A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population
Variants of the human CYP4A11 , which belongs to the cytochrome P450, family 4, have been reported to be associated with hypertension in general populations. However, data in the Chinese population are limited. This study sought to assess the effect of CYP4A11 on the prevalence of hypertension and b...
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| Veröffentlicht in: | Hypertension research 2011-05, Vol.34 (5), p.645-648 |
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| creator | Zhang, Rong Lu, Jingyi Hu, Cheng Wang, Congrong Yu, Weihui Ma, Xiaojing Bao, Yuqian Xiang, Kunsan Guan, Youfei Jia, Weiping |
| description | Variants of the human
CYP4A11
, which belongs to the cytochrome P450, family 4, have been reported to be associated with hypertension in general populations. However, data in the Chinese population are limited. This study sought to assess the effect of
CYP4A11
on the prevalence of hypertension and blood pressure in a Chinese population. Three tagging single nucleotide polymorphisms, rs9332982, rs4660980 and rs3890011, were genotyped in 1734 community-based participants. Individuals with secondary hypertension were excluded. Sex-pooled and sex-specific analysis for genotype–phenotype association were both conducted. We found rs9332982 T allele was nominally associated with higher prevalence of hypertension in women after adjustment for covariates (OR: 1.38, 95%CI: 1.06–1.81,
P
=0.0183). The significance did not retain after Bonferroni correction. In blood pressure analysis restricted to normotensive individuals, rs4660980 was associated with both systolic (
β
=−3.17,
P
=0.0011) and diastolic blood pressure (
β
=−1.75,
P
=0.0010) in men. A common variant on
CYP4A11
was associated with blood pressure in a Chinese population. Future studies are needed to confirm our findings. |
| doi_str_mv | 10.1038/hr.2011.8 |
| format | Article |
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CYP4A11
, which belongs to the cytochrome P450, family 4, have been reported to be associated with hypertension in general populations. However, data in the Chinese population are limited. This study sought to assess the effect of
CYP4A11
on the prevalence of hypertension and blood pressure in a Chinese population. Three tagging single nucleotide polymorphisms, rs9332982, rs4660980 and rs3890011, were genotyped in 1734 community-based participants. Individuals with secondary hypertension were excluded. Sex-pooled and sex-specific analysis for genotype–phenotype association were both conducted. We found rs9332982 T allele was nominally associated with higher prevalence of hypertension in women after adjustment for covariates (OR: 1.38, 95%CI: 1.06–1.81,
P
=0.0183). The significance did not retain after Bonferroni correction. In blood pressure analysis restricted to normotensive individuals, rs4660980 was associated with both systolic (
β
=−3.17,
P
=0.0011) and diastolic blood pressure (
β
=−1.75,
P
=0.0010) in men. A common variant on
CYP4A11
was associated with blood pressure in a Chinese population. Future studies are needed to confirm our findings.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/hr.2011.8</identifier><identifier>PMID: 21326303</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/457/649 ; 692/699/75/243 ; Aged ; Asian Continental Ancestry Group - genetics ; Asian Continental Ancestry Group - statistics & numerical data ; Blood Pressure - genetics ; China - epidemiology ; Cytochrome P-450 CYP4A ; Cytochrome P-450 Enzyme System - genetics ; Female ; Genetic Association Studies ; Geriatrics/Gerontology ; Health Promotion and Disease Prevention ; Humans ; Hypertension - epidemiology ; Hypertension - genetics ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Obstetrics/Perinatology/Midwifery ; original-article ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Prevalence ; Public Health ; Sex Factors</subject><ispartof>Hypertension research, 2011-05, Vol.34 (5), p.645-648</ispartof><rights>The Japanese Society of Hypertension 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-76043bfcf40293618cfdc39ebdeeaa6c0954039fb3c671a3b138f0dfb2097dd03</citedby><cites>FETCH-LOGICAL-c407t-76043bfcf40293618cfdc39ebdeeaa6c0954039fb3c671a3b138f0dfb2097dd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21326303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Rong</creatorcontrib><creatorcontrib>Lu, Jingyi</creatorcontrib><creatorcontrib>Hu, Cheng</creatorcontrib><creatorcontrib>Wang, Congrong</creatorcontrib><creatorcontrib>Yu, Weihui</creatorcontrib><creatorcontrib>Ma, Xiaojing</creatorcontrib><creatorcontrib>Bao, Yuqian</creatorcontrib><creatorcontrib>Xiang, Kunsan</creatorcontrib><creatorcontrib>Guan, Youfei</creatorcontrib><creatorcontrib>Jia, Weiping</creatorcontrib><title>A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><addtitle>Hypertens Res</addtitle><description>Variants of the human
CYP4A11
, which belongs to the cytochrome P450, family 4, have been reported to be associated with hypertension in general populations. However, data in the Chinese population are limited. This study sought to assess the effect of
CYP4A11
on the prevalence of hypertension and blood pressure in a Chinese population. Three tagging single nucleotide polymorphisms, rs9332982, rs4660980 and rs3890011, were genotyped in 1734 community-based participants. Individuals with secondary hypertension were excluded. Sex-pooled and sex-specific analysis for genotype–phenotype association were both conducted. We found rs9332982 T allele was nominally associated with higher prevalence of hypertension in women after adjustment for covariates (OR: 1.38, 95%CI: 1.06–1.81,
P
=0.0183). The significance did not retain after Bonferroni correction. In blood pressure analysis restricted to normotensive individuals, rs4660980 was associated with both systolic (
β
=−3.17,
P
=0.0011) and diastolic blood pressure (
β
=−1.75,
P
=0.0010) in men. A common variant on
CYP4A11
was associated with blood pressure in a Chinese population. Future studies are needed to confirm our findings.</description><subject>631/208/457/649</subject><subject>692/699/75/243</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Asian Continental Ancestry Group - statistics & numerical data</subject><subject>Blood Pressure - genetics</subject><subject>China - epidemiology</subject><subject>Cytochrome P-450 CYP4A</subject><subject>Cytochrome P-450 Enzyme System - genetics</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Geriatrics/Gerontology</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - genetics</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>original-article</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prevalence</subject><subject>Public Health</subject><subject>Sex Factors</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLxDAURoMozvhY-AckO1HoeG_TyaTLYfAFA7rQhW5CmiY2Q9vUpEX893YYdeXqLu7hwHcIOUOYITBxXYVZCogzsUemyDKRZClm-2QKOfIk54xPyFGMG4BUzHM8JJMUWcoZsCl5W1Ltm8a3tPP1V-NDV7nYUG_p6vUpWyJSF6mK0WunelPST9dXtKi9L2kXTIxDMNS1VNFV5VoTzajphlr1zrcn5MCqOprTn3tMXm5vnlf3yfrx7mG1XCc6g0WfLDhkrLDaZpDmjKPQttQsN0VpjFJcQz7PgOW2YJovULECmbBQ2iKFfFGWwI7Jxc7bBf8xmNjLxkVt6lq1xg9RCj5HwQHFSF7uSB18jMFY2QXXqPAlEeS2pKyC3JaUW_b8xzoUjSn_yN90I3C1A-L4at9NkBs_hHZc-o_tGz3gfEw</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Zhang, Rong</creator><creator>Lu, Jingyi</creator><creator>Hu, Cheng</creator><creator>Wang, Congrong</creator><creator>Yu, Weihui</creator><creator>Ma, Xiaojing</creator><creator>Bao, Yuqian</creator><creator>Xiang, Kunsan</creator><creator>Guan, Youfei</creator><creator>Jia, Weiping</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population</title><author>Zhang, Rong ; Lu, Jingyi ; Hu, Cheng ; Wang, Congrong ; Yu, Weihui ; Ma, Xiaojing ; Bao, Yuqian ; Xiang, Kunsan ; Guan, Youfei ; Jia, Weiping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-76043bfcf40293618cfdc39ebdeeaa6c0954039fb3c671a3b138f0dfb2097dd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>631/208/457/649</topic><topic>692/699/75/243</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Asian Continental Ancestry Group - statistics & numerical data</topic><topic>Blood Pressure - genetics</topic><topic>China - epidemiology</topic><topic>Cytochrome P-450 CYP4A</topic><topic>Cytochrome P-450 Enzyme System - genetics</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Geriatrics/Gerontology</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Hypertension - epidemiology</topic><topic>Hypertension - genetics</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>original-article</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prevalence</topic><topic>Public Health</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Rong</creatorcontrib><creatorcontrib>Lu, Jingyi</creatorcontrib><creatorcontrib>Hu, Cheng</creatorcontrib><creatorcontrib>Wang, Congrong</creatorcontrib><creatorcontrib>Yu, Weihui</creatorcontrib><creatorcontrib>Ma, Xiaojing</creatorcontrib><creatorcontrib>Bao, Yuqian</creatorcontrib><creatorcontrib>Xiang, Kunsan</creatorcontrib><creatorcontrib>Guan, Youfei</creatorcontrib><creatorcontrib>Jia, Weiping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Rong</au><au>Lu, Jingyi</au><au>Hu, Cheng</au><au>Wang, Congrong</au><au>Yu, Weihui</au><au>Ma, Xiaojing</au><au>Bao, Yuqian</au><au>Xiang, Kunsan</au><au>Guan, Youfei</au><au>Jia, Weiping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population</atitle><jtitle>Hypertension research</jtitle><stitle>Hypertens Res</stitle><addtitle>Hypertens Res</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>34</volume><issue>5</issue><spage>645</spage><epage>648</epage><pages>645-648</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>Variants of the human
CYP4A11
, which belongs to the cytochrome P450, family 4, have been reported to be associated with hypertension in general populations. However, data in the Chinese population are limited. This study sought to assess the effect of
CYP4A11
on the prevalence of hypertension and blood pressure in a Chinese population. Three tagging single nucleotide polymorphisms, rs9332982, rs4660980 and rs3890011, were genotyped in 1734 community-based participants. Individuals with secondary hypertension were excluded. Sex-pooled and sex-specific analysis for genotype–phenotype association were both conducted. We found rs9332982 T allele was nominally associated with higher prevalence of hypertension in women after adjustment for covariates (OR: 1.38, 95%CI: 1.06–1.81,
P
=0.0183). The significance did not retain after Bonferroni correction. In blood pressure analysis restricted to normotensive individuals, rs4660980 was associated with both systolic (
β
=−3.17,
P
=0.0011) and diastolic blood pressure (
β
=−1.75,
P
=0.0010) in men. A common variant on
CYP4A11
was associated with blood pressure in a Chinese population. Future studies are needed to confirm our findings.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21326303</pmid><doi>10.1038/hr.2011.8</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/208/457/649 692/699/75/243 Aged Asian Continental Ancestry Group - genetics Asian Continental Ancestry Group - statistics & numerical data Blood Pressure - genetics China - epidemiology Cytochrome P-450 CYP4A Cytochrome P-450 Enzyme System - genetics Female Genetic Association Studies Geriatrics/Gerontology Health Promotion and Disease Prevention Humans Hypertension - epidemiology Hypertension - genetics Internal Medicine Male Medicine Medicine & Public Health Middle Aged Obstetrics/Perinatology/Midwifery original-article Polymorphism, Genetic Polymorphism, Single Nucleotide Prevalence Public Health Sex Factors |
| title | A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population |
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