Characterization of the micA gene encoding a small regulatory σE-dependent RNA in Salmonella enterica serovar Typhimurium
The role of MicA (repressing small regulatory non-coding RNAs of two Salmonella porins) was determined in virulence of Salmonella enterica serovar Typhimurium. Transcriptional analysis revealed that the expression of the micA gene is driven by a single σ E -dependent promoter, micAp . Its activity i...
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| Veröffentlicht in: | Folia microbiologica 2011, Vol.56 (1), p.59-65 |
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| creator | Homerova, D. Rezuchova, B. Stevenson, A. Skovierova, H. Roberts, M. Kormanec, J. |
| description | The role of MicA (repressing small regulatory non-coding RNAs of two
Salmonella
porins) was determined in virulence of
Salmonella enterica
serovar Typhimurium. Transcriptional analysis revealed that the expression of the
micA
gene is driven by a single σ
E
-dependent promoter,
micAp
. Its activity increased towards stationary phase; in exponential phase, the activity was induced by several stresses by a DegS-dependent mechanism. Although phenotypic analysis revealed no significant differences between wild-type and the
micA
mutant strains, in vivo studies showed that this mutant is more virulent in the mouse model. |
| doi_str_mv | 10.1007/s12223-011-0014-4 |
| format | Article |
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Salmonella
porins) was determined in virulence of
Salmonella enterica
serovar Typhimurium. Transcriptional analysis revealed that the expression of the
micA
gene is driven by a single σ
E
-dependent promoter,
micAp
. Its activity increased towards stationary phase; in exponential phase, the activity was induced by several stresses by a DegS-dependent mechanism. Although phenotypic analysis revealed no significant differences between wild-type and the
micA
mutant strains, in vivo studies showed that this mutant is more virulent in the mouse model.</description><identifier>ISSN: 0015-5632</identifier><identifier>EISSN: 1874-9356</identifier><identifier>DOI: 10.1007/s12223-011-0014-4</identifier><identifier>PMID: 21394477</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animals ; Applied Microbiology ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Base Sequence ; Biomedical and Life Sciences ; Environmental Engineering/Biotechnology ; Female ; Gene Expression Regulation, Bacterial ; Humans ; Immunology ; Life Sciences ; Mice ; Mice, Inbred BALB C ; Microbiology ; Molecular Sequence Data ; RNA, Bacterial - genetics ; RNA, Bacterial - metabolism ; RNA, Untranslated - genetics ; RNA, Untranslated - metabolism ; Salmonella Infections - microbiology ; Salmonella typhimurium - genetics ; Salmonella typhimurium - metabolism ; Salmonella typhimurium - pathogenicity ; Sigma Factor - genetics ; Sigma Factor - metabolism ; Virulence</subject><ispartof>Folia microbiologica, 2011, Vol.56 (1), p.59-65</ispartof><rights>Institute of Microbiology, v.v.i, Academy of Sciences of the Czech Republic 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c273t-eddc4c356d5c0bd76993d527b0fce0b69022a427859d727647f6f322b93309373</citedby><cites>FETCH-LOGICAL-c273t-eddc4c356d5c0bd76993d527b0fce0b69022a427859d727647f6f322b93309373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12223-011-0014-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12223-011-0014-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21394477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Homerova, D.</creatorcontrib><creatorcontrib>Rezuchova, B.</creatorcontrib><creatorcontrib>Stevenson, A.</creatorcontrib><creatorcontrib>Skovierova, H.</creatorcontrib><creatorcontrib>Roberts, M.</creatorcontrib><creatorcontrib>Kormanec, J.</creatorcontrib><title>Characterization of the micA gene encoding a small regulatory σE-dependent RNA in Salmonella enterica serovar Typhimurium</title><title>Folia microbiologica</title><addtitle>Folia Microbiol</addtitle><addtitle>Folia Microbiol (Praha)</addtitle><description>The role of MicA (repressing small regulatory non-coding RNAs of two
Salmonella
porins) was determined in virulence of
Salmonella enterica
serovar Typhimurium. Transcriptional analysis revealed that the expression of the
micA
gene is driven by a single σ
E
-dependent promoter,
micAp
. Its activity increased towards stationary phase; in exponential phase, the activity was induced by several stresses by a DegS-dependent mechanism. Although phenotypic analysis revealed no significant differences between wild-type and the
micA
mutant strains, in vivo studies showed that this mutant is more virulent in the mouse model.</description><subject>Animals</subject><subject>Applied Microbiology</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Base Sequence</subject><subject>Biomedical and Life Sciences</subject><subject>Environmental Engineering/Biotechnology</subject><subject>Female</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Humans</subject><subject>Immunology</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>RNA, Bacterial - genetics</subject><subject>RNA, Bacterial - metabolism</subject><subject>RNA, Untranslated - genetics</subject><subject>RNA, Untranslated - metabolism</subject><subject>Salmonella Infections - microbiology</subject><subject>Salmonella typhimurium - genetics</subject><subject>Salmonella typhimurium - metabolism</subject><subject>Salmonella typhimurium - pathogenicity</subject><subject>Sigma Factor - genetics</subject><subject>Sigma Factor - metabolism</subject><subject>Virulence</subject><issn>0015-5632</issn><issn>1874-9356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1qGzEUhUVpaNy0D9BN0K4rpfqbkWdpTJoEQgNJuhYa6Y4tMyO50kzA3vYB80qRsdNlVxfuPedwz4fQN0avGKXqR2acc0EoY4RSJon8gGZsriRpRFV_RLOyrEhVC36OPue8obSmUvBP6Jwz0Uip1Aztl2uTjB0h-b0ZfQw4dnhcAx68XeAVBMAQbHQ-rLDBeTB9jxOspt6MMe3w699r4mALwUEY8eOvBfYBP5l-iAH63hTvIdkWJ6T4YhJ-3m3XfpiSn4Yv6KwzfYavp3mBfv-8fl7ekvuHm7vl4p5YrsRIwDkrbSnkKktbp-qmEa7iqqWdBdrWDeXcSK7mVeMUV7VUXd0JzttGCNoIJS7Q92PuNsU_E-RRDz7bw3sB4pT1vC5YKsmromRHpU0x5wSd3iY_mLTTjOoDcX0krgtxfSCuZfFcntKndgD3z_GOuAj4UZDLKawg6U2cUiiN_5P6BvwxjM0</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Homerova, D.</creator><creator>Rezuchova, B.</creator><creator>Stevenson, A.</creator><creator>Skovierova, H.</creator><creator>Roberts, M.</creator><creator>Kormanec, J.</creator><general>Springer Netherlands</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Characterization of the micA gene encoding a small regulatory σE-dependent RNA in Salmonella enterica serovar Typhimurium</title><author>Homerova, D. ; Rezuchova, B. ; Stevenson, A. ; Skovierova, H. ; Roberts, M. ; Kormanec, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c273t-eddc4c356d5c0bd76993d527b0fce0b69022a427859d727647f6f322b93309373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Applied Microbiology</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>Base Sequence</topic><topic>Biomedical and Life Sciences</topic><topic>Environmental Engineering/Biotechnology</topic><topic>Female</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Humans</topic><topic>Immunology</topic><topic>Life Sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>RNA, Bacterial - genetics</topic><topic>RNA, Bacterial - metabolism</topic><topic>RNA, Untranslated - genetics</topic><topic>RNA, Untranslated - metabolism</topic><topic>Salmonella Infections - microbiology</topic><topic>Salmonella typhimurium - genetics</topic><topic>Salmonella typhimurium - metabolism</topic><topic>Salmonella typhimurium - pathogenicity</topic><topic>Sigma Factor - genetics</topic><topic>Sigma Factor - metabolism</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Homerova, D.</creatorcontrib><creatorcontrib>Rezuchova, B.</creatorcontrib><creatorcontrib>Stevenson, A.</creatorcontrib><creatorcontrib>Skovierova, H.</creatorcontrib><creatorcontrib>Roberts, M.</creatorcontrib><creatorcontrib>Kormanec, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Folia microbiologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Homerova, D.</au><au>Rezuchova, B.</au><au>Stevenson, A.</au><au>Skovierova, H.</au><au>Roberts, M.</au><au>Kormanec, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of the micA gene encoding a small regulatory σE-dependent RNA in Salmonella enterica serovar Typhimurium</atitle><jtitle>Folia microbiologica</jtitle><stitle>Folia Microbiol</stitle><addtitle>Folia Microbiol (Praha)</addtitle><date>2011</date><risdate>2011</risdate><volume>56</volume><issue>1</issue><spage>59</spage><epage>65</epage><pages>59-65</pages><issn>0015-5632</issn><eissn>1874-9356</eissn><abstract>The role of MicA (repressing small regulatory non-coding RNAs of two
Salmonella
porins) was determined in virulence of
Salmonella enterica
serovar Typhimurium. Transcriptional analysis revealed that the expression of the
micA
gene is driven by a single σ
E
-dependent promoter,
micAp
. Its activity increased towards stationary phase; in exponential phase, the activity was induced by several stresses by a DegS-dependent mechanism. Although phenotypic analysis revealed no significant differences between wild-type and the
micA
mutant strains, in vivo studies showed that this mutant is more virulent in the mouse model.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>21394477</pmid><doi>10.1007/s12223-011-0014-4</doi><tpages>7</tpages></addata></record> |
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| ispartof | Folia microbiologica, 2011, Vol.56 (1), p.59-65 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Applied Microbiology Bacterial Proteins - genetics Bacterial Proteins - metabolism Base Sequence Biomedical and Life Sciences Environmental Engineering/Biotechnology Female Gene Expression Regulation, Bacterial Humans Immunology Life Sciences Mice Mice, Inbred BALB C Microbiology Molecular Sequence Data RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Untranslated - genetics RNA, Untranslated - metabolism Salmonella Infections - microbiology Salmonella typhimurium - genetics Salmonella typhimurium - metabolism Salmonella typhimurium - pathogenicity Sigma Factor - genetics Sigma Factor - metabolism Virulence |
| title | Characterization of the micA gene encoding a small regulatory σE-dependent RNA in Salmonella enterica serovar Typhimurium |
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