Targeting the AKT/GSK3β/Cyclin D1/Cdk4 Survival Signaling Pathway for Eradication of Tumor Radioresistance Acquired by Fractionated Radiotherapy

Purpose Radioresistance is a major cause of treatment failure of radiotherapy (RT) in human cancer. We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3β-dep...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2011-06, Vol.80 (2), p.540-548
Hauptverfasser:	Shimura, Tsutomu, Ph.D, Kakuda, Satoshi, M. Med, Ochiai, Yasushi, B.Sc, Kuwahara, Yoshikazu, Ph.D, Takai, Yoshihiro, M.D., Ph.D, Fukumoto, Manabu, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT AKT inhibitor Animals Apoptosis Biological and medical sciences Cell Proliferation - drug effects Cell Proliferation - radiation effects Cell Survival - drug effects Cell Survival - radiation effects Chlorpropamide - analogs & derivatives Chlorpropamide - pharmacology Cisplatin - pharmacology Cyclin D1 Cyclin D1 - antagonists & inhibitors Cyclin D1 - metabolism Cyclin-Dependent Kinase 4 - antagonists & inhibitors Dose Fractionation Down-Regulation Fractionated radiation Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta HeLa Cells Hematology, Oncology and Palliative Medicine Hep G2 Cells Humans Male Medical sciences Mice Mice, Inbred BALB C Mice, Nude Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Proto-Oncogene Proteins c-akt - antagonists & inhibitors Radiation therapy and radiosensitizing agent Radiation Tolerance - drug effects Radiation Tolerance - physiology Radiation Tolerance - radiation effects Radiation-Sensitizing Agents - pharmacology Radiology Radioresistance Signal Transduction - drug effects Signal Transduction - radiation effects Treatment with physical agents Treatment. General aspects Tumors Xenograft Model Antitumor Assays - methods
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