Aldosterone/NaCl-induced renal and cardiac fibrosis is modulated by TGF-β responsiveness of T cells

We examined the contribution of transforming growth factor (TGF)-β-T-cell signaling to aldosterone (aldo)/salt-induced fibrosis in the kidneys and the hearts of FVB/N wild-type (WT) or transgenic (Tg) mice expressing a dominant-negative TGF-β type II receptor in T cells (hCD2-ΔkTβRII). Animals recei...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hypertension research 2011-05, Vol.34 (5), p.623-629
Hauptverfasser:	Schreier, Barbara, Rabe, Sindy, Schneider, Bettina, Ruhs, Stefanie, Grossmann, Claudia, Hauptmann, Steffen, Blessing, Manfred, Neumann, Joachim, Gekle, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127/1219 631/250/1619/554 692/699/1585 692/699/75 Aldosterone - pharmacology Animals Blood Pressure - drug effects Collagen - biosynthesis Extracellular Matrix - drug effects Extracellular Matrix - metabolism Fibronectins - biosynthesis Fibrosis Geriatrics/Gerontology Health Promotion and Disease Prevention Internal Medicine Kidney - drug effects Kidney - pathology Medicine Medicine & Public Health Mice Mice, Transgenic Myocardium - pathology Obstetrics/Perinatology/Midwifery Organ Size - drug effects original-article Plasminogen Activator Inhibitor 1 - biosynthesis Proteinuria - chemically induced Public Health Sodium Chloride, Dietary - pharmacology T-Lymphocytes - drug effects T-Lymphocytes - pathology Transforming Growth Factor beta - genetics Transforming Growth Factor beta - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!