High prevalence of antiretroviral drug resistance among HIV―1―untreated patients in Guinea―Conakry and in Niger
The aim of the study was to assess the prevalence of antiretroviral drug resistance mutations in HIV-1 from recently diagnosed and untreated patients living in Conakry, Guinea-Conakry and in Niamey, Niger. The study was performed in two countries of Western Africa - Guinea-Conakry and Niger - using...
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| Veröffentlicht in: | Antiviral therapy 2011-01, Vol.16 (3), p.429-433 |
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| creator | CHARPENTIER, Charlotte BELLECAVE, Pantxika BRUN-VEZINET, Françoise KATLAMA, Christine CALVEZ, Vincent MARCELIN, Anne-Geneviève MASQUELIER, Bernard DESCAMPS, Diane CISSE, Mohamed MAMADOU, Saidou DIAKITE, Mandiou PEYTAVIN, Gilles TCHIOMBIANO, Stéphanie TEISSEIRE, Pierre PIZARRO, Louis STORTO, Alexandre |
| description | The aim of the study was to assess the prevalence of antiretroviral drug resistance mutations in HIV-1 from recently diagnosed and untreated patients living in Conakry, Guinea-Conakry and in Niamey, Niger.
The study was performed in two countries of Western Africa - Guinea-Conakry and Niger - using the same survey method in both sites. All newly HIV-1 diagnosed patients, naive of antiretroviral drugs, were consecutively included during September 2009 in each of the two sites. Protease and reverse transcriptase sequencing was performed using the ANRS procedures. Drug resistance mutations were identified according to the 2009 update surveillance drug resistance mutations.
In Conakry, 99 patients were included, most of whom (89%) were infected with CRF02_AG recombinant virus. Resistance analysis among the 93 samples showed that ≥1 drug resistance mutation was observed in 8 samples, leading to a prevalence of primary resistance of 8.6% (95% CI 2.91-14.29%). In Niamey, 96 patients were included; a high diversity in HIV-1 subtypes was observed with 47 (51%) patients infected with CRF02_AG. Resistance analysis performed among the 92 samples with successful genotypic resistance test showed that ≥1 drug resistance mutation was observed in 6 samples, leading to a prevalence of primary resistance of 6.5% (95% CI 1.50-11.50%).
We reported the first antiretroviral drug resistance survey studies in antiretroviral-naive patients living in Guinea-Conakry and in Niger. The prevalence of resistance was between 6% and 9% in both sites, which is higher than most of the other countries from Western Africa region. |
| doi_str_mv | 10.3851/IMP1754 |
| format | Article |
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The study was performed in two countries of Western Africa - Guinea-Conakry and Niger - using the same survey method in both sites. All newly HIV-1 diagnosed patients, naive of antiretroviral drugs, were consecutively included during September 2009 in each of the two sites. Protease and reverse transcriptase sequencing was performed using the ANRS procedures. Drug resistance mutations were identified according to the 2009 update surveillance drug resistance mutations.
In Conakry, 99 patients were included, most of whom (89%) were infected with CRF02_AG recombinant virus. Resistance analysis among the 93 samples showed that ≥1 drug resistance mutation was observed in 8 samples, leading to a prevalence of primary resistance of 8.6% (95% CI 2.91-14.29%). In Niamey, 96 patients were included; a high diversity in HIV-1 subtypes was observed with 47 (51%) patients infected with CRF02_AG. Resistance analysis performed among the 92 samples with successful genotypic resistance test showed that ≥1 drug resistance mutation was observed in 6 samples, leading to a prevalence of primary resistance of 6.5% (95% CI 1.50-11.50%).
We reported the first antiretroviral drug resistance survey studies in antiretroviral-naive patients living in Guinea-Conakry and in Niger. The prevalence of resistance was between 6% and 9% in both sites, which is higher than most of the other countries from Western Africa region.</description><identifier>ISSN: 1359-6535</identifier><identifier>EISSN: 2040-2058</identifier><identifier>DOI: 10.3851/IMP1754</identifier><identifier>PMID: 21555827</identifier><language>eng</language><publisher>London: International Medical Press</publisher><subject>Adult ; Africa, Western - epidemiology ; Anti-HIV Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Biological and medical sciences ; Drug Resistance, Viral - genetics ; Female ; HIV Infections - diagnosis ; HIV Infections - epidemiology ; HIV Infections - virology ; HIV Protease - genetics ; HIV Protease Inhibitors - pharmacology ; HIV Reverse Transcriptase - genetics ; HIV-1 - drug effects ; HIV-1 - enzymology ; HIV-1 - genetics ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Mutation ; Niger - epidemiology ; Pharmacology. Drug treatments ; Prevalence ; Reverse Transcriptase Inhibitors - pharmacology ; RNA, Viral - genetics ; Sequence Analysis, DNA ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Antiviral therapy, 2011-01, Vol.16 (3), p.429-433</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c310t-696b958f3c94823b0d26dabac30a5aa90d9cd246f663149977bd1aceba50d28e3</citedby><cites>FETCH-LOGICAL-c310t-696b958f3c94823b0d26dabac30a5aa90d9cd246f663149977bd1aceba50d28e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24230670$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21555827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHARPENTIER, Charlotte</creatorcontrib><creatorcontrib>BELLECAVE, Pantxika</creatorcontrib><creatorcontrib>BRUN-VEZINET, Françoise</creatorcontrib><creatorcontrib>KATLAMA, Christine</creatorcontrib><creatorcontrib>CALVEZ, Vincent</creatorcontrib><creatorcontrib>MARCELIN, Anne-Geneviève</creatorcontrib><creatorcontrib>MASQUELIER, Bernard</creatorcontrib><creatorcontrib>DESCAMPS, Diane</creatorcontrib><creatorcontrib>CISSE, Mohamed</creatorcontrib><creatorcontrib>MAMADOU, Saidou</creatorcontrib><creatorcontrib>DIAKITE, Mandiou</creatorcontrib><creatorcontrib>PEYTAVIN, Gilles</creatorcontrib><creatorcontrib>TCHIOMBIANO, Stéphanie</creatorcontrib><creatorcontrib>TEISSEIRE, Pierre</creatorcontrib><creatorcontrib>PIZARRO, Louis</creatorcontrib><creatorcontrib>STORTO, Alexandre</creatorcontrib><title>High prevalence of antiretroviral drug resistance among HIV―1―untreated patients in Guinea―Conakry and in Niger</title><title>Antiviral therapy</title><addtitle>Antivir Ther</addtitle><description>The aim of the study was to assess the prevalence of antiretroviral drug resistance mutations in HIV-1 from recently diagnosed and untreated patients living in Conakry, Guinea-Conakry and in Niamey, Niger.
The study was performed in two countries of Western Africa - Guinea-Conakry and Niger - using the same survey method in both sites. All newly HIV-1 diagnosed patients, naive of antiretroviral drugs, were consecutively included during September 2009 in each of the two sites. Protease and reverse transcriptase sequencing was performed using the ANRS procedures. Drug resistance mutations were identified according to the 2009 update surveillance drug resistance mutations.
In Conakry, 99 patients were included, most of whom (89%) were infected with CRF02_AG recombinant virus. Resistance analysis among the 93 samples showed that ≥1 drug resistance mutation was observed in 8 samples, leading to a prevalence of primary resistance of 8.6% (95% CI 2.91-14.29%). In Niamey, 96 patients were included; a high diversity in HIV-1 subtypes was observed with 47 (51%) patients infected with CRF02_AG. Resistance analysis performed among the 92 samples with successful genotypic resistance test showed that ≥1 drug resistance mutation was observed in 6 samples, leading to a prevalence of primary resistance of 6.5% (95% CI 1.50-11.50%).
We reported the first antiretroviral drug resistance survey studies in antiretroviral-naive patients living in Guinea-Conakry and in Niger. The prevalence of resistance was between 6% and 9% in both sites, which is higher than most of the other countries from Western Africa region.</description><subject>Adult</subject><subject>Africa, Western - epidemiology</subject><subject>Anti-HIV Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Drug Resistance, Viral - genetics</subject><subject>Female</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - virology</subject><subject>HIV Protease - genetics</subject><subject>HIV Protease Inhibitors - pharmacology</subject><subject>HIV Reverse Transcriptase - genetics</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - enzymology</subject><subject>HIV-1 - genetics</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Niger - epidemiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prevalence</subject><subject>Reverse Transcriptase Inhibitors - pharmacology</subject><subject>RNA, Viral - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>1359-6535</issn><issn>2040-2058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0M1O3DAUhmGroioDVNwB8gaxSuuf2ImX1QiYkaDtonQbndgng2nGmdrOSOy4CW6QKyGjTmFhWbIffYuXkFPOvsha8a_L25-8UuUHMhOsZIVgqj4gMy6VKbSS6pAcpfTAmKgNY5_IoeBKqVpUMzIu_OqebiJuocdgkQ4dhZB9xByHrY_QUxfHFY2YfMqwE7Aewooulr9fnp75dMaQI0JGRzeQPYacqA_0evQBYfqeDwH-xMdp1e3ev_sVxhPysYM-4ef9fUzuri5_zRfFzY_r5fzbTWElZ7nQRrdG1Z20pqyFbJkT2kELVjJQAIY5Y50odae15KUxVdU6DhZbUBOtUR6Ti3-7mzj8HTHlZu2Txb6HgMOYmlprVoqpxru0cUgpYtdsol9DfGw4a3aJm33iSZ7tN8d2je7N_W86gfM9gGSh7-JUzad3VwrJdMXkK-mrhw0</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>CHARPENTIER, Charlotte</creator><creator>BELLECAVE, Pantxika</creator><creator>BRUN-VEZINET, Françoise</creator><creator>KATLAMA, Christine</creator><creator>CALVEZ, Vincent</creator><creator>MARCELIN, Anne-Geneviève</creator><creator>MASQUELIER, Bernard</creator><creator>DESCAMPS, Diane</creator><creator>CISSE, Mohamed</creator><creator>MAMADOU, Saidou</creator><creator>DIAKITE, Mandiou</creator><creator>PEYTAVIN, Gilles</creator><creator>TCHIOMBIANO, Stéphanie</creator><creator>TEISSEIRE, Pierre</creator><creator>PIZARRO, Louis</creator><creator>STORTO, Alexandre</creator><general>International Medical Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110101</creationdate><title>High prevalence of antiretroviral drug resistance among HIV―1―untreated patients in Guinea―Conakry and in Niger</title><author>CHARPENTIER, Charlotte ; BELLECAVE, Pantxika ; BRUN-VEZINET, Françoise ; KATLAMA, Christine ; CALVEZ, Vincent ; MARCELIN, Anne-Geneviève ; MASQUELIER, Bernard ; DESCAMPS, Diane ; CISSE, Mohamed ; MAMADOU, Saidou ; DIAKITE, Mandiou ; PEYTAVIN, Gilles ; TCHIOMBIANO, Stéphanie ; TEISSEIRE, Pierre ; PIZARRO, Louis ; STORTO, Alexandre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-696b958f3c94823b0d26dabac30a5aa90d9cd246f663149977bd1aceba50d28e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Africa, Western - epidemiology</topic><topic>Anti-HIV Agents - pharmacology</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Drug Resistance, Viral - genetics</topic><topic>Female</topic><topic>HIV Infections - diagnosis</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - virology</topic><topic>HIV Protease - genetics</topic><topic>HIV Protease Inhibitors - pharmacology</topic><topic>HIV Reverse Transcriptase - genetics</topic><topic>HIV-1 - drug effects</topic><topic>HIV-1 - enzymology</topic><topic>HIV-1 - genetics</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Niger - epidemiology</topic><topic>Pharmacology. 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Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHARPENTIER, Charlotte</creatorcontrib><creatorcontrib>BELLECAVE, Pantxika</creatorcontrib><creatorcontrib>BRUN-VEZINET, Françoise</creatorcontrib><creatorcontrib>KATLAMA, Christine</creatorcontrib><creatorcontrib>CALVEZ, Vincent</creatorcontrib><creatorcontrib>MARCELIN, Anne-Geneviève</creatorcontrib><creatorcontrib>MASQUELIER, Bernard</creatorcontrib><creatorcontrib>DESCAMPS, Diane</creatorcontrib><creatorcontrib>CISSE, Mohamed</creatorcontrib><creatorcontrib>MAMADOU, Saidou</creatorcontrib><creatorcontrib>DIAKITE, Mandiou</creatorcontrib><creatorcontrib>PEYTAVIN, Gilles</creatorcontrib><creatorcontrib>TCHIOMBIANO, Stéphanie</creatorcontrib><creatorcontrib>TEISSEIRE, Pierre</creatorcontrib><creatorcontrib>PIZARRO, Louis</creatorcontrib><creatorcontrib>STORTO, Alexandre</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Antiviral therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHARPENTIER, Charlotte</au><au>BELLECAVE, Pantxika</au><au>BRUN-VEZINET, Françoise</au><au>KATLAMA, Christine</au><au>CALVEZ, Vincent</au><au>MARCELIN, Anne-Geneviève</au><au>MASQUELIER, Bernard</au><au>DESCAMPS, Diane</au><au>CISSE, Mohamed</au><au>MAMADOU, Saidou</au><au>DIAKITE, Mandiou</au><au>PEYTAVIN, Gilles</au><au>TCHIOMBIANO, Stéphanie</au><au>TEISSEIRE, Pierre</au><au>PIZARRO, Louis</au><au>STORTO, Alexandre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of antiretroviral drug resistance among HIV―1―untreated patients in Guinea―Conakry and in Niger</atitle><jtitle>Antiviral therapy</jtitle><addtitle>Antivir Ther</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>16</volume><issue>3</issue><spage>429</spage><epage>433</epage><pages>429-433</pages><issn>1359-6535</issn><eissn>2040-2058</eissn><abstract>The aim of the study was to assess the prevalence of antiretroviral drug resistance mutations in HIV-1 from recently diagnosed and untreated patients living in Conakry, Guinea-Conakry and in Niamey, Niger.
The study was performed in two countries of Western Africa - Guinea-Conakry and Niger - using the same survey method in both sites. All newly HIV-1 diagnosed patients, naive of antiretroviral drugs, were consecutively included during September 2009 in each of the two sites. Protease and reverse transcriptase sequencing was performed using the ANRS procedures. Drug resistance mutations were identified according to the 2009 update surveillance drug resistance mutations.
In Conakry, 99 patients were included, most of whom (89%) were infected with CRF02_AG recombinant virus. Resistance analysis among the 93 samples showed that ≥1 drug resistance mutation was observed in 8 samples, leading to a prevalence of primary resistance of 8.6% (95% CI 2.91-14.29%). In Niamey, 96 patients were included; a high diversity in HIV-1 subtypes was observed with 47 (51%) patients infected with CRF02_AG. Resistance analysis performed among the 92 samples with successful genotypic resistance test showed that ≥1 drug resistance mutation was observed in 6 samples, leading to a prevalence of primary resistance of 6.5% (95% CI 1.50-11.50%).
We reported the first antiretroviral drug resistance survey studies in antiretroviral-naive patients living in Guinea-Conakry and in Niger. The prevalence of resistance was between 6% and 9% in both sites, which is higher than most of the other countries from Western Africa region.</abstract><cop>London</cop><pub>International Medical Press</pub><pmid>21555827</pmid><doi>10.3851/IMP1754</doi><tpages>5</tpages></addata></record> |
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| ispartof | Antiviral therapy, 2011-01, Vol.16 (3), p.429-433 |
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| subjects | Adult Africa, Western - epidemiology Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Drug Resistance, Viral - genetics Female HIV Infections - diagnosis HIV Infections - epidemiology HIV Infections - virology HIV Protease - genetics HIV Protease Inhibitors - pharmacology HIV Reverse Transcriptase - genetics HIV-1 - drug effects HIV-1 - enzymology HIV-1 - genetics Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Middle Aged Molecular Sequence Data Mutation Niger - epidemiology Pharmacology. Drug treatments Prevalence Reverse Transcriptase Inhibitors - pharmacology RNA, Viral - genetics Sequence Analysis, DNA Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | High prevalence of antiretroviral drug resistance among HIV―1―untreated patients in Guinea―Conakry and in Niger |
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