A Palladium-Catalyzed Aminoalkynylation Strategy towards Bicyclic Heterocycles: Synthesis of (±)-Trachelanthamidine

Sweet cyclizations: The synthesis of pyrrolizidines and indolizidines has been achieved. Olefins were subjected to an intramolecular palladium‐catalyzed aminoalkynylation with the hypervalent iodine reagent TIPS‐EBX. After removal of the protecting group, a two‐step cyclization sequence and subseque...

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Veröffentlicht in:	Angewandte Chemie International Edition 2011-05, Vol.50 (20), p.4680-4683
Hauptverfasser:	Nicolai, Stefano, Piemontesi, Cyril, Waser, Jérôme
Format:	Artikel
Sprache:	eng
Schlagworte:	alkaloids Alkynes - chemistry alkynylation Amides - chemistry amination Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis Bridged Bicyclo Compounds, Heterocyclic - chemistry Catalysis heterocyclic compounds hypervalent iodine Molecular Structure Organometallic Compounds - chemistry Palladium Palladium - chemistry Pyrrolizidine Alkaloids - chemical synthesis Pyrrolizidine Alkaloids - chemistry Stereoisomerism
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