Synthesis and Ex Vivo Autoradiographic Evaluation of Ethyl-β-d-galactopyranosyl-(1,4′)-2′-deoxy-2′-[18F]fluoro-β-d-glucopyranoside—A Novel Radioligand for Lactose-Binding Protein: Implications for Early Detection of Pancreatic Carcinomas with PET

Introduction Previous studies demonstrated that the lactose-binding protein (hepatocellular carcinoma–intestine–pancreas and pancreatitis-associated proteins (HIP/PAP)) is upregulated >130 times in peritumoral pancreatic tissue as compared to normal pancreatic tissue. Therefore, we developed a ne...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular imaging and biology 2011-06, Vol.13 (3), p.536-546
Hauptverfasser:	Ying, Yunming, Ghosh, Pradip, Guo, Liwei, Pal, Ashutosh, Mukhapadhyay, Uday, Peng, Zhenghong, Yeh, Hsin Hsien, Bertolini, Susanna, Flores, Leo Garcia, Young, Daniel, Volgin, Andrei, Soghomonyan, Suren, Bornmann, William, Logsdon, Craig, Alauddin, Mian M., Gelovani, Juri G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - metabolism Autoradiography - methods Biomarkers, Tumor - metabolism Chromatography, High Pressure Liquid Disaccharides - chemical synthesis Disaccharides - chemistry Disaccharides - isolation & purification Early Detection of Cancer Glucosides - chemical synthesis Glucosides - chemistry Glucosides - isolation & purification Halogenation Imaging Immunohistochemistry Lactose - metabolism Lectins, C-Type - metabolism Ligands Medicine Medicine & Public Health Mice Neoplasm Proteins - metabolism Pancreatic Neoplasms - diagnostic imaging Pancreatitis-Associated Proteins Positron-Emission Tomography Radiology Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry Research Article
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!