Protective effects of the dietary supplementation of turmeric (Curcuma longa L.) on sodium arsenite-induced biochemical perturbation in mice
The present study was undertaken to evaluate the protective effect of turmeric powder on arsenic toxicity through mice model. Swiss albino male mice were divided into four groups. The first group was used as control, while groups 2, 3, and 4 were treated with turmeric powder (T, 50 mg/kg body weight...
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| Veröffentlicht in: | Bangladesh Medical Research Council bulletin 2010-12, Vol.36 (3), p.82-88 |
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| creator | Karim, Md Rezaul Haque, Abedul Islam, Khairul Ali, Nurshad Salam, Kazi Abdus Saud, Zahangir Alam Hossain, Ekhtear Fajol, Abul Akhand, Anwarul Azim Himeno, Seiichiro Hossain, Khaled |
| description | The present study was undertaken to evaluate the protective effect of turmeric powder on arsenic toxicity through mice model. Swiss albino male mice were divided into four groups. The first group was used as control, while groups 2, 3, and 4 were treated with turmeric powder (T, 50 mg/kg body weight/day), sodium arsenite (Sa, 10 mg/kg body weight/day) and turmeric plus Sa (T+Sa), respectively. Results showed that oral administration of Sa reduced the weight gain of the mice compared to the control group and food supplementation of turmeric prevented the reduction of weight gain. Turmeric abrogated the Sa-induced elevation of serum urea, glucose, triglyceride (TG) level and alanine aminotransferase (ALT) activity except the activity of alkaline phosphatase (ALP). Turmeric also prevented the Sa-induced perturbation of serum butyryl cholinesterase activity (BChE). Therefore, ameliorating effect of turmeric on Sa-treated mice suggested the future application of turmeric to reduce or to prevent arsenic toxicity in human. |
| doi_str_mv | 10.3329/bmrcb.v36i3.7287 |
| format | Article |
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Swiss albino male mice were divided into four groups. The first group was used as control, while groups 2, 3, and 4 were treated with turmeric powder (T, 50 mg/kg body weight/day), sodium arsenite (Sa, 10 mg/kg body weight/day) and turmeric plus Sa (T+Sa), respectively. Results showed that oral administration of Sa reduced the weight gain of the mice compared to the control group and food supplementation of turmeric prevented the reduction of weight gain. Turmeric abrogated the Sa-induced elevation of serum urea, glucose, triglyceride (TG) level and alanine aminotransferase (ALT) activity except the activity of alkaline phosphatase (ALP). Turmeric also prevented the Sa-induced perturbation of serum butyryl cholinesterase activity (BChE). Therefore, ameliorating effect of turmeric on Sa-treated mice suggested the future application of turmeric to reduce or to prevent arsenic toxicity in human.</description><identifier>ISSN: 0377-9238</identifier><identifier>EISSN: 2224-7238</identifier><identifier>DOI: 10.3329/bmrcb.v36i3.7287</identifier><identifier>PMID: 21548544</identifier><language>eng</language><publisher>Bangladesh</publisher><subject>Animals ; Antioxidants - administration & dosage ; Arsenic Poisoning - prevention & control ; Arsenites - poisoning ; Curcuma ; Dietary Supplements ; Male ; Mice ; Plant Preparations - administration & dosage ; Sodium Compounds - poisoning</subject><ispartof>Bangladesh Medical Research Council bulletin, 2010-12, Vol.36 (3), p.82-88</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c279t-166ef0442fc8e48a8c514d4478e38e79b0d6ee18b0142d47709c42a5feac44113</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4113,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21548544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karim, Md Rezaul</creatorcontrib><creatorcontrib>Haque, Abedul</creatorcontrib><creatorcontrib>Islam, Khairul</creatorcontrib><creatorcontrib>Ali, Nurshad</creatorcontrib><creatorcontrib>Salam, Kazi Abdus</creatorcontrib><creatorcontrib>Saud, Zahangir Alam</creatorcontrib><creatorcontrib>Hossain, Ekhtear</creatorcontrib><creatorcontrib>Fajol, Abul</creatorcontrib><creatorcontrib>Akhand, Anwarul Azim</creatorcontrib><creatorcontrib>Himeno, Seiichiro</creatorcontrib><creatorcontrib>Hossain, Khaled</creatorcontrib><title>Protective effects of the dietary supplementation of turmeric (Curcuma longa L.) on sodium arsenite-induced biochemical perturbation in mice</title><title>Bangladesh Medical Research Council bulletin</title><addtitle>Bangladesh Med Res Counc Bull</addtitle><description>The present study was undertaken to evaluate the protective effect of turmeric powder on arsenic toxicity through mice model. Swiss albino male mice were divided into four groups. The first group was used as control, while groups 2, 3, and 4 were treated with turmeric powder (T, 50 mg/kg body weight/day), sodium arsenite (Sa, 10 mg/kg body weight/day) and turmeric plus Sa (T+Sa), respectively. Results showed that oral administration of Sa reduced the weight gain of the mice compared to the control group and food supplementation of turmeric prevented the reduction of weight gain. Turmeric abrogated the Sa-induced elevation of serum urea, glucose, triglyceride (TG) level and alanine aminotransferase (ALT) activity except the activity of alkaline phosphatase (ALP). Turmeric also prevented the Sa-induced perturbation of serum butyryl cholinesterase activity (BChE). Therefore, ameliorating effect of turmeric on Sa-treated mice suggested the future application of turmeric to reduce or to prevent arsenic toxicity in human.</description><subject>Animals</subject><subject>Antioxidants - administration & dosage</subject><subject>Arsenic Poisoning - prevention & control</subject><subject>Arsenites - poisoning</subject><subject>Curcuma</subject><subject>Dietary Supplements</subject><subject>Male</subject><subject>Mice</subject><subject>Plant Preparations - administration & dosage</subject><subject>Sodium Compounds - poisoning</subject><issn>0377-9238</issn><issn>2224-7238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9Ubtu3DAQJIwY9uHi3lXALnEhmS-JVBkc7CTAAUlh1wJFrWwGoqjwYcD_kI82fXfJNjvYnZliBqFrSmrOWXc7uGCG-oW3lteSKXmGNowxUUnG1Qe0IVzKqiv4El3F-JuUKSre8At0yWgjVCPEBv39FXwCk-wLYJimgiL2E07PgEcLSYdXHPO6zuBgSTpZvxzeOTgI1uAvuxxMdhrPfnnSeF_f4MKIfrTZYR0iLDZBZZcxGxjxYL15BmeNnvEKobgMR0u74HKFj-h80nOEq9Peosf7u4fd92r_89uP3dd9ZZjsUkXbFiYiBJuMAqG0Mg0VoxBSAVcgu4GMLQBVA6GCjUJK0hnBdDOBNkJQyrfo89F3Df5Phph6Z6OBedYL-Bx71TZt13LKC5McmSb4GANM_RqsK6n0lPTvLfSHFvpDC_17C0Xy6WSeBwfjf8G_zPkbx52HAA</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Karim, Md Rezaul</creator><creator>Haque, Abedul</creator><creator>Islam, Khairul</creator><creator>Ali, Nurshad</creator><creator>Salam, Kazi Abdus</creator><creator>Saud, Zahangir Alam</creator><creator>Hossain, Ekhtear</creator><creator>Fajol, Abul</creator><creator>Akhand, Anwarul Azim</creator><creator>Himeno, Seiichiro</creator><creator>Hossain, Khaled</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201012</creationdate><title>Protective effects of the dietary supplementation of turmeric (Curcuma longa L.) on sodium arsenite-induced biochemical perturbation in mice</title><author>Karim, Md Rezaul ; Haque, Abedul ; Islam, Khairul ; Ali, Nurshad ; Salam, Kazi Abdus ; Saud, Zahangir Alam ; Hossain, Ekhtear ; Fajol, Abul ; Akhand, Anwarul Azim ; Himeno, Seiichiro ; Hossain, Khaled</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c279t-166ef0442fc8e48a8c514d4478e38e79b0d6ee18b0142d47709c42a5feac44113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Antioxidants - administration & dosage</topic><topic>Arsenic Poisoning - prevention & control</topic><topic>Arsenites - poisoning</topic><topic>Curcuma</topic><topic>Dietary Supplements</topic><topic>Male</topic><topic>Mice</topic><topic>Plant Preparations - administration & dosage</topic><topic>Sodium Compounds - poisoning</topic><toplevel>online_resources</toplevel><creatorcontrib>Karim, Md Rezaul</creatorcontrib><creatorcontrib>Haque, Abedul</creatorcontrib><creatorcontrib>Islam, Khairul</creatorcontrib><creatorcontrib>Ali, Nurshad</creatorcontrib><creatorcontrib>Salam, Kazi Abdus</creatorcontrib><creatorcontrib>Saud, Zahangir Alam</creatorcontrib><creatorcontrib>Hossain, Ekhtear</creatorcontrib><creatorcontrib>Fajol, Abul</creatorcontrib><creatorcontrib>Akhand, Anwarul Azim</creatorcontrib><creatorcontrib>Himeno, Seiichiro</creatorcontrib><creatorcontrib>Hossain, Khaled</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bangladesh Medical Research Council bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karim, Md Rezaul</au><au>Haque, Abedul</au><au>Islam, Khairul</au><au>Ali, Nurshad</au><au>Salam, Kazi Abdus</au><au>Saud, Zahangir Alam</au><au>Hossain, Ekhtear</au><au>Fajol, Abul</au><au>Akhand, Anwarul Azim</au><au>Himeno, Seiichiro</au><au>Hossain, Khaled</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of the dietary supplementation of turmeric (Curcuma longa L.) on sodium arsenite-induced biochemical perturbation in mice</atitle><jtitle>Bangladesh Medical Research Council bulletin</jtitle><addtitle>Bangladesh Med Res Counc Bull</addtitle><date>2010-12</date><risdate>2010</risdate><volume>36</volume><issue>3</issue><spage>82</spage><epage>88</epage><pages>82-88</pages><issn>0377-9238</issn><eissn>2224-7238</eissn><abstract>The present study was undertaken to evaluate the protective effect of turmeric powder on arsenic toxicity through mice model. Swiss albino male mice were divided into four groups. The first group was used as control, while groups 2, 3, and 4 were treated with turmeric powder (T, 50 mg/kg body weight/day), sodium arsenite (Sa, 10 mg/kg body weight/day) and turmeric plus Sa (T+Sa), respectively. Results showed that oral administration of Sa reduced the weight gain of the mice compared to the control group and food supplementation of turmeric prevented the reduction of weight gain. Turmeric abrogated the Sa-induced elevation of serum urea, glucose, triglyceride (TG) level and alanine aminotransferase (ALT) activity except the activity of alkaline phosphatase (ALP). Turmeric also prevented the Sa-induced perturbation of serum butyryl cholinesterase activity (BChE). Therefore, ameliorating effect of turmeric on Sa-treated mice suggested the future application of turmeric to reduce or to prevent arsenic toxicity in human.</abstract><cop>Bangladesh</cop><pmid>21548544</pmid><doi>10.3329/bmrcb.v36i3.7287</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Bangladesh Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antioxidants - administration & dosage Arsenic Poisoning - prevention & control Arsenites - poisoning Curcuma Dietary Supplements Male Mice Plant Preparations - administration & dosage Sodium Compounds - poisoning |
| title | Protective effects of the dietary supplementation of turmeric (Curcuma longa L.) on sodium arsenite-induced biochemical perturbation in mice |
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