Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product

Two indole alkaloids, phidianidines A (1) and B (2), exhibiting an uncommon 1,2,4-oxadiazole ring linked to the indole system, have been isolated from the marine opisthobranch mollusk Phidiana militaris. The structures of the two metabolites have been elucidated by spectroscopic techniques. Phidiani...

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Veröffentlicht in:	Organic letters 2011-05, Vol.13 (10), p.2516-2519
Hauptverfasser:	Carbone, Marianna, Li, Yan, Irace, Carlo, Mollo, Ernesto, Castelluccio, Francesco, Di Pascale, Antonio, Cimino, Guido, Santamaria, Rita, Guo, Yue-Wei, Gavagnin, Margherita
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Drug Screening Assays, Antitumor HeLa Cells Humans Indole Alkaloids - chemistry Indole Alkaloids - isolation & purification Indole Alkaloids - pharmacology Marine Biology Molecular Structure Mollusca - chemistry Oxadiazoles - chemistry Oxadiazoles - isolation & purification Oxadiazoles - pharmacology
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Zusammenfassung:	Two indole alkaloids, phidianidines A (1) and B (2), exhibiting an uncommon 1,2,4-oxadiazole ring linked to the indole system, have been isolated from the marine opisthobranch mollusk Phidiana militaris. The structures of the two metabolites have been elucidated by spectroscopic techniques. Phidianidines exhibit high cytotoxicity against tumor and nontumor mammalian cell lines in in vitro assays.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol200234r