GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice

ADHD is characterized by hyperactivity and deficits in learning and memory. Now, Eunjoon Kim and colleagues report that a polymorphism in the gene that encodes the adaptor protein GIT1 is linked to ADHD in humans. This polymorphism reduces GIT1 expression, and GIT1-deficient mice show ADHD-like beha...

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Veröffentlicht in:	Nature medicine 2011-05, Vol.17 (5), p.566-572
Hauptverfasser:	Won, Hyejung, Mah, Won, Kim, Eunjin, Kim, Jae-Won, Hahm, Eun-Kyoung, Kim, Myoung-Hwan, Cho, Sukhee, Kim, Jeongjin, Jang, Hyeran, Cho, Soo-Churl, Kim, Boong-Nyun, Shin, Min-Sup, Seo, Jinsoo, Jeong, Jaeseung, Choi, Se-Young, Kim, Daesoo, Kang, Changwon, Kim, Eunjoon
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/727/2000 631/92/436/2388 692/699/476 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - physiology Amphetamine - pharmacology Animal behavior Animals Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - genetics Attention Deficit Disorder with Hyperactivity - physiopathology Attention Deficit Disorder with Hyperactivity - psychology Attention deficit hyperactivity disorder Biomedical and Life Sciences Biomedicine Brain - physiopathology Cancer Research Cell Cycle Proteins - genetics Cell Cycle Proteins - physiology Central Nervous System Stimulants - pharmacology Child Disease Models, Animal Electroencephalography Female G proteins Genetic aspects Genetic Predisposition to Disease GTPase-Activating Proteins - deficiency GTPase-Activating Proteins - genetics Humans Hyperactivity Infectious Diseases Male Memory Disorders - drug therapy Memory Disorders - genetics Memory Disorders - psychology Metabolic Diseases Methylphenidate - pharmacology Mice Mice, Knockout Molecular Medicine Motor Activity - drug effects Motor Activity - genetics Motor Activity - physiology Neuropeptides - metabolism Neurosciences Phenotype Physiological aspects Polymorphism, Single Nucleotide Properties rac GTP-Binding Proteins - metabolism rac1 GTP-Binding Protein Rodents Signal Transduction Synaptic Transmission Toxins
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