Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN

The Per-Arnt-Sim (PAS) domain serine/threonine kinase PASKIN, or PAS kinase, links energy flux and protein synthesis in yeast, regulates glycogen synthesis and protein translation in mammals, and might be involved in insulin regulation in the pancreas. According to the current model, binding of a pu...

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Veröffentlicht in:	The FEBS journal 2011-05, Vol.278 (10), p.1757-1768
Hauptverfasser:	Schläfli, Philipp, Tröger, Juliane, Eckhardt, Katrin, Borter, Emanuela, Spielmann, Patrick, Wenger, Roland H
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Amino Acid Sequence Catalysis Catalytic Domain energy flow glycogen insulin Insulin - metabolism Kinases ligands Lipids mammals metabolism pancreas Peptides phosphates Phosphatidylinositol Phosphates - pharmacology phosphatidylinositols phospholipid Phosphorylation protein synthesis protein translation protein-serine-threonine kinases Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Proteins ribosomal protein S6 Ribosomal Protein S6 - metabolism sensory kinase serine Substrate Specificity Substrates threonine yeasts
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