Ephrin/ephrin receptor expression during early stages of mouse inner ear development
Ephrins and their tyrosine kinase receptors (Ephs) are a highly conserved family of signaling proteins with various functions during embryonic development. Among others, Eph/ephrin signaling is involved in regulating axon guidance, cell migration, and tissue border formation through inducing modific...
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| Veröffentlicht in: | Developmental dynamics 2011-06, Vol.240 (6), p.1578-1585 |
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| creator | Saeger, Bernhard M. Suhm, Martina Neubüser, Annette |
| description | Ephrins and their tyrosine kinase receptors (Ephs) are a highly conserved family of signaling proteins with various functions during embryonic development. Among others, Eph/ephrin signaling is involved in regulating axon guidance, cell migration, and tissue border formation through inducing modifications of the actin cytoskeleton and cell adhesion. During development ephrins and Ephs are expressed in spatially and temporarily regulated patterns in a wide range of tissues. Here, we analyzed the expression of seven members of the Eph and four member of the ephrin family during early stages of mouse inner ear development by whole‐mount in situ hybridization. We detected expressions of EphA2, EphA4, EphA7, EphB1, ephrinA4, and ephrinA5 in and around the forming otic placode between embryonic day (E) 8.5 and E10, and report their detailed expression patterns. Our results reveal dynamic expression of several members of the ephrin/Eph family consistent with functions in otic placode development, invagination and neuroblast delamination. Developmental Dynamics 240:1578–1585, 2011. © 2011 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/dvdy.22632 |
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Among others, Eph/ephrin signaling is involved in regulating axon guidance, cell migration, and tissue border formation through inducing modifications of the actin cytoskeleton and cell adhesion. During development ephrins and Ephs are expressed in spatially and temporarily regulated patterns in a wide range of tissues. Here, we analyzed the expression of seven members of the Eph and four member of the ephrin family during early stages of mouse inner ear development by whole‐mount in situ hybridization. We detected expressions of EphA2, EphA4, EphA7, EphB1, ephrinA4, and ephrinA5 in and around the forming otic placode between embryonic day (E) 8.5 and E10, and report their detailed expression patterns. Our results reveal dynamic expression of several members of the ephrin/Eph family consistent with functions in otic placode development, invagination and neuroblast delamination. 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Among others, Eph/ephrin signaling is involved in regulating axon guidance, cell migration, and tissue border formation through inducing modifications of the actin cytoskeleton and cell adhesion. During development ephrins and Ephs are expressed in spatially and temporarily regulated patterns in a wide range of tissues. Here, we analyzed the expression of seven members of the Eph and four member of the ephrin family during early stages of mouse inner ear development by whole‐mount in situ hybridization. We detected expressions of EphA2, EphA4, EphA7, EphB1, ephrinA4, and ephrinA5 in and around the forming otic placode between embryonic day (E) 8.5 and E10, and report their detailed expression patterns. Our results reveal dynamic expression of several members of the ephrin/Eph family consistent with functions in otic placode development, invagination and neuroblast delamination. Developmental Dynamics 240:1578–1585, 2011. © 2011 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Ear, Inner - embryology</subject><subject>Ear, Inner - metabolism</subject><subject>Ectoderm - embryology</subject><subject>Ectoderm - metabolism</subject><subject>embryo</subject><subject>ephrin</subject><subject>ephrin receptor</subject><subject>Ephrins - genetics</subject><subject>Ephrins - metabolism</subject><subject>expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>mouse</subject><subject>Organogenesis - genetics</subject><subject>Organogenesis - physiology</subject><subject>otic placode</subject><subject>Receptor, EphB1 - genetics</subject><subject>Receptor, EphB1 - metabolism</subject><subject>Receptors, Eph Family - genetics</subject><subject>Receptors, Eph Family - metabolism</subject><subject>Somites - embryology</subject><subject>Somites - metabolism</subject><subject>Time Factors</subject><issn>1058-8388</issn><issn>1097-0177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9LwzAYhoMobk4v_gGSmyB0S9I07Y6yzR8w8DIFTyFLvs5K29Sknfa_t13Vo6f3g_fh5eNB6JKSKSWEzczetFPGRMiO0JiSeRwQGsfH_R0lQRImyQidef9OCEkEp6doxCgXkWBijDar6s1l5QwOgR1oqGrrMHxVDrzPbIlN0zU7DMrlLfa12oHHNsWFbTzgrCzB9R02sIfcVgWU9Tk6SVXu4eInJ-j5brVZPATrp_vHxe060DwkLDCUG6U4j4kioAyNVBpSHjEhDPAQuKZxQkFFWqeKqrnghIlIM1DbkKQkNuEEXQ-7lbMfDfhaFpnXkOeqhO47mQjB-FxErCNvBlI7672DVFYuK5RrJSWylyh7ifIgsYOvfmabbQHmD_211gF0AD6zHNp_puTyZfk6jH4Dxxt-Ag</recordid><startdate>201106</startdate><enddate>201106</enddate><creator>Saeger, Bernhard M.</creator><creator>Suhm, Martina</creator><creator>Neubüser, Annette</creator><general>Wiley‐Liss, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201106</creationdate><title>Ephrin/ephrin receptor expression during early stages of mouse inner ear development</title><author>Saeger, Bernhard M. ; Suhm, Martina ; Neubüser, Annette</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4302-d14daa4470a0ead15af3145266de43e4c1781ea5ccfa1a9640265c2eab30f07d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Ear, Inner - embryology</topic><topic>Ear, Inner - metabolism</topic><topic>Ectoderm - embryology</topic><topic>Ectoderm - metabolism</topic><topic>embryo</topic><topic>ephrin</topic><topic>ephrin receptor</topic><topic>Ephrins - genetics</topic><topic>Ephrins - metabolism</topic><topic>expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>mouse</topic><topic>Organogenesis - genetics</topic><topic>Organogenesis - physiology</topic><topic>otic placode</topic><topic>Receptor, EphB1 - genetics</topic><topic>Receptor, EphB1 - metabolism</topic><topic>Receptors, Eph Family - genetics</topic><topic>Receptors, Eph Family - metabolism</topic><topic>Somites - embryology</topic><topic>Somites - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saeger, Bernhard M.</creatorcontrib><creatorcontrib>Suhm, Martina</creatorcontrib><creatorcontrib>Neubüser, Annette</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saeger, Bernhard M.</au><au>Suhm, Martina</au><au>Neubüser, Annette</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ephrin/ephrin receptor expression during early stages of mouse inner ear development</atitle><jtitle>Developmental dynamics</jtitle><addtitle>Dev Dyn</addtitle><date>2011-06</date><risdate>2011</risdate><volume>240</volume><issue>6</issue><spage>1578</spage><epage>1585</epage><pages>1578-1585</pages><issn>1058-8388</issn><eissn>1097-0177</eissn><abstract>Ephrins and their tyrosine kinase receptors (Ephs) are a highly conserved family of signaling proteins with various functions during embryonic development. Among others, Eph/ephrin signaling is involved in regulating axon guidance, cell migration, and tissue border formation through inducing modifications of the actin cytoskeleton and cell adhesion. During development ephrins and Ephs are expressed in spatially and temporarily regulated patterns in a wide range of tissues. Here, we analyzed the expression of seven members of the Eph and four member of the ephrin family during early stages of mouse inner ear development by whole‐mount in situ hybridization. We detected expressions of EphA2, EphA4, EphA7, EphB1, ephrinA4, and ephrinA5 in and around the forming otic placode between embryonic day (E) 8.5 and E10, and report their detailed expression patterns. Our results reveal dynamic expression of several members of the ephrin/Eph family consistent with functions in otic placode development, invagination and neuroblast delamination. 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| subjects | Animals Ear, Inner - embryology Ear, Inner - metabolism Ectoderm - embryology Ectoderm - metabolism embryo ephrin ephrin receptor Ephrins - genetics Ephrins - metabolism expression Gene Expression Regulation, Developmental Mice Models, Biological mouse Organogenesis - genetics Organogenesis - physiology otic placode Receptor, EphB1 - genetics Receptor, EphB1 - metabolism Receptors, Eph Family - genetics Receptors, Eph Family - metabolism Somites - embryology Somites - metabolism Time Factors |
| title | Ephrin/ephrin receptor expression during early stages of mouse inner ear development |
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