Left ventricular hypertrophy is associated with inflammation in sodium loaded subtotal nephrectomized rats
The pathological influences of inflammation on left ventricular hypertrophy (LVH) were studied in subtotal nephrectomized (SNx) rats after 0.3% NaCl loading for 5 weeks. We found that mild hypertension, increased plasma levels of creatinine, inorganic phosphate, asymmetric dimethylarginine (ADMA), a...
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| Veröffentlicht in: | Biomedical Research 2011, Vol.32(2), pp.83-90 |
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| creator | Moriguchi, Yoshiyuki Yogo, Kenji Aizawa, Ken Serizawa, Ken-ichi Tashiro, Yoshihito Yorozu, Keigo Ishizuka, Nobuhiko Iwabuchi, Sadahiro Kitamura, Hidemitsu Nishimura, Takashi |
| description | The pathological influences of inflammation on left ventricular hypertrophy (LVH) were studied in subtotal nephrectomized (SNx) rats after 0.3% NaCl loading for 5 weeks. We found that mild hypertension, increased plasma levels of creatinine, inorganic phosphate, asymmetric dimethylarginine (ADMA), and parathyroid hormone (PTH) were observed in the present SNx rats without LVH. In the present study, the NaCl-loaded SNx (SNx + NaCl) rats were characterized by significant LVH and hypertension with aggravated values of all the parameters. We further confirmed that glomerular sclerosis, tubulointerstitial fibrosis, and inflammatory cell infiltration into the tubulointerstitial area, observed in the SNx rats, were more severely caused in the SNx + NaCl rats. In addition, plasma interleukin-6 (IL-6) levels in the SNx + NaCl rats were significantly increased compared to those in the SNx rats. These findings indicated that NaCl-loaded SNx rats developed LVH and hypertension, which were accompanied with increased plasma levels of PTH, creatinine, inorganic phosphorus, ADMA, and IL-6. Thus, these results suggest that inflammation as well as endothelial dysfunction would be correlated with LVH as non-traditional risk factors at the early stage in the present renal failure model. |
| doi_str_mv | 10.2220/biomedres.32.83 |
| format | Article |
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We found that mild hypertension, increased plasma levels of creatinine, inorganic phosphate, asymmetric dimethylarginine (ADMA), and parathyroid hormone (PTH) were observed in the present SNx rats without LVH. In the present study, the NaCl-loaded SNx (SNx + NaCl) rats were characterized by significant LVH and hypertension with aggravated values of all the parameters. We further confirmed that glomerular sclerosis, tubulointerstitial fibrosis, and inflammatory cell infiltration into the tubulointerstitial area, observed in the SNx rats, were more severely caused in the SNx + NaCl rats. In addition, plasma interleukin-6 (IL-6) levels in the SNx + NaCl rats were significantly increased compared to those in the SNx rats. These findings indicated that NaCl-loaded SNx rats developed LVH and hypertension, which were accompanied with increased plasma levels of PTH, creatinine, inorganic phosphorus, ADMA, and IL-6. Thus, these results suggest that inflammation as well as endothelial dysfunction would be correlated with LVH as non-traditional risk factors at the early stage in the present renal failure model.</description><identifier>ISSN: 0388-6107</identifier><identifier>EISSN: 1880-313X</identifier><identifier>DOI: 10.2220/biomedres.32.83</identifier><identifier>PMID: 21551943</identifier><language>eng</language><publisher>Japan: Biomedical Research Press</publisher><subject>Animals ; Arginine - analogs & derivatives ; Arginine - analysis ; Creatinine - analysis ; Disease Models, Animal ; Fibrosis ; Hypertension - complications ; Hypertrophy, Left Ventricular - blood ; Hypertrophy, Left Ventricular - complications ; Hypertrophy, Left Ventricular - physiopathology ; Inflammation - complications ; Interleukin-6 - biosynthesis ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - physiopathology ; Male ; Nephrectomy - adverse effects ; Parathyroid Hormone - biosynthesis ; Phosphates - analysis ; Rats ; Rats, Wistar ; Risk Factors ; Sclerosis ; Sodium Chloride - adverse effects</subject><ispartof>Biomedical Research, 2011, Vol.32(2), pp.83-90</ispartof><rights>2011 Biomedical Research Press</rights><rights>Copyright Japan Science and Technology Agency 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-2de6da4beb5c672867591aae4ef7d632e2ba1a165d122c41cd242e24d8c879ef3</citedby><cites>FETCH-LOGICAL-c516t-2de6da4beb5c672867591aae4ef7d632e2ba1a165d122c41cd242e24d8c879ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21551943$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moriguchi, Yoshiyuki</creatorcontrib><creatorcontrib>Yogo, Kenji</creatorcontrib><creatorcontrib>Aizawa, Ken</creatorcontrib><creatorcontrib>Serizawa, Ken-ichi</creatorcontrib><creatorcontrib>Tashiro, Yoshihito</creatorcontrib><creatorcontrib>Yorozu, Keigo</creatorcontrib><creatorcontrib>Ishizuka, Nobuhiko</creatorcontrib><creatorcontrib>Iwabuchi, Sadahiro</creatorcontrib><creatorcontrib>Kitamura, Hidemitsu</creatorcontrib><creatorcontrib>Nishimura, Takashi</creatorcontrib><title>Left ventricular hypertrophy is associated with inflammation in sodium loaded subtotal nephrectomized rats</title><title>Biomedical Research</title><addtitle>Biomed. Res.</addtitle><description>The pathological influences of inflammation on left ventricular hypertrophy (LVH) were studied in subtotal nephrectomized (SNx) rats after 0.3% NaCl loading for 5 weeks. We found that mild hypertension, increased plasma levels of creatinine, inorganic phosphate, asymmetric dimethylarginine (ADMA), and parathyroid hormone (PTH) were observed in the present SNx rats without LVH. In the present study, the NaCl-loaded SNx (SNx + NaCl) rats were characterized by significant LVH and hypertension with aggravated values of all the parameters. We further confirmed that glomerular sclerosis, tubulointerstitial fibrosis, and inflammatory cell infiltration into the tubulointerstitial area, observed in the SNx rats, were more severely caused in the SNx + NaCl rats. In addition, plasma interleukin-6 (IL-6) levels in the SNx + NaCl rats were significantly increased compared to those in the SNx rats. These findings indicated that NaCl-loaded SNx rats developed LVH and hypertension, which were accompanied with increased plasma levels of PTH, creatinine, inorganic phosphorus, ADMA, and IL-6. Thus, these results suggest that inflammation as well as endothelial dysfunction would be correlated with LVH as non-traditional risk factors at the early stage in the present renal failure model.</description><subject>Animals</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - analysis</subject><subject>Creatinine - analysis</subject><subject>Disease Models, Animal</subject><subject>Fibrosis</subject><subject>Hypertension - complications</subject><subject>Hypertrophy, Left Ventricular - blood</subject><subject>Hypertrophy, Left Ventricular - complications</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Inflammation - complications</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Male</subject><subject>Nephrectomy - adverse effects</subject><subject>Parathyroid Hormone - biosynthesis</subject><subject>Phosphates - analysis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Risk Factors</subject><subject>Sclerosis</subject><subject>Sodium Chloride - adverse effects</subject><issn>0388-6107</issn><issn>1880-313X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1r3DAQhkVJabZpz70VQQ45eWNJtiwfQ5J-wEIvLfQmxtI41mJbjiS3bH99FTZZaC8zzDvPvAwzhHxg5ZZzXl53zk9oA8at4FslXpENU6osBBM_z8imFEoVkpXNOXkb477MNVPiDTnnrK5ZW4kN2e-wT_QXzik4s44Q6HBYMKTgl-FAXaQQozcOElr626WBurkfYZogOT_ngkZv3TrR0YPNSFy75BOMdMZlCGiSn9yfrAdI8R153cMY8f1zviA_Pt1_v_1S7L59_np7sytMzWQquEVpoeqwq41suJJN3TIArLBvrBQceQcMmKwt49xUzFheZbGyyqimxV5ckKuj7xL844ox6clFg-MIM_o1aiVr2dYt55m8_I_c-zXMeTnNKtk0spJMZOr6SJngYwzY6yW4CcJBs1I_fUGfvqAF1-pp4uOz79rlxol_OXsG7o7APiZ4wBMAITkz4r-G_BiUOLXNAEHjLP4CkWChQA</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Moriguchi, Yoshiyuki</creator><creator>Yogo, Kenji</creator><creator>Aizawa, Ken</creator><creator>Serizawa, Ken-ichi</creator><creator>Tashiro, Yoshihito</creator><creator>Yorozu, Keigo</creator><creator>Ishizuka, Nobuhiko</creator><creator>Iwabuchi, Sadahiro</creator><creator>Kitamura, Hidemitsu</creator><creator>Nishimura, Takashi</creator><general>Biomedical Research Press</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Left ventricular hypertrophy is associated with inflammation in sodium loaded subtotal nephrectomized rats</title><author>Moriguchi, Yoshiyuki ; Yogo, Kenji ; Aizawa, Ken ; Serizawa, Ken-ichi ; Tashiro, Yoshihito ; Yorozu, Keigo ; Ishizuka, Nobuhiko ; Iwabuchi, Sadahiro ; Kitamura, Hidemitsu ; Nishimura, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-2de6da4beb5c672867591aae4ef7d632e2ba1a165d122c41cd242e24d8c879ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - analysis</topic><topic>Creatinine - analysis</topic><topic>Disease Models, Animal</topic><topic>Fibrosis</topic><topic>Hypertension - complications</topic><topic>Hypertrophy, Left Ventricular - blood</topic><topic>Hypertrophy, Left Ventricular - complications</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Inflammation - complications</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Male</topic><topic>Nephrectomy - adverse effects</topic><topic>Parathyroid Hormone - biosynthesis</topic><topic>Phosphates - analysis</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Risk Factors</topic><topic>Sclerosis</topic><topic>Sodium Chloride - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moriguchi, Yoshiyuki</creatorcontrib><creatorcontrib>Yogo, Kenji</creatorcontrib><creatorcontrib>Aizawa, Ken</creatorcontrib><creatorcontrib>Serizawa, Ken-ichi</creatorcontrib><creatorcontrib>Tashiro, Yoshihito</creatorcontrib><creatorcontrib>Yorozu, Keigo</creatorcontrib><creatorcontrib>Ishizuka, Nobuhiko</creatorcontrib><creatorcontrib>Iwabuchi, Sadahiro</creatorcontrib><creatorcontrib>Kitamura, Hidemitsu</creatorcontrib><creatorcontrib>Nishimura, Takashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedical Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moriguchi, Yoshiyuki</au><au>Yogo, Kenji</au><au>Aizawa, Ken</au><au>Serizawa, Ken-ichi</au><au>Tashiro, Yoshihito</au><au>Yorozu, Keigo</au><au>Ishizuka, Nobuhiko</au><au>Iwabuchi, Sadahiro</au><au>Kitamura, Hidemitsu</au><au>Nishimura, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left ventricular hypertrophy is associated with inflammation in sodium loaded subtotal nephrectomized rats</atitle><jtitle>Biomedical Research</jtitle><addtitle>Biomed. Res.</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>32</volume><issue>2</issue><spage>83</spage><epage>90</epage><pages>83-90</pages><issn>0388-6107</issn><eissn>1880-313X</eissn><abstract>The pathological influences of inflammation on left ventricular hypertrophy (LVH) were studied in subtotal nephrectomized (SNx) rats after 0.3% NaCl loading for 5 weeks. We found that mild hypertension, increased plasma levels of creatinine, inorganic phosphate, asymmetric dimethylarginine (ADMA), and parathyroid hormone (PTH) were observed in the present SNx rats without LVH. In the present study, the NaCl-loaded SNx (SNx + NaCl) rats were characterized by significant LVH and hypertension with aggravated values of all the parameters. We further confirmed that glomerular sclerosis, tubulointerstitial fibrosis, and inflammatory cell infiltration into the tubulointerstitial area, observed in the SNx rats, were more severely caused in the SNx + NaCl rats. In addition, plasma interleukin-6 (IL-6) levels in the SNx + NaCl rats were significantly increased compared to those in the SNx rats. These findings indicated that NaCl-loaded SNx rats developed LVH and hypertension, which were accompanied with increased plasma levels of PTH, creatinine, inorganic phosphorus, ADMA, and IL-6. Thus, these results suggest that inflammation as well as endothelial dysfunction would be correlated with LVH as non-traditional risk factors at the early stage in the present renal failure model.</abstract><cop>Japan</cop><pub>Biomedical Research Press</pub><pmid>21551943</pmid><doi>10.2220/biomedres.32.83</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Arginine - analogs & derivatives Arginine - analysis Creatinine - analysis Disease Models, Animal Fibrosis Hypertension - complications Hypertrophy, Left Ventricular - blood Hypertrophy, Left Ventricular - complications Hypertrophy, Left Ventricular - physiopathology Inflammation - complications Interleukin-6 - biosynthesis Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Kidney Failure, Chronic - physiopathology Male Nephrectomy - adverse effects Parathyroid Hormone - biosynthesis Phosphates - analysis Rats Rats, Wistar Risk Factors Sclerosis Sodium Chloride - adverse effects |
| title | Left ventricular hypertrophy is associated with inflammation in sodium loaded subtotal nephrectomized rats |
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