Defective deep placentation
Defective deep placentation is characterised by defective remodelling of the utero-placental arteries. Under certain conditions, it is also characterised by the presence of arterial lesions, such as acute atherosis and the persistence of endovascular trophoblast. The condition has been associated wi...
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| Veröffentlicht in: | Best practice & research. Clinical obstetrics & gynaecology 2011-06, Vol.25 (3), p.301-311 |
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| container_title | Best practice & research. Clinical obstetrics & gynaecology |
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| creator | Khong, Yee, MD, PhD Brosens, Ivo, MD, PhD, FRCOG |
| description | Defective deep placentation is characterised by defective remodelling of the utero-placental arteries. Under certain conditions, it is also characterised by the presence of arterial lesions, such as acute atherosis and the persistence of endovascular trophoblast. The condition has been associated with a spectrum of complications during pregnancy, including pre-eclampsia, intrauterine growth restriction, pre-term birth, pre-term premature rupture of membranes, late sporadic miscarriage and abruptio placentae. Criteria are proposed for the classification of defective deep placentation into three types based on the degree of restriction of remodelling and the presence of obstructive lesions in the myometrial segment of the spiral arteries. Although the underlying mechanisms are not understood, evidence is emerging that the origin of defective deep placentation may not lie in primary defect of the trophoblast, but in abnormalities of the endometrium and inner myometrium before or during the early stages of placentation. |
| doi_str_mv | 10.1016/j.bpobgyn.2010.10.012 |
| format | Article |
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Under certain conditions, it is also characterised by the presence of arterial lesions, such as acute atherosis and the persistence of endovascular trophoblast. The condition has been associated with a spectrum of complications during pregnancy, including pre-eclampsia, intrauterine growth restriction, pre-term birth, pre-term premature rupture of membranes, late sporadic miscarriage and abruptio placentae. Criteria are proposed for the classification of defective deep placentation into three types based on the degree of restriction of remodelling and the presence of obstructive lesions in the myometrial segment of the spiral arteries. Although the underlying mechanisms are not understood, evidence is emerging that the origin of defective deep placentation may not lie in primary defect of the trophoblast, but in abnormalities of the endometrium and inner myometrium before or during the early stages of placentation.</description><identifier>ISSN: 1521-6934</identifier><identifier>EISSN: 1532-1932</identifier><identifier>DOI: 10.1016/j.bpobgyn.2010.10.012</identifier><identifier>PMID: 21109492</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>atherosis ; Female ; Humans ; intrauterine growth restriction ; maternal environment ; Obstetrics and Gynecology ; Placenta - blood supply ; Placenta - physiopathology ; Placenta Diseases - physiopathology ; placental bed ; Placentation - physiology ; pre-eclampsia ; Pregnancy ; preterm birth ; remodelling ; spiral artery ; trophoblast</subject><ispartof>Best practice & research. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-277a8ea4d6e4f4070742e6c1ac5689354cf9ff207797e6973777cb26824b952a3</citedby><cites>FETCH-LOGICAL-c419t-277a8ea4d6e4f4070742e6c1ac5689354cf9ff207797e6973777cb26824b952a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bpobgyn.2010.10.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21109492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khong, Yee, MD, PhD</creatorcontrib><creatorcontrib>Brosens, Ivo, MD, PhD, FRCOG</creatorcontrib><title>Defective deep placentation</title><title>Best practice & research. 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Although the underlying mechanisms are not understood, evidence is emerging that the origin of defective deep placentation may not lie in primary defect of the trophoblast, but in abnormalities of the endometrium and inner myometrium before or during the early stages of placentation.</description><subject>atherosis</subject><subject>Female</subject><subject>Humans</subject><subject>intrauterine growth restriction</subject><subject>maternal environment</subject><subject>Obstetrics and Gynecology</subject><subject>Placenta - blood supply</subject><subject>Placenta - physiopathology</subject><subject>Placenta Diseases - physiopathology</subject><subject>placental bed</subject><subject>Placentation - physiology</subject><subject>pre-eclampsia</subject><subject>Pregnancy</subject><subject>preterm birth</subject><subject>remodelling</subject><subject>spiral artery</subject><subject>trophoblast</subject><issn>1521-6934</issn><issn>1532-1932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctOwzAQRS0EoqXwBQjUHasUe_yqNyBUnlIlFsDacpwJckmTEKeV-vcktLBgw2pGozv3as4QcsbohFGmLheTtK7S9005Afo9m1AGe2TIJIeEGQ77fQ8sUYaLATmKcUEp5wbkIRkAY9QIA0Nyeos5-jascZwh1uO6cB7L1rWhKo_JQe6KiCe7OiJv93evs8dk_vzwNLuZJ14w0yagtZuiE5lCkQuqqRaAyjPnpZoaLoXPTZ4D1dpoVEZzrbVPQU1BpEaC4yNysfWtm-pzhbG1yxA9FoUrsVpFO1UKJFDFO6XcKn1TxdhgbusmLF2zsYzaHotd2B0W22Ppxx2Wbu98l7BKl5j9bv1w6ATXWwF2d64DNjb6gKXHLDQdHptV4d-Iqz8Ovghl8K74wA3GRbVqyg6iZTaCpfal_03_GkYpZVxK_gVXHYg_</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Khong, Yee, MD, PhD</creator><creator>Brosens, Ivo, MD, PhD, FRCOG</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Defective deep placentation</title><author>Khong, Yee, MD, PhD ; Brosens, Ivo, MD, PhD, FRCOG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-277a8ea4d6e4f4070742e6c1ac5689354cf9ff207797e6973777cb26824b952a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>atherosis</topic><topic>Female</topic><topic>Humans</topic><topic>intrauterine growth restriction</topic><topic>maternal environment</topic><topic>Obstetrics and Gynecology</topic><topic>Placenta - blood supply</topic><topic>Placenta - physiopathology</topic><topic>Placenta Diseases - physiopathology</topic><topic>placental bed</topic><topic>Placentation - physiology</topic><topic>pre-eclampsia</topic><topic>Pregnancy</topic><topic>preterm birth</topic><topic>remodelling</topic><topic>spiral artery</topic><topic>trophoblast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khong, Yee, MD, PhD</creatorcontrib><creatorcontrib>Brosens, Ivo, MD, PhD, FRCOG</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Best practice & research. 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| ispartof | Best practice & research. Clinical obstetrics & gynaecology, 2011-06, Vol.25 (3), p.301-311 |
| issn | 1521-6934 1532-1932 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | atherosis Female Humans intrauterine growth restriction maternal environment Obstetrics and Gynecology Placenta - blood supply Placenta - physiopathology Placenta Diseases - physiopathology placental bed Placentation - physiology pre-eclampsia Pregnancy preterm birth remodelling spiral artery trophoblast |
| title | Defective deep placentation |
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