Development of a Bioactive Fiber with Immobilized Synthetic Peptides Designed from the Active Site of a Beetle Defensin
The 9-mer peptides RLYLRIGRR and RLLLRIGRR were immobilized to amino-functionalized cotton fibers by a modification of the SPOT synthesis technique. The antibacterial activities of the peptide-immobilized cotton fibers against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) were inv...
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| Veröffentlicht in: | Biomacromolecules 2011-05, Vol.12 (5), p.1540-1545 |
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| container_issue | 5 |
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| container_title | Biomacromolecules |
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| creator | Nakamura, Makoto Iwasaki, Takashi Tokino, Seiji Asaoka, Ai Yamakawa, Minoru Ishibashi, Jun |
| description | The 9-mer peptides RLYLRIGRR and RLLLRIGRR were immobilized to amino-functionalized cotton fibers by a modification of the SPOT synthesis technique. The antibacterial activities of the peptide-immobilized cotton fibers against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) were investigated. Antibacterial assays revealed that these fibers inhibit the growth of MRSA and the antibacterial activities were maintained after washing and sterilization by autoclaving. The anticancer effect of the peptide-immobilized fiber was also investigated with mouse myeloma cells and human leukemia cells. These results indicate that these fibers have strong growth inhibition activity against bacteria and cancer cells. |
| doi_str_mv | 10.1021/bm1014969 |
| format | Article |
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| source | ACS Publications; MEDLINE |
| subjects | Animals Applied sciences Catalytic Domain Coleoptera - metabolism Exact sciences and technology Fibers and threads Forms of application and semi-finished materials Methicillin-Resistant Staphylococcus aureus - drug effects Peptides - chemical synthesis Peptides - pharmacology Polymer industry, paints, wood Technology of polymers |
| title | Development of a Bioactive Fiber with Immobilized Synthetic Peptides Designed from the Active Site of a Beetle Defensin |
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