P2X(7) receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness

ATP-gated P2X(7) receptors (P2X(7)R) are unusual plasma membrane ion channels that have been extensively studied in immune cells. More recently, P2X(7)R have been described as potential cancer cell biomarkers. However, mechanistic links between P2X(7)R and cancer cell processes are unknown. Here, we...

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Veröffentlicht in:	Oncogene 2011-05, Vol.30 (18), p.2108-2122
Hauptverfasser:	Jelassi, B, Chantôme, A, Alcaraz-Pérez, F, Baroja-Mazo, A, Cayuela, M L, Pelegrin, P, Surprenant, A, Roger, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cathepsins - physiology Cell Line, Tumor Humans Neoplasm Invasiveness Purinergic Agonists - pharmacology Receptors, Purinergic P2X7 - drug effects Small-Conductance Calcium-Activated Potassium Channels - physiology
Online-Zugang:	Volltext
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