Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product

Two indole alkaloids, phidianidines A (1) and B (2), exhibiting an uncommon 1,2,4-oxadiazole ring linked to the indole system, have been isolated from the marine opisthobranch mollusk Phidiana militaris. The structures of the two metabolites have been elucidated by spectroscopic techniques. Phidiani...

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Veröffentlicht in:	Organic letters 2011-05, Vol.13 (10), p.2516-2519
Hauptverfasser:	Carbone, Marianna, Li, Yan, Irace, Carlo, Mollo, Ernesto, Castelluccio, Francesco, Di Pascale, Antonio, Cimino, Guido, Santamaria, Rita, Guo, Yue-Wei, Gavagnin, Margherita
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Drug Screening Assays, Antitumor HeLa Cells Humans Indole Alkaloids - chemistry Indole Alkaloids - isolation & purification Indole Alkaloids - pharmacology Marine Biology Molecular Structure Mollusca - chemistry Oxadiazoles - chemistry Oxadiazoles - isolation & purification Oxadiazoles - pharmacology
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