotype 1 Chronic Hepatitis C Patients

Background. We sought to clarify the associations among serum cytokines, amino acid substitutions in the interferon sensitivity-determining region (ISDR) and core region, and treatment outcome of pegylated interferon and ribavirin therapy in genotype 1 hepatitis C virus (HCV)-infected patients. Meth...

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Veröffentlicht in:	The Journal of infectious diseases 2011-04, Vol.203 (8), p.1087-1095
Hauptverfasser:	Yoneda, Suguru, Umemura, Takeji, Katsuyama, Yoshihiko, Kamijo, Atsushi, Joshita, Satoru, Komatsu, Michiharu, Ichijo, Tetsuya, Matsumoto, Akihiro, Yoshizawa, Kaname, Ota, Masao, Tanaka, Eiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Antiviral Agents - administration & dosage Antiviral Agents - therapeutic use Antivirals Biological and medical sciences Biomarkers Chronic hepatitis Cytokines Cytokines - blood Fundamental and applied biological sciences. Psychology Genotypes Health outcomes Hepatitis Hepatitis C Antigens - blood Hepatitis C virus Hepatitis C, Chronic - drug therapy Human viral diseases Humans Infections Infectious diseases Interferon-alpha - administration & dosage Interferon-alpha - therapeutic use Interferons Medical sciences Microbiology Polyethylene Glycols - administration & dosage Polyethylene Glycols - therapeutic use Recombinant Proteins Ribavirin - administration & dosage Ribavirin - therapeutic use Sensitivity and Specificity Viral Core Proteins - blood Viral diseases Viral hepatitis Virology Viruses
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