Bunodosine 391: An Analgesic Acylamino Acid from the Venom of the Sea Anemone Bunodosoma cangicum

A new acylamino acid, bunodosine 391 (BDS 391), was isolated from the venom of the sea anemone Bunodosoma cangicum. The structure was elucidated by spectroscopic analyses (2D NMR, ESIMS/MS) and verified by its synthesis. Intraplantar injection of BDS 391 into the hind paw of a rat induced a potent a...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2011-03, Vol.74 (3), p.378-382
Hauptverfasser:	Zaharenko, André J, Picolo, Gisele, Ferreira, Wilson A, Murakami, Takanori, Kazuma, Kohei, Hashimoto, Masaru, Cury, Yara, de Freitas, José C, Satake, Motoyoshi, Konno, Katsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - chemistry Analgesics - isolation & purification Analgesics - pharmacology Animals Biological and medical sciences Cnidarian Venoms - chemical synthesis Cnidarian Venoms - chemistry Cnidarian Venoms - isolation & purification Cnidarian Venoms - pharmacology Edema - chemically induced Edema - drug therapy General pharmacology Hindlimb - drug effects Male Medical sciences Molecular Structure Naloxone - pharmacology Narcotic Antagonists - pharmacology Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Rats Rats, Wistar Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Sea Anemones - chemistry
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Zusammenfassung:	A new acylamino acid, bunodosine 391 (BDS 391), was isolated from the venom of the sea anemone Bunodosoma cangicum. The structure was elucidated by spectroscopic analyses (2D NMR, ESIMS/MS) and verified by its synthesis. Intraplantar injection of BDS 391 into the hind paw of a rat induced a potent analgesic effect. This effect was not altered by naloxone (an opioid receptor antagonist), but was completely reversed by methysergide (a serotonin receptor antagonist), indicating that the effect is mediated by activation of serotonin receptors.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np100738m