Single-Step Preparation and Deagglomeration of Itraconazole Microflakes by Supercritical Antisolvent Method for Dissolution Enhancement

Itraconazole (ITZ) microflakes were produced by supercritical antisolvent (SAS) method and simultaneously mixed with pharmaceutical excipients in a single step to prevent drug agglomeration. Simultaneous ITZ particle formation and mixing with fast-flo lactose (FFL) was performed in a high-pressure s...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2011-07, Vol.100 (7), p.2952-2965
Hauptverfasser:	Sathigari, Sateesh Kumar, Ober, Courtney A., Sanganwar, Ganesh P., Gupta, Ram B., Babu, R. Jayachandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calorimetry, Differential Scanning Chemistry, Pharmaceutical Chromatography, Supercritical Fluid Crystallization dissolution rate Drug Compounding Excipients - chemistry General pharmacology Itraconazole - chemistry Kinetics Lactose - chemistry Medical sciences Microscopy, Electron, Scanning nanotechnology Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poloxamer - chemistry Rheology Sodium Dodecyl Sulfate - chemistry solid state Solubility Solvents - chemistry Spectroscopy, Fourier Transform Infrared supercritical fluids Surface Properties Surface-Active Agents - chemistry Technology, Pharmaceutical - methods X-Ray Diffraction
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