Perhaloalkylation of Metal Enolates-Unconventional and Versatile

Perhaloalkylation of Metal Enolates-Unconventional and Versatile

Radically unconventional: Natural products with di‐ and trichloromethyl groups and trifluoromethylated pharmaceuticals and agrochemicials are interesting compounds, often with intriguing properties. These types of compounds can be prepared by the direct perhaloalkylation of carbonyl compounds in whi...

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Veröffentlicht in:Angewandte Chemie International Edition 2011-05, Vol.50 (20), p.4542-4544
Hauptverfasser: Amatov, Tynchtyk, Jahn, Ullrich
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
electron transfer
enols
Ketones - chemical synthesis
Ketones - chemistry
Molecular Conformation
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
perhaloalkylation
radical reactions
Stereoisomerism
valence tautomerism
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Beschreibung
Zusammenfassung:Radically unconventional: Natural products with di‐ and trichloromethyl groups and trifluoromethylated pharmaceuticals and agrochemicials are interesting compounds, often with intriguing properties. These types of compounds can be prepared by the direct perhaloalkylation of carbonyl compounds in which enolate reactivity and radical reactivity are merged (see scheme; Bn=benzyl).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201007672