Regulation of androgen receptor expression through angiotensin II type 1 receptor in prostate cancer cells

BACKGROUND Although the local renin‐angiotensin system (RAS) of the prostate gland is related to cell proliferation and angiogenesis, the detailed mechanism remains unclear. We examined the effects of the angiotensin II type 1 receptor (AT1R) on androgen receptor (AR) expression in prostate cancer c...

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Veröffentlicht in:	The Prostate 2011-06, Vol.71 (9), p.964-975
Hauptverfasser:	Hoshino, Koji, Ishiguro, Hitoshi, Teranishi, Jun-ichi, Yoshida, Shin-ichiro, Umemura, Satoshi, Kubota, Yoshinobu, Uemura, Hiroji
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen receptor Angiotensin II - metabolism angiotensin II receptor Animals Blotting, Western Cell Line, Tumor Cell Proliferation Gene Expression Regulation, Neoplastic Immunohistochemistry Male Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Knockout NF-kappa B - metabolism prostate cancer Prostate-Specific Antigen - metabolism Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Proto-Oncogene Proteins c-myc - metabolism Receptor, Angiotensin, Type 1 - metabolism Receptors, Androgen - biosynthesis Receptors, Androgen - genetics Reverse Transcriptase Polymerase Chain Reaction RNA - chemistry RNA - genetics RNA, Small Interfering - pharmacology siRNA
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