Lgr4‐deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3

We previously reported that Lgr4 has a critical role in the morphogenesis of kidney, but the detailed functions of Lgr4 in kidney development have not been elucidated. In contrast to Lgr4 null mice with 129Ola × C57BL/6J mixed background, C57BL/6J‐backcrossed Lgr4 null mice (Lgr4−/−) showed the seve...

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Veröffentlicht in:	Developmental dynamics 2011-06, Vol.240 (6), p.1626-1634
Hauptverfasser:	Mohri, Yasuaki, Oyama, Kazunori, Akamatsu, Atsushi, Kato, Shigeki, Nishimori, Katsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Down-Regulation - genetics Female GATA3 Transcription Factor - genetics GATA3 Transcription Factor - metabolism Gene Expression Regulation, Developmental kidney morphogenesis knockout mice Lgr4 Lymphoid Enhancer-Binding Factor 1 - genetics Lymphoid Enhancer-Binding Factor 1 - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Morphogenesis - genetics Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, G-Protein-Coupled - physiology Signal Transduction - genetics Time Factors Ureter - embryology Ureter - metabolism ureteric bud Wnt canonical pathway Wnt Proteins - metabolism
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